Compounds

ALA5272443

Name:
7-Cyclopropyl-N-((trans)-4-(R)-1,1,1-trifluoro-3-hydroxypropan-2-yl)amino)cShow More⌵

Mol. Formula:
C21H25F3N4O2

M.W.:
422.45

Type:
---

AlogP:
3.06

Polar Surface Area:
87.14

HBA:
5

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.67

DETAILS

ALA5272062

Name:
(S)-7-(Azetidin-1-yl)-N-(2-oxopyrrolidin-3-yl)-1,8-naphthyridine-3-carboxamShow More⌵

Mol. Formula:
C16H17N5O2

M.W.:
311.35

Type:
---

AlogP:
0.46

Polar Surface Area:
87.22

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.86

DETAILS

ALA5271855

Name:
7-Cyclopropyl-N-((trans)-4-(2-hydroxypropan-2-yl)cyclohexyl)-1,6-naphthyridShow More⌵

Mol. Formula:
C21H27N3O2

M.W.:
353.47

Type:
---

AlogP:
3.57

Polar Surface Area:
75.11

HBA:
4

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.88

DETAILS

ALA5270752

Name:
(S)-7-Cyclopropyl-N-(2-oxopyrrolidin-3-yl)-1,6-naphthyridine-3-carboxamide

Mol. Formula:
C16H16N4O2

M.W.:
296.33

Type:
---

AlogP:
1.13

Polar Surface Area:
83.98

HBA:
4

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.89

DETAILS

ALA5269778

Name:
6-Chloro-7-cyclopropyl-N-((trans)-4-(2-hydroxypropan-2-yl)cyclohexyl)-1,8-nShow More⌵

Mol. Formula:
C21H26ClN3O2

M.W.:
387.91

Type:
---

AlogP:
4.22

Polar Surface Area:
75.11

HBA:
4

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.82

DETAILS

ALA5269001

Name:
N-(trans-4-(2-Hydroxypropan-2-yl)cyclohexyl)-7-((S)-2-methylazetidin-1-yl)-Show More⌵

Mol. Formula:
C22H30N4O2

M.W.:
382.51

Type:
---

AlogP:
3.29

Polar Surface Area:
78.35

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.85

DETAILS

ALA5268479

Name:
6-Chloro-7-cyclopropyl-N-((1s,3s)-3-hydroxy-3-methylcyclobutyl)-1,8-naphthyShow More⌵

Mol. Formula:
C17H18ClN3O2

M.W.:
331.80

Type:
---

AlogP:
2.80

Polar Surface Area:
75.11

HBA:
4

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.91

DETAILS

ALA5268207

Name:
N-(trans)-4-(2-Hydroxypropan-2-yl)cyclohexyl)-6-methoxyquinoxaline-2-carboxShow More⌵

Mol. Formula:
C19H25N3O3

M.W.:
343.43

Type:
---

AlogP:
2.70

Polar Surface Area:
84.34

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.89

DETAILS

ALA5282346

Name:
7-Cyclopropyl-N-(3-(2-hydroxypropan-2-yl)bicyclo[1.1.1]pentan-1-yl)-1,6-napShow More⌵

Mol. Formula:
C20H23N3O2

M.W.:
337.42

Type:
---

AlogP:
2.93

Polar Surface Area:
75.11

HBA:
4

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.90

DETAILS

ALA5282301

Name:
N-(trans-4-(2-Hydroxypropan-2-yl)cyclohexyl)-7-((2,2,2-trifluoroethyl)aminoShow More⌵

Mol. Formula:
C20H25F3N4O2

M.W.:
410.44

Type:
---

AlogP:
3.66

Polar Surface Area:
87.14

HBA:
5

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.70

DETAILS

ALA5282228

Name:
2-Cyclopropyl-N-(trans-4-(2-hydroxypropan-2-yl)cyclohexyl)pyrido[2,3-d]-pyrShow More⌵

Mol. Formula:
C20H26N4O2

M.W.:
354.45

Type:
---

AlogP:
2.96

Polar Surface Area:
88.00

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.88

DETAILS

ALA5281754

Name:
N-(trans-4-(2-Hydroxypropan-2-yl)cyclohexyl)-1,7-naphthyridine-3-carboxamidShow More⌵

Mol. Formula:
C18H23N3O2

M.W.:
313.40

Type:
---

AlogP:
2.69

Polar Surface Area:
75.11

HBA:
4

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.91

DETAILS

ALA5281588

Name:
N-(trans-4-(2-Hydroxypropan-2-yl)cyclohexyl)-7-methoxycinnoline-3-carboxamiShow More⌵

Mol. Formula:
C19H25N3O3

M.W.:
343.43

Type:
---

AlogP:
2.70

Polar Surface Area:
84.34

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.89

DETAILS

ALA5281245

Name:
N-(trans-4-(2-Hydroxypropan-2-yl)cyclohexyl)-6-methoxy-2-naphthamide

Mol. Formula:
C21H27NO3

M.W.:
341.45

Type:
---

AlogP:
3.91

Polar Surface Area:
58.56

HBA:
3

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.89

DETAILS

ALA5280283

Name:
N-(trans-4-(2-Hydroxypropan-2-yl)cyclohexyl)-7-(2,2,2-trifluoroethoxy)-1,8-Show More⌵

Mol. Formula:
C20H24F3N3O3

M.W.:
411.42

Type:
---

AlogP:
3.63

Polar Surface Area:
84.34

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.79

DETAILS

ALA5280247

Name:
7-Cyclopropyl-N-(3-(2-hydroxypropan-2-yl)bicyclo[1.1.1]pentan-1-yl)-1,8-napShow More⌵

Mol. Formula:
C20H23N3O2

M.W.:
337.42

Type:
---

AlogP:
2.93

Polar Surface Area:
75.11

HBA:
4

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.90

DETAILS

ALA5279860

Name:
7-(Azetidin-1-yl)-N-(trans-4-(2-hydroxypropan-2-yl)cyclohexyl)-1,6-naphthyrShow More⌵

Mol. Formula:
C21H28N4O2

M.W.:
368.48

Type:
---

AlogP:
2.90

Polar Surface Area:
78.35

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.87

DETAILS

ALA5279720

Name:
(R)-7-cyclopropyl-N-(6-(2-hydroxypropan-2-yl)spiro[3.3]heptan-2-yl)-1,8-napShow More⌵

Mol. Formula:
C22H27N3O2

M.W.:
365.48

Type:
---

AlogP:
3.57

Polar Surface Area:
75.11

HBA:
4

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.87

DETAILS

ALA5279371

Name:
6-Chloro-N-((1r,4S)-4-hydroxy-4-methylcyclohexyl)-7-((S)-2-methylazetidin-1Show More⌵

Mol. Formula:
C20H25ClN4O2

M.W.:
388.90

Type:
---

AlogP:
3.31

Polar Surface Area:
78.35

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.84

DETAILS

ALA5278680

Name:
6-Chloro-N-((1r,3S)-3-hydroxy-3-methylcyclobutyl)-7-((S)-2-methylazetidin-1Show More⌵

Mol. Formula:
C18H21ClN4O2

M.W.:
360.85

Type:
---

AlogP:
2.53

Polar Surface Area:
78.35

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.88

DETAILS