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  1. ALA5272651

    Name:
    2-(3,3-dimethylcyclobutane-1-carboxamido)-N-(4-phenylpyridin-3-yl)isonicotiShow More

    Mol. Formula:
    C24H24N4O2

    M.W.:
    400.48

    Type:
    ---

    AlogP:
    4.77

    Polar Surface Area:
    83.98

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.65

    DETAILS
  2. ALA5272462

    Name:
    N-(5-(2-chlorophenyl)pyridin-3-yl)-2-(3,3-difluorocyclopentane-1-carboxamidShow More

    Mol. Formula:
    C23H19ClF2N4O2

    M.W.:
    456.88

    Type:
    ---

    AlogP:
    5.42

    Polar Surface Area:
    83.98

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    1

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.54

    DETAILS
  3. ALA5272429

    Name:
    methyl (3-(4-nitrobenzylidene)-2-oxoindolin-5-yl)carbamate

    Mol. Formula:
    C17H13N3O5

    M.W.:
    339.31

    Type:
    ---

    AlogP:
    3.27

    Polar Surface Area:
    110.57

    HBA:
    5

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.51

    DETAILS
  4. ALA5272358

    Name:
    2-(cyclopropanecarboxamido)-N-(5-(4-fluorophenyl)pyridin-3-yl)isonicotinamiShow More

    Mol. Formula:
    C21H17FN4O2

    M.W.:
    376.39

    Type:
    ---

    AlogP:
    3.88

    Polar Surface Area:
    83.98

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.71

    DETAILS
  5. ALA5272115

    Name:
    N-(4-(2,2-difluoropropoxy)pyridin-3-yl)-2-isobutyramidoisonicotinamide

    Mol. Formula:
    C18H20F2N4O3

    M.W.:
    378.38

    Type:
    ---

    AlogP:
    3.36

    Polar Surface Area:
    93.21

    HBA:
    5

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.77

    DETAILS
  6. ALA5272041

    Name:
    2-(cyclopropanecarboxamido)-N-(4-(2,2-dimethylmorpholino)pyridin-3-yl)isoniShow More

    Mol. Formula:
    C21H25N5O3

    M.W.:
    395.46

    Type:
    ---

    AlogP:
    2.69

    Polar Surface Area:
    96.45

    HBA:
    6

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.81

    DETAILS
  7. ALA5272013

    Name:
    (R)-2-(cyclopropanecarboxamido)-N-(4-(2-methylmorpholino)pyridin-3-yl)isoniShow More

    Mol. Formula:
    C20H23N5O3

    M.W.:
    381.44

    Type:
    ---

    AlogP:
    2.30

    Polar Surface Area:
    96.45

    HBA:
    6

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.83

    DETAILS
  8. ALA5271833

    Name:
    (2Z)-2-(1,3-benzodioxol-5-ylmethylene)-7-[[benzyl(methyl)amino]methyl]-6-hyShow More

    Mol. Formula:
    C25H21NO5

    M.W.:
    415.45

    Type:
    ---

    AlogP:
    4.37

    Polar Surface Area:
    68.23

    HBA:
    6

    HBD:
    1

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.62

    DETAILS
  9. ALA5271795

    Name:
    1-methyl-3-(pyridin-2-ylmethylene)indolin-2-one

    Mol. Formula:
    C15H12N2O

    M.W.:
    236.27

    Type:
    ---

    AlogP:
    2.60

    Polar Surface Area:
    33.20

    HBA:
    2

    HBD:
    ---

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    1

    Passes Ro3:
    Y

    QED Weighted:
    0.71

    DETAILS
  10. ALA5271697

    Name:
    1-(1)H-2,4,8-triaza-3(4,2)-pyrimidina-1(3,5)-pyrazola-5(1,4)-benzenacyclonoShow More

    Mol. Formula:
    C16H15N7O

    M.W.:
    321.34

    Type:
    ---

    AlogP:
    1.97

    Polar Surface Area:
    107.62

    HBA:
    6

    HBD:
    4

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    ---

    Passes Ro3:
    N

    QED Weighted:
    0.50

    DETAILS
  11. ALA5271607

    Name:
    2-(3,3-difluorocyclopentane-1-carboxamido)-N-(5-(2-fluorophenyl)pyridin-3-yShow More

    Mol. Formula:
    C23H19F3N4O2

    M.W.:
    440.43

    Type:
    ---

    AlogP:
    4.91

    Polar Surface Area:
    83.98

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.59

    DETAILS
  12. ALA5271559

    Name:
    4-((2-chlorophenyl)amino)-6-((6-hydroxypyridin-2-yl)amino)nicotinamide

    Mol. Formula:
    C17H14ClN5O2

    M.W.:
    355.79

    Type:
    ---

    AlogP:
    3.42

    Polar Surface Area:
    113.16

    HBA:
    6

    HBD:
    4

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.56

    DETAILS
  13. ALA5271312

    Name:
    2-(3,3-difluorocyclobutane-1-carboxamido)-N-(5-phenylpyridin-3-yl)isonicotiShow More

    Mol. Formula:
    C22H18F2N4O2

    M.W.:
    408.41

    Type:
    ---

    AlogP:
    4.38

    Polar Surface Area:
    83.98

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.66

    DETAILS
  14. ALA5271237

    Name:
    N-(2-oxo-3-(pyridin-3-ylmethylene)indolin-5-yl)acetamide

    Mol. Formula:
    C16H13N3O2

    M.W.:
    279.30

    Type:
    ---

    AlogP:
    2.53

    Polar Surface Area:
    71.09

    HBA:
    3

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    2

    Passes Ro3:
    N

    QED Weighted:
    0.83

    DETAILS
  15. ALA5271220

    Name:
    1-(1)H-2,4,8-triaza-3(4,2)-pyrimidina-1(3,5)-pyrazola-5(1,3)-benzenacyclonoShow More

    Mol. Formula:
    C16H15N7O

    M.W.:
    321.34

    Type:
    ---

    AlogP:
    1.97

    Polar Surface Area:
    107.62

    HBA:
    6

    HBD:
    4

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    ---

    Passes Ro3:
    N

    QED Weighted:
    0.50

    DETAILS
  16. ALA5271154

    Name:
    N-(5-(2,3-difluorophenyl)pyridin-3-yl)-2-pivalamidoisonicotinamide

    Mol. Formula:
    C22H20F2N4O2

    M.W.:
    410.42

    Type:
    ---

    AlogP:
    4.66

    Polar Surface Area:
    83.98

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.66

    DETAILS
  17. ALA5271077

    Name:
    2-isobutyramido-N-(4-(2,2,2-trifluoroethoxy)pyridin-3-yl)isonicotinamide

    Mol. Formula:
    C17H17F3N4O3

    M.W.:
    382.34

    Type:
    ---

    AlogP:
    3.26

    Polar Surface Area:
    93.21

    HBA:
    5

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.80

    DETAILS
  18. ALA5270462

    Name:
    (3Z)-3-{[5-(2-methoxyacetyl)-1H-pyrazol-4-yl]methylidene}-2,3-dihydro-1H-inShow More

    Mol. Formula:
    C15H13N3O3

    M.W.:
    283.29

    Type:
    ---

    AlogP:
    1.73

    Polar Surface Area:
    84.08

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.66

    DETAILS
  19. ALA5270059

    Name:
    Trans-2-((1R,3R)-3-hydroxycyclopentane-1-carboxamido)-N-(4-phenylpyridin-3-Show More

    Mol. Formula:
    C23H22N4O3

    M.W.:
    402.45

    Type:
    ---

    AlogP:
    3.50

    Polar Surface Area:
    104.21

    HBA:
    5

    HBD:
    3

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.61

    DETAILS
  20. ALA5270055

    Name:
    2-(2-(cyclopropanecarboxamido)pyridin-4-yl)-4-(2-fluoroethoxy)-N,N-dimethylShow More

    Mol. Formula:
    C17H19FN4O3S

    M.W.:
    378.43

    Type:
    ---

    AlogP:
    2.60

    Polar Surface Area:
    84.42

    HBA:
    6

    HBD:
    1

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.80

    DETAILS
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