Compounds

ALA5272522

Name:
(1S,4S)-ethyl 5-(4-(5-amino-6-(difluoromethoxy)pyrazin-2-yl)-6-(2-azabicyclShow More⌵

Mol. Formula:
C22H26F2N8O3

M.W.:
488.50

Type:
---

AlogP:
2.14

Polar Surface Area:
122.83

HBA:
10

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.65

DETAILS

ALA5271972

Name:
5-(2-(2-azabicyclo[2.1.1]hexan-2-yl)-6-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heShow More⌵

Mol. Formula:
C19H21F2N7O2

M.W.:
417.42

Type:
---

AlogP:
1.69

Polar Surface Area:
102.52

HBA:
9

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.78

DETAILS

ALA5271665

Name:
3-(difluoromethoxy)-5-(6-(3,3-difluoropyrrolidin-1-yl)-2-((1S,4S)-5-(6-methShow More⌵

Mol. Formula:
C23H24F4N10O

M.W.:
532.51

Type:
---

AlogP:
2.53

Polar Surface Area:
122.31

HBA:
11

HBD:
1

#RO5 Violations:
2

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.47

DETAILS

ALA5270353

Name:
5-(2-(6-oxa-3-azabicyclo[3.1.1]heptan-3-yl)-6-(3,3-difluoropyrrolidin-1-yl)Show More⌵

Mol. Formula:
C18H19F4N7O2

M.W.:
441.39

Type:
---

AlogP:
1.94

Polar Surface Area:
102.52

HBA:
9

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.70

DETAILS

ALA5269792

Name:
5-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-6-((R)-tetrahydrofuran-Show More⌵

Mol. Formula:
C18H20F2N6O3

M.W.:
406.39

Type:
---

AlogP:
1.95

Polar Surface Area:
108.51

HBA:
9

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.80

DETAILS

ALA5269484

Name:
5-(6-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-4-cyclopropylpyridin-2-Show More⌵

Mol. Formula:
C18H19F2N5O2

M.W.:
375.38

Type:
---

AlogP:
2.58

Polar Surface Area:
86.39

HBA:
7

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.86

DETAILS

ALA5268969

Name:
5-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-6-(3,3-difluoropyrrolidShow More⌵

Mol. Formula:
C19H20F4N6O2

M.W.:
440.40

Type:
---

AlogP:
2.55

Polar Surface Area:
89.63

HBA:
8

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.71

DETAILS

ALA5268950

Name:
5-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-6-(methylthio)pyrimidinShow More⌵

Mol. Formula:
C15H16F2N6O2S

M.W.:
382.40

Type:
---

AlogP:
1.82

Polar Surface Area:
99.28

HBA:
9

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.61

DETAILS

ALA5281886

Name:
5-(2-(2-azabicyclo[2.1.1]hexan-2-yl)-6-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heShow More⌵

Mol. Formula:
C18H21N7O

M.W.:
351.41

Type:
---

AlogP:
1.09

Polar Surface Area:
93.29

HBA:
8

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.88

DETAILS

ALA5281494

Name:
(1S,4S)-methyl 5-(4-(5-amino-6-(difluoromethoxy)pyrazin-2-yl)-6-(2-azabicycShow More⌵

Mol. Formula:
C22H25F2N7O3

M.W.:
473.48

Type:
---

AlogP:
2.35

Polar Surface Area:
109.94

HBA:
9

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.70

DETAILS

ALA5278476

Name:
5-(3-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-5-cyclopropylphenyl)-3-Show More⌵

Mol. Formula:
C19H20F2N4O2

M.W.:
374.39

Type:
---

AlogP:
3.18

Polar Surface Area:
73.50

HBA:
6

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.87

DETAILS

ALA5278185

Name:
5-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-6-cyclopropylpyrimidin-Show More⌵

Mol. Formula:
C17H18F2N6O2

M.W.:
376.37

Type:
---

AlogP:
1.97

Polar Surface Area:
99.28

HBA:
8

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.85

DETAILS

ALA5277751

Name:
5-(6-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-2-(3,3-difluoropyrrolidShow More⌵

Mol. Formula:
C18H19F4N7O2

M.W.:
441.39

Type:
---

AlogP:
1.94

Polar Surface Area:
102.52

HBA:
9

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.70

DETAILS

ALA5277276

Name:
5-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-6-cyclopropylpyridin-4-Show More⌵

Mol. Formula:
C18H19F2N5O2

M.W.:
375.38

Type:
---

AlogP:
2.58

Polar Surface Area:
86.39

HBA:
7

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.86

DETAILS

ALA5276415

Name:
5-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-6-((S)-tetrahydrofuran-Show More⌵

Mol. Formula:
C18H20F2N6O3

M.W.:
406.39

Type:
---

AlogP:
1.95

Polar Surface Area:
108.51

HBA:
9

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.80

DETAILS

ALA5276337

Name:
5-(6-(2-azabicyclo[2.1.1]hexan-2-yl)-2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heShow More⌵

Mol. Formula:
C19H21F2N7O2

M.W.:
417.42

Type:
---

AlogP:
1.69

Polar Surface Area:
102.52

HBA:
9

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.78

DETAILS

ALA5273015

Name:
5-(2-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-6-(3,3-difluoropyrrolidShow More⌵

Mol. Formula:
C18H19F4N7O2

M.W.:
441.39

Type:
---

AlogP:
1.94

Polar Surface Area:
102.52

HBA:
9

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.70

DETAILS

ALA5286166

Name:
(1S,4S)-ethyl 5-(4-(5-amino-6-(difluoromethoxy)pyrazin-2-yl)-6-(3,3-difluorShow More⌵

Mol. Formula:
C21H24F4N8O3

M.W.:
512.47

Type:
---

AlogP:
2.38

Polar Surface Area:
122.83

HBA:
10

HBD:
1

#RO5 Violations:
1

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.58

DETAILS

ALA5284890

Name:
5-(2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-6-(3,3-difluoropyrrolidShow More⌵

Mol. Formula:
C18H19F4N7O2

M.W.:
441.39

Type:
---

AlogP:
1.94

Polar Surface Area:
102.52

HBA:
9

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.70

DETAILS

ALA5284496

Name:
5-(2-(2-azabicyclo[2.1.1]hexan-2-yl)-6-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heShow More⌵

Mol. Formula:
C19H20F3N7O

M.W.:
419.41

Type:
---

AlogP:
2.11

Polar Surface Area:
93.29

HBA:
8

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.81

DETAILS