Compounds

ALA5267045

Name:
5-methyl-2-(3-((2-(methylamino)ethylamino)methyl)phenyl)-N4-phenyl-N6-(tetrShow More⌵

Mol. Formula:
C26H34N6O

M.W.:
446.60

Type:
---

AlogP:
4.10

Polar Surface Area:
83.13

HBA:
7

HBD:
4

#RO5 Violations:
---

#Rotatable Bonds:
10

Passes Ro3:
N

QED Weighted:
0.35

DETAILS

ALA5266897

Name:
(S)-2-amino-N-(3-(5-methyl-4-(pyridin-4-yl)-6-(tetrahydro-2H-pyran-4-ylaminShow More⌵

Mol. Formula:
C25H30N6O2

M.W.:
446.56

Type:
---

AlogP:
3.07

Polar Surface Area:
115.05

HBA:
7

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.51

DETAILS

ALA5266735

Name:
(S)-2-amino-N-(3-(4-(3,5-dimethylisoxazol-4-yl)-5-methyl-6-(tetrahydro-2H-pShow More⌵

Mol. Formula:
C25H32N6O3

M.W.:
464.57

Type:
---

AlogP:
3.28

Polar Surface Area:
128.19

HBA:
8

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.49

DETAILS

ALA5266710

Name:
N1-(3-(4-(4-methoxyphenyl)-5-methyl-6-(tetrahydro-2H-pyran-4-ylamino)pyrimiShow More⌵

Mol. Formula:
C27H35N5O2

M.W.:
461.61

Type:
---

AlogP:
4.03

Polar Surface Area:
80.33

HBA:
7

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
10

Passes Ro3:
N

QED Weighted:
0.39

DETAILS

ALA5266548

Name:
N1-(3-(4-(1H-indol-4-yl)-5-methyl-6-(tetrahydro-2H-pyran-4-ylamino)pyrimidiShow More⌵

Mol. Formula:
C28H34N6O

M.W.:
470.62

Type:
---

AlogP:
4.50

Polar Surface Area:
86.89

HBA:
6

HBD:
4

#RO5 Violations:
---

#Rotatable Bonds:
9

Passes Ro3:
N

QED Weighted:
0.27

DETAILS

ALA5280681

Name:
(S)-2-amino-N-(3-(5-methyl-4-phenyl-6-(tetrahydro-2H-pyran-4-ylamino)pyrimiShow More⌵

Mol. Formula:
C26H31N5O2

M.W.:
445.57

Type:
---

AlogP:
3.67

Polar Surface Area:
102.16

HBA:
6

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.51

DETAILS

ALA5279447

Name:
N1-(3-(4-(3,5-Dimethylisoxazol-4-yl)-5-methyl-6-(4-methylpiperazin-1-yl)pyrShow More⌵

Mol. Formula:
C25H35N7O

M.W.:
449.60

Type:
---

AlogP:
2.78

Polar Surface Area:
82.35

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
8

Passes Ro3:
N

QED Weighted:
0.51

DETAILS

ALA5279188

Name:
N1-(3-(4-chloro-5-methyl-6-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-2-yl)beShow More⌵

Mol. Formula:
C20H28ClN5O

M.W.:
389.93

Type:
---

AlogP:
3.01

Polar Surface Area:
71.10

HBA:
6

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
8

Passes Ro3:
N

QED Weighted:
0.48

DETAILS

ALA5279093

Name:
N1-methyl-N2-(3-(5-methyl-4-(4-(methylsulfonyl)phenyl)-6-(tetrahydro-2H-pyrShow More⌵

Mol. Formula:
C27H35N5O3S

M.W.:
509.68

Type:
---

AlogP:
3.42

Polar Surface Area:
105.24

HBA:
8

HBD:
3

#RO5 Violations:
1

#Rotatable Bonds:
10

Passes Ro3:
N

QED Weighted:
0.36

DETAILS

ALA5278488

Name:
N1-(3-(4-(7-methoxy-1H-indol-2-yl)-5-methyl-6-(tetrahydro-2H-pyran-4-ylaminShow More⌵

Mol. Formula:
C29H36N6O2

M.W.:
500.65

Type:
---

AlogP:
4.51

Polar Surface Area:
96.12

HBA:
7

HBD:
4

#RO5 Violations:
1

#Rotatable Bonds:
10

Passes Ro3:
N

QED Weighted:
0.24

DETAILS

ALA5277762

Name:
N1-(3-(4-(benzyloxy)-5-methyl-6-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-2-Show More⌵

Mol. Formula:
C27H35N5O2

M.W.:
461.61

Type:
---

AlogP:
3.93

Polar Surface Area:
80.33

HBA:
7

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
11

Passes Ro3:
N

QED Weighted:
0.37

DETAILS

ALA5277620

Name:
N1-(3-(4-(isoquinolin-5-yl)-5-methyl-6-(tetrahydro-2H-pyran-4-ylamino)pyrimShow More⌵

Mol. Formula:
C29H34N6O

M.W.:
482.63

Type:
---

AlogP:
4.57

Polar Surface Area:
83.99

HBA:
7

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
9

Passes Ro3:
N

QED Weighted:
0.30

DETAILS

ALA5275579

Name:
(S)-2-amino-3-hydroxy-N-(3-(5-methyl-4-phenyl-6-(tetrahydro-2H-pyran-4-ylamShow More⌵

Mol. Formula:
C26H31N5O3

M.W.:
461.57

Type:
---

AlogP:
2.65

Polar Surface Area:
122.39

HBA:
7

HBD:
4

#RO5 Violations:
---

#Rotatable Bonds:
8

Passes Ro3:
N

QED Weighted:
0.41

DETAILS

ALA5274712

Name:
methyl 2-(2-(2-chloro-5-((R)-2-hydroxy-3-(methylamino)propoxy)phenyl)-6-(3,Show More⌵

Mol. Formula:
C29H37ClN6O5

M.W.:
585.11

Type:
---

AlogP:
4.00

Polar Surface Area:
126.08

HBA:
10

HBD:
2

#RO5 Violations:
1

#Rotatable Bonds:
8

Passes Ro3:
N

QED Weighted:
0.40

DETAILS

ALA5274541

Name:
N1-methyl-N2-(3-(5-methyl-6-(tetrahydro-2H-pyran-4-ylamino)-4,5'-bipyrimidiShow More⌵

Mol. Formula:
C24H31N7O

M.W.:
433.56

Type:
---

AlogP:
2.81

Polar Surface Area:
96.88

HBA:
8

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
9

Passes Ro3:
N

QED Weighted:
0.44

DETAILS

ALA5274219

Name:
N1-methyl-N2-(3-(5-methyl-4-(pyridin-3-yl)-6-(tetrahydro-2H-pyran-4-ylaminoShow More⌵

Mol. Formula:
C25H32N6O

M.W.:
432.57

Type:
---

AlogP:
3.41

Polar Surface Area:
83.99

HBA:
7

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
9

Passes Ro3:
N

QED Weighted:
0.45

DETAILS

ALA5273938

Name:
N1-methyl-N2-(3-(5-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-6-(4-(trifluoroShow More⌵

Mol. Formula:
C27H32F3N5O2

M.W.:
515.58

Type:
---

AlogP:
4.92

Polar Surface Area:
80.33

HBA:
7

HBD:
3

#RO5 Violations:
1

#Rotatable Bonds:
10

Passes Ro3:
N

QED Weighted:
0.33

DETAILS

ALA5291238

Name:
N1-(3-(4-(3,5-dimethylisoxazol-4-yl)-5-methyl-6-morpholinopyrimidin-2-yl)beShow More⌵

Mol. Formula:
C24H32N6O2

M.W.:
436.56

Type:
---

AlogP:
2.87

Polar Surface Area:
88.34

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
8

Passes Ro3:
N

QED Weighted:
0.52

DETAILS

ALA5290686

Name:
N1-methyl-N2-(3-(5-methyl-4-phenoxy-6-(tetrahydro-2H-pyran-4-ylamino)pyrimiShow More⌵

Mol. Formula:
C26H33N5O2

M.W.:
447.58

Type:
---

AlogP:
4.14

Polar Surface Area:
80.33

HBA:
7

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
10

Passes Ro3:
N

QED Weighted:
0.40

DETAILS

ALA5290611

Name:
N1-methyl-N2-(3-(5-methyl-4-phenyl-6-(tetrahydro-2H-pyran-4-ylamino)pyrimidShow More⌵

Mol. Formula:
C26H33N5O

M.W.:
431.58

Type:
---

AlogP:
4.02

Polar Surface Area:
71.10

HBA:
6

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
9

Passes Ro3:
N

QED Weighted:
0.44

DETAILS