Compounds

Type:
---

AlogP:
4.89

Polar Surface Area:
62.46

HBA:
4

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.75

DETAILS

ALA5209497

Name:
(R)-8-amino-5-(3-fluoro-4-((2-methylpyrrolidin-1-yl)methyl)phenyl)-2-(4-metShow More⌵

Mol. Formula:
C27H35FN4O

M.W.:
450.60

Type:
---

AlogP:
5.03

Polar Surface Area:
62.46

HBA:
4

HBD:
1

#RO5 Violations:
1

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.71

DETAILS

ALA5207070

Name:
8-amino-2-cyclohexyl-5-(1-(oxetan-3-yl)-1H-pyrazol-4-yl)-3,4-dihydro-2,7-naShow More⌵

Mol. Formula:
C20H25N5O2

M.W.:
367.45

Type:
---

AlogP:
2.43

Polar Surface Area:
86.27

HBA:
6

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.90

DETAILS

ALA5205791

Name:
2-amino-5-(3-fluoro-4-(((R)-2-methylpyrrolidin-1-yl)methyl)phenyl)-N-((1r,4Show More⌵

Mol. Formula:
C25H33FN4O2

M.W.:
440.56

Type:
---

AlogP:
3.88

Polar Surface Area:
91.48

HBA:
5

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.66

DETAILS

ALA5205781

Name:
Rac-8-amino-2-cyclohexyl-5-(1-(piperidin-3-yl)-1H-pyrazol-4-yl)-3,4-dihydroShow More⌵

Mol. Formula:
C22H30N6O

M.W.:
394.52

Type:
---

AlogP:
2.78

Polar Surface Area:
89.07

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.84

DETAILS

ALA5200241

Name:
8-amino-2-cyclohexyl-5-(1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-3,4-dihShow More⌵

Mol. Formula:
C23H32N6O

M.W.:
408.55

Type:
---

AlogP:
3.13

Polar Surface Area:
80.28

HBA:
6

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.84

DETAILS

ALA5197985

Name:
8-amino-2-cyclobutyl-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-3,4-dihydro-2,7Show More⌵

Mol. Formula:
C20H26N6O

M.W.:
366.47

Type:
---

AlogP:
2.00

Polar Surface Area:
89.07

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.87

DETAILS

ALA5197788

Name:
8-amino-2-cyclohexyl-5-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydro-2,7-naphthyriShow More⌵

Mol. Formula:
C18H23N5O

M.W.:
325.42

Type:
---

AlogP:
2.40

Polar Surface Area:
77.04

HBA:
5

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
2

Passes Ro3:
N

QED Weighted:
0.92

DETAILS

ALA5197416

Name:
8-amino-2-cyclohexyl-5-(1-methyl-1H-pyrrol-3-yl)-3,4-dihydro-2,7-naphthyridShow More⌵

Mol. Formula:
C19H24N4O

M.W.:
324.43

Type:
---

AlogP:
3.00

Polar Surface Area:
64.15

HBA:
4

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
2

Passes Ro3:
N

QED Weighted:
0.92

DETAILS

ALA5196975

Name:
8-amino-2-cyclohexyl-5-(1-methyl-1H-pyrazol-3-yl)-3,4-dihydro-2,7-naphthyriShow More⌵

Mol. Formula:
C18H23N5O

M.W.:
325.42

Type:
---

AlogP:
2.40

Polar Surface Area:
77.04

HBA:
5

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
2

Passes Ro3:
N

QED Weighted:
0.92

DETAILS

ALA5196379

Name:
Rac-8-amino-2-(4-hydroxy-4-methylcyclohexyl)-5-(1-(piperidin-4-yl)-1H-pyrazShow More⌵

Mol. Formula:
C23H32N6O2

M.W.:
424.55

Type:
---

AlogP:
2.14

Polar Surface Area:
109.30

HBA:
7

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.70

DETAILS

ALA5195463

Name:
(R)-8-amino-2-(4-hydroxycyclohexyl)-5-(4-((2-methylpyrrolidin-1-yl)methyl)pShow More⌵

Mol. Formula:
C26H34N4O2

M.W.:
434.58

Type:
---

AlogP:
3.62

Polar Surface Area:
82.69

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.77

DETAILS

ALA5195236

Name:
Rac-8-amino-2-cyclohexyl-5-(1-(piperidin-3-ylmethyl)-1H-pyrazol-4-yl)-3,4-dShow More⌵

Mol. Formula:
C23H32N6O

M.W.:
408.55

Type:
---

AlogP:
2.86

Polar Surface Area:
89.07

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.81

DETAILS

ALA5194265

Name:
8-amino-2-isopropyl-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-3,4-dihydro-2,7-Show More⌵

Mol. Formula:
C19H26N6O

M.W.:
354.46

Type:
---

AlogP:
1.86

Polar Surface Area:
89.07

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.88

DETAILS

ALA5191364

Name:
(R)-8-amino-5-(3-fluoro-4-((2-methylpyrrolidin-1-yl)methyl)phenyl)-2-(4-hydShow More⌵

Mol. Formula:
C26H33FN4O2

M.W.:
452.57

Type:
---

AlogP:
3.76

Polar Surface Area:
82.69

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.74

DETAILS

ALA5190190

Name:
8-amino-2-methyl-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-3,4-dihydro-2,7-napShow More⌵

Mol. Formula:
C17H22N6O

M.W.:
326.40

Type:
---

AlogP:
1.08

Polar Surface Area:
89.07

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
2

Passes Ro3:
N

QED Weighted:
0.86

DETAILS

ALA5190065

Name:
(R)-8-amino-2-(4-hydroxy-4-methylcyclohexyl)-5-(4-((2-methylpyrrolidin-1-ylShow More⌵

Mol. Formula:
C27H36N4O2

M.W.:
448.61

Type:
---

AlogP:
4.01

Polar Surface Area:
82.69

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.74

DETAILS

ALA5189688

Name:
8-amino-2-cyclohexyl-5-(1-cyclopentyl-1H-pyrazol-4-yl)-3,4-dihydro-2,7-naphShow More⌵

Mol. Formula:
C22H29N5O

M.W.:
379.51

Type:
---

AlogP:
3.97

Polar Surface Area:
77.04

HBA:
5

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.88

DETAILS

ALA5189461

Name:
8-amino-2-cyclohexyl-5-(1-(piperidin-4-ylmethyl)-1H-pyrazol-4-yl)-3,4-dihydShow More⌵

Mol. Formula:
C23H32N6O

M.W.:
408.55

Type:
---

AlogP:
2.86

Polar Surface Area:
89.07

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.81

DETAILS

ALA5189032

Name:
8-amino-2-cyclohexyl-5-p-tolyl-3,4-dihydro-2,7-naphthyridin-1(2H)-one

Mol. Formula:
C21H25N3O

M.W.:
335.45