Compounds

ALA5271976

Name:
3-(4-(4-methylpiperazin-1-yl)phenyl)-5-phenyl-1H-pyrazolo[4,3-b]pyridine

Mol. Formula:
C23H23N5

M.W.:
369.47

Type:
---

AlogP:
4.04

Polar Surface Area:
48.05

HBA:
4

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.59

DETAILS

ALA5271703

Name:
(R)-N-(4-(3-Aminopyrrolidin-1-yl)-7-fluoro-1-methyl-1H-indazol-5-yl)-2-(2-fShow More⌵

Mol. Formula:
C24H23F2N7O2

M.W.:
479.49

Type:
---

AlogP:
3.11

Polar Surface Area:
111.19

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.45

DETAILS

ALA5271378

Name:
(R)-N-(2-(3-Aminopyrrolidin-1-yl)-5-fluorophenyl)-2-(2-fluoro-6-methoxyphenShow More⌵

Mol. Formula:
C22H21F2N5O2

M.W.:
425.44

Type:
---

AlogP:
3.22

Polar Surface Area:
93.37

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.65

DETAILS

ALA5270339

Name:
N-(4-(4-methylpiperazin-1-yl)phenyl)-7-phenylquinazolin-2-amine

Mol. Formula:
C25H25N5

M.W.:
395.51

Type:
---

AlogP:
4.79

Polar Surface Area:
44.29

HBA:
5

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.54

DETAILS

ALA5269770

Name:
(R)-N-(4-(3-Aminopyrrolidin-1-yl)-1-methyl-1H-indazol-5-yl)-2-(2-fluoro-6-mShow More⌵

Mol. Formula:
C24H24FN7O2

M.W.:
461.50

Type:
---

AlogP:
2.97

Polar Surface Area:
111.19

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.47

DETAILS

ALA5269588

Name:
N-(2-((1R,4R)-2,5-Diazabicyclo[2.2.1]heptan-2-yl)-5-fluorophenyl)-2-(2-fluoShow More⌵

Mol. Formula:
C23H21F2N5O2

M.W.:
437.45

Type:
---

AlogP:
3.23

Polar Surface Area:
79.38

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.64

DETAILS

ALA5268277

Name:
(R)-N-(7-Fluoro-1-methyl-4-(2-methylpiperazin-1-yl)-1H-indazol-5-yl)-2-(2-fShow More⌵

Mol. Formula:
C25H25F2N7O2

M.W.:
493.52

Type:
---

AlogP:
3.37

Polar Surface Area:
97.20

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.44

DETAILS

ALA5267747

Name:
(R)-N-(2-(3-aminopiperidin-1-yl)phenyl)-2-(2-fluoro-6-methoxyphenyl)pyrimidShow More⌵

Mol. Formula:
C23H24FN5O2

M.W.:
421.48

Type:
---

AlogP:
3.47

Polar Surface Area:
93.37

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.66

DETAILS

ALA5281003

Name:
(R)-N-(4-(3-Aminopyrrolidin-1-yl)-1-methyl-1H-benzo[d]imidazol-5-yl)-2-(2-fShow More⌵

Mol. Formula:
C24H24FN7O2

M.W.:
461.50

Type:
---

AlogP:
2.97

Polar Surface Area:
111.19

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.47

DETAILS

ALA5280838

Name:
N-(4-((2S,4S)-2-(Aminomethyl)-4-hydroxypyrrolidin-1-yl)-7-fluoro-1-methyl-1Show More⌵

Mol. Formula:
C25H25F2N7O3

M.W.:
509.52

Type:
---

AlogP:
2.47

Polar Surface Area:
131.42

HBA:
9

HBD:
3

#RO5 Violations:
1

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.36

DETAILS

ALA5279971

Name:
(R)-N-(6-(3-Aminopyrrolidin-1-yl)-1-methyl-1H-indazol-5-yl)-2-(2-fluoro-6-mShow More⌵

Mol. Formula:
C24H24FN7O2

M.W.:
461.50

Type:
---

AlogP:
2.97

Polar Surface Area:
111.19

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.47

DETAILS

ALA5279882

Name:
N-(2-((2S,4S)-4-Amino-2-(hydroxymethyl)pyrrolidin-1-yl)-4-(4-cyano-1-methylShow More⌵

Mol. Formula:
C28H27FN8O3

M.W.:
542.58

Type:
---

AlogP:
2.71

Polar Surface Area:
155.21

HBA:
10

HBD:
3

#RO5 Violations:
1

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.32

DETAILS

ALA5279503

Name:
N-(2-((2S,4S)-4-Amino-2-(hydroxymethyl)pyrrolidin-1-yl)-4-(4-cyano-2-methylShow More⌵

Mol. Formula:
C29H26FN7O3

M.W.:
539.57

Type:
---

AlogP:
3.38

Polar Surface Area:
150.28

HBA:
9

HBD:
3

#RO5 Violations:
1

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.32

DETAILS

ALA5279231

Name:
N-(4-((2R,4S)-4-Amino-2-methylpyrrolidin-1-yl)-7-fluoro-1-methyl-1H-indazolShow More⌵

Mol. Formula:
C25H25F2N7O2

M.W.:
493.52

Type:
---

AlogP:
3.50

Polar Surface Area:
111.19

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.44

DETAILS

ALA5277299

Name:
N-(2-((1S,4S)-2,5-Diazabicyclo[2.2.1]heptan-2-yl)-5-fluoro-4-(2-methylpyridShow More⌵

Mol. Formula:
C29H26F2N6O2

M.W.:
528.56

Type:
---

AlogP:
4.60

Polar Surface Area:
92.27

HBA:
7

HBD:
2

#RO5 Violations:
1

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.38

DETAILS

ALA5277241

Name:
(R)-N-(4-(3-Aminopyrrolidin-1-yl)-2-methylbenzo[d]thiazol-5-yl)-2-(2-fluoroShow More⌵

Mol. Formula:
C24H23FN6O2S

M.W.:
478.55

Type:
---

AlogP:
4.00

Polar Surface Area:
106.26

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.45

DETAILS

ALA5276781

Name:
N-(4-((1S,4S)-2,5-Diazabicyclo[2.2.1]heptan-2-yl)-7-fluoro-1-methyl-1H-indaShow More⌵

Mol. Formula:
C25H23F2N7O2

M.W.:
491.50

Type:
---

AlogP:
3.12

Polar Surface Area:
97.20

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.44

DETAILS

ALA5276026

Name:
N-(4-((2S,3R)-2-(aminomethyl)-3-hydroxypyrrolidin-1-yl)-7-fluoro-1-methyl-1Show More⌵

Mol. Formula:
C25H25F2N7O3

M.W.:
509.52

Type:
---

AlogP:
2.47

Polar Surface Area:
131.42

HBA:
9

HBD:
3

#RO5 Violations:
1

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.36

DETAILS

ALA5274764

Name:
(S)-N-(7-Fluoro-4-(2-(hydroxymethyl)pyrrolidin-1-yl)-1-methyl-1H-indazol-5-Show More⌵

Mol. Formula:
C25H24F2N6O3

M.W.:
494.50

Type:
---

AlogP:
3.53

Polar Surface Area:
105.40

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.42

DETAILS

ALA5274556

Name:
(R)-N-(4-(3-Aminopyrrolidin-1-yl)-7-fluoro-2-methyl-2H-indazol-5-yl)-2-(2-fShow More⌵

Mol. Formula:
C24H23F2N7O2

M.W.:
479.49

Type:
---

AlogP:
3.11

Polar Surface Area:
111.19

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.45

DETAILS