Compounds

ALA5267690

Name:
(2S)-1-(1-(6-(4-(2-hydroxypropan-2-yl)-2-azabicyclo[2.1.1]hexan-2-yl)pyrimiShow More⌵

Mol. Formula:
C24H26N6O

M.W.:
414.51

Type:
---

AlogP:
3.36

Polar Surface Area:
90.86

HBA:
7

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.70

DETAILS

ALA5267350

Name:
(2R,6S)-2,6-dimethyl-4-(4-(5-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-yl)pyrShow More⌵

Mol. Formula:
C22H24N6O

M.W.:
388.48

Type:
---

AlogP:
3.64

Polar Surface Area:
71.86

HBA:
6

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.58

DETAILS

ALA5267301

Name:
4,5-Dimethyl-N-(3-methyl-1H-indazol-5-yl)-4,7-dihydrotetrazolo[1,5-a]pyrimiShow More⌵

Mol. Formula:
C15H16N8O

M.W.:
324.35

Type:
---

AlogP:
1.22

Polar Surface Area:
104.62

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
2

Passes Ro3:
N

QED Weighted:
0.73

DETAILS

ALA5266868

Name:
N-{7-fluoro-6-[1-(4-hydroxy-3-methyloxolan-3-yl)piperidin-4-yl]isoquinolin-Show More⌵

Mol. Formula:
C28H31FN4O3

M.W.:
490.58

Type:
---

AlogP:
3.84

Polar Surface Area:
87.58

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.57

DETAILS

ALA5266676

Name:
N-(3-Carbamoyl-1H-indazol-5-yl)-4,5-dimethyl-4,7-dihydrotetrazolo[1,5-a]pyrShow More⌵

Mol. Formula:
C15H15N9O2

M.W.:
353.35

Type:
---

AlogP:
0.01

Polar Surface Area:
147.71

HBA:
8

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.60

DETAILS

ALA5266616

Name:
1-(1-(6-(4-(2-hydroxypropan-2-yl)-2-azabicyclo[2.1.1]hexan-2-yl)pyrimidin-4Show More⌵

Mol. Formula:
C25H28N6O

M.W.:
428.54

Type:
---

AlogP:
3.75

Polar Surface Area:
90.86

HBA:
7

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.68

DETAILS

ALA5266092

Name:
1-(1-(6-(4-(2-hydroxypropan-2-yl)-2-azabicyclo[2.1.1]hexan-2-yl)pyrimidin-4Show More⌵

Mol. Formula:
C23H24N6O

M.W.:
400.49

Type:
---

AlogP:
3.11

Polar Surface Area:
90.86

HBA:
7

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.72

DETAILS

ALA5282583

Name:
(R)-2-(1-(6-(6-(1H-pyrazol-5-yl)-1H-indazol-1-yl)pyrimidin-4-yl)pyrrolidin-Show More⌵

Mol. Formula:
C21H23N7O

M.W.:
389.46

Type:
---

AlogP:
2.80

Polar Surface Area:
95.75

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.56

DETAILS

ALA5281154

Name:
(R)-4,5,7-Trimethyl-N-(3-(2-morpholinopyridin-4-yl)-1H-indazol-5-yl)-4,7-diShow More⌵

Mol. Formula:
C24H26N10O2

M.W.:
486.54

Type:
---

AlogP:
2.37

Polar Surface Area:
129.98

HBA:
10

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.45

DETAILS

ALA5280577

Name:
4,5,7,7-Tetramethyl-N-(3-methyl-1H-indazol-5-yl)-4,7-dihydrotetrazolo[1,5-aShow More⌵

Mol. Formula:
C17H20N8O

M.W.:
352.40

Type:
---

AlogP:
1.96

Polar Surface Area:
104.62

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
2

Passes Ro3:
N

QED Weighted:
0.73

DETAILS

ALA5280528

Name:
4,5-Dimethyl-N-(3-methyl-1H-indol-5-yl)-4,7-dihydrotetrazolo[1,5-a]pyrimidiShow More⌵

Mol. Formula:
C16H17N7O

M.W.:
323.36

Type:
---

AlogP:
1.83

Polar Surface Area:
91.73

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
2

Passes Ro3:
N

QED Weighted:
0.75

DETAILS

ALA5280373

Name:
4,5,7,7-Tetramethyl-N-(3-phenyl-1H-indazol-5-yl)-4,7-dihydrotetrazolo[1,5-aShow More⌵

Mol. Formula:
C22H22N8O

M.W.:
414.47

Type:
---

AlogP:
3.31

Polar Surface Area:
104.62

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.53

DETAILS

ALA5280273

Name:
N-(3-Butyramido-1H-indazol-5-yl)-4,5-dimethyl-4,7-dihydrotetrazolo[1,5-a]pyShow More⌵

Mol. Formula:
C18H21N9O2

M.W.:
395.43

Type:
---

AlogP:
1.65

Polar Surface Area:
133.72

HBA:
8

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.60

DETAILS

ALA5279816

Name:
(R)-4,5,7-Trimethyl-N-(3-methyl-1H-indazol-5-yl)-4,7-dihydrotetrazolo[1,5-aShow More⌵

Mol. Formula:
C16H18N8O

M.W.:
338.38

Type:
---

AlogP:
1.78

Polar Surface Area:
104.62

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
2

Passes Ro3:
N

QED Weighted:
0.74

DETAILS

ALA5279765

Name:
(S)-4,5,7-Trimethyl-N-(3-methyl-1H-indazol-5-yl)-4,7-dihydrotetrazolo[1,5-aShow More⌵

Mol. Formula:
C16H18N8O

M.W.:
338.38

Type:
---

AlogP:
1.78

Polar Surface Area:
104.62

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
2

Passes Ro3:
N

QED Weighted:
0.74

DETAILS

ALA5279418

Name:
N-(1H-Indazol-5-yl)-4,5-dimethyl-4H,7H-[1,2,3,4]tetrazolo[1,5-a]pyrimidine-Show More⌵

Mol. Formula:
C14H14N8O

M.W.:
310.32

Type:
---

AlogP:
0.91

Polar Surface Area:
104.62

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
2

Passes Ro3:
N

QED Weighted:
0.73

DETAILS

ALA5279036

Name:
4,5-Dimethyl-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)-4,7-dihydrotetrazolo[1,5-Show More⌵

Mol. Formula:
C19H17N9O

M.W.:
387.41

Type:
---

AlogP:
1.97

Polar Surface Area:
117.51

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.55

DETAILS

ALA5278535

Name:
3-(1-(6-((3R,5S)-3,4,5-trimethylpiperazin-1-yl)pyrimidin-4-yl)-1H-indazol-6Show More⌵

Mol. Formula:
C21H25N7

M.W.:
375.48

Type:
---

AlogP:
2.80

Polar Surface Area:
73.87

HBA:
7

HBD:
---

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.70

DETAILS

ALA5278514

Name:
N-(1H-Indazol-5-yl)-4-methyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxShow More⌵

Mol. Formula:
C13H12N8O

M.W.:
296.29

Type:
---

AlogP:
0.52

Polar Surface Area:
104.62

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
2

Passes Ro3:
N

QED Weighted:
0.71

DETAILS

ALA5277668

Name:
4,5-Dimethyl-N-(3-(2-morpholinopyridin-4-yl)-1H-indazol-5-yl)-4,7-dihydroteShow More⌵

Mol. Formula:
C23H24N10O2

M.W.:
472.51

Type:
---

AlogP:
1.81

Polar Surface Area:
129.98

HBA:
10

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.46

DETAILS