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  1. ALA5272585

    Name:
    (1R,3S)-3-(3-((3H-imidazo[4,5-c]pyridin-4-yl)amino)-1H-pyrazol-5-yl)cyclopeShow More

    Mol. Formula:
    C18H23N7O2

    M.W.:
    369.43

    Type:
    ---

    AlogP:
    3.20

    Polar Surface Area:
    120.61

    HBA:
    6

    HBD:
    4

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.55

    DETAILS
  2. ALA5271882

    Name:
    8-Cyclopentyl-2-{[1-(methanesulfonyl)piperidin-4-yl]amino}-pyrido[2,3-d]pyrShow More

    Mol. Formula:
    C18H25N5O3S

    M.W.:
    391.50

    Type:
    ---

    AlogP:
    1.74

    Polar Surface Area:
    97.19

    HBA:
    7

    HBD:
    1

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.85

    DETAILS
  3. ALA5271753

    Name:
    6-Chloro-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methanesulfonyl)pShow More

    Mol. Formula:
    C19H26ClN5O4S

    M.W.:
    455.97

    Type:
    ---

    AlogP:
    1.76

    Polar Surface Area:
    117.42

    HBA:
    8

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.72

    DETAILS
  4. ALA5271375

    Name:
    (S)-2-((4-((6-(((4,6-dimethylpyridin-3-yl)methyl)amino)pyrimidin-4-yl)(isopShow More

    Mol. Formula:
    C24H32N6O

    M.W.:
    420.56

    Type:
    ---

    AlogP:
    4.44

    Polar Surface Area:
    86.20

    HBA:
    7

    HBD:
    3

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    9

    Passes Ro3:
    N

    QED Weighted:
    0.47

    DETAILS
  5. ALA5271228

    Name:
    (1R,3S)-3-(2-(1-methyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)cycloShow More

    Mol. Formula:
    C20H25N5O2

    M.W.:
    367.45

    Type:
    ---

    AlogP:
    3.73

    Polar Surface Area:
    84.83

    HBA:
    5

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.74

    DETAILS
  6. ALA5270806

    Name:
    6-(Pentylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl benzoate

    Mol. Formula:
    C17H18N4O2S

    M.W.:
    342.42

    Type:
    ---

    AlogP:
    3.85

    Polar Surface Area:
    80.76

    HBA:
    6

    HBD:
    1

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.30

    DETAILS
  7. ALA5270220

    Name:
    (1(1S),1(3R),Z)-2(1)H-6,12-dioxa-3,10-diaza-4(2,6)-pyridina-2(5,3)-pyrazolaShow More

    Mol. Formula:
    C18H23N5O3

    M.W.:
    357.41

    Type:
    ---

    AlogP:
    2.83

    Polar Surface Area:
    101.16

    HBA:
    6

    HBD:
    3

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    ---

    Passes Ro3:
    N

    QED Weighted:
    0.67

    DETAILS
  8. ALA5269912

    Name:
    8-Cyclopentyl-6-(hydroxymethyl)-2-{[1-(methanesulfonyl)-piperidin-4-yl]aminShow More

    Mol. Formula:
    C19H27N5O4S

    M.W.:
    421.52

    Type:
    ---

    AlogP:
    1.23

    Polar Surface Area:
    117.42

    HBA:
    8

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.75

    DETAILS
  9. ALA5269336

    Name:
    8-Cycloheptyl-2-{[1-(methanesulfonyl)piperidin-4-yl]amino}-pyrido[2,3-d]pyrShow More

    Mol. Formula:
    C20H29N5O3S

    M.W.:
    419.55

    Type:
    ---

    AlogP:
    2.52

    Polar Surface Area:
    97.19

    HBA:
    7

    HBD:
    1

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.77

    DETAILS
  10. ALA5269057

    Name:
    N-(5-(3-cyclopentyl-5-methylphenyl)-1H-pyrazol-3-yl)-1-(methylsulfonyl)pipeShow More

    Mol. Formula:
    C21H30N4O2S

    M.W.:
    402.56

    Type:
    ---

    AlogP:
    3.88

    Polar Surface Area:
    78.09

    HBA:
    4

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.80

    DETAILS
  11. ALA5268589

    Name:
    N-(2-chlorophenyl)-6-(phenethylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

    Mol. Formula:
    C19H16ClN5S

    M.W.:
    381.89

    Type:
    ---

    AlogP:
    5.08

    Polar Surface Area:
    66.49

    HBA:
    5

    HBD:
    2

    #RO5 Violations:
    1

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.36

    DETAILS
  12. ALA5268336

    Name:
    6-(Pentylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl 3,3-dimethylbutanoate

    Mol. Formula:
    C16H24N4O2S

    M.W.:
    336.46

    Type:
    ---

    AlogP:
    3.98

    Polar Surface Area:
    80.76

    HBA:
    6

    HBD:
    1

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.36

    DETAILS
  13. ALA5268323

    Name:
    (1R,3S)-3-(3-((6-(methylcarbamoyl)pyridin-2-yl)amino)-1H-pyrazol-5-yl)cycloShow More

    Mol. Formula:
    C19H26N6O3

    M.W.:
    386.46

    Type:
    ---

    AlogP:
    2.68

    Polar Surface Area:
    121.03

    HBA:
    6

    HBD:
    4

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.61

    DETAILS
  14. ALA5267779

    Name:
    5-(1-(4-hydroxyphenyl)-5-phenyl-1H-pyrazolo[4,3-e][1,2,4]triazin-3-yl)benzeShow More

    Mol. Formula:
    C22H15N5O4

    M.W.:
    413.39

    Type:
    ---

    AlogP:
    3.37

    Polar Surface Area:
    137.41

    HBA:
    9

    HBD:
    4

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    3

    Passes Ro3:
    N

    QED Weighted:
    0.33

    DETAILS
  15. ALA5281860

    Name:
    6-(2-Fluoropropyl)-8-((1R,2R)-2-hydroxy-2-methylcyclopentyl)-2-((1-(methylsShow More

    Mol. Formula:
    C21H29F2N5O4S

    M.W.:
    485.56

    Type:
    ---

    AlogP:
    1.91

    Polar Surface Area:
    117.42

    HBA:
    8

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    6

    Passes Ro3:
    N

    QED Weighted:
    0.64

    DETAILS
  16. ALA5281770

    Name:
    2-{[1-(Methanesulfonyl)piperidin-4-yl]amino}-8-[(1R,2S)-2-methylcyclopentylShow More

    Mol. Formula:
    C19H27N5O3S

    M.W.:
    405.52

    Type:
    ---

    AlogP:
    1.99

    Polar Surface Area:
    97.19

    HBA:
    7

    HBD:
    1

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.84

    DETAILS
  17. ALA5281457

    Name:
    6-bromo-7-(isopropylamino)-2-(4-(methylsulfonyl)phenyl)pyrido[2,3-d]pyrimidShow More

    Mol. Formula:
    C17H17BrN4O3S

    M.W.:
    437.32

    Type:
    ---

    AlogP:
    2.97

    Polar Surface Area:
    104.81

    HBA:
    6

    HBD:
    2

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    4

    Passes Ro3:
    N

    QED Weighted:
    0.65

    DETAILS
  18. ALA5280948

    Name:
    N-(4-(methylthio)phenyl)-6-(pentylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

    Mol. Formula:
    C17H21N5S2

    M.W.:
    359.52

    Type:
    ---

    AlogP:
    5.10

    Polar Surface Area:
    66.49

    HBA:
    6

    HBD:
    2

    #RO5 Violations:
    1

    #Rotatable Bonds:
    8

    Passes Ro3:
    N

    QED Weighted:
    0.33

    DETAILS
  19. ALA5280936

    Name:
    6-(Pentylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl benzofuran-2-carboxylate

    Mol. Formula:
    C19H18N4O3S

    M.W.:
    382.45

    Type:
    ---

    AlogP:
    4.60

    Polar Surface Area:
    93.90

    HBA:
    7

    HBD:
    1

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    7

    Passes Ro3:
    N

    QED Weighted:
    0.22

    DETAILS
  20. ALA5280928

    Name:
    6-Acetyl-8-cyclopentyl-2-{[1-(methanesulfonyl)piperidin-4-yl]-amino}-5-methShow More

    Mol. Formula:
    C21H29N5O4S

    M.W.:
    447.56

    Type:
    ---

    AlogP:
    2.25

    Polar Surface Area:
    114.26

    HBA:
    8

    HBD:
    1

    #RO5 Violations:
    ---

    #Rotatable Bonds:
    5

    Passes Ro3:
    N

    QED Weighted:
    0.70

    DETAILS
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