Type:
Small moleculeAlogP:
3.40Polar Surface Area:
81.34HBA:
5HBD:
1#RO5 Violations:
---#Rotatable Bonds:
3Passes Ro3:
NQED Weighted:
0.77DETAILS
Type:
Small moleculeAlogP:
2.48Polar Surface Area:
103.02HBA:
6HBD:
2#RO5 Violations:
---#Rotatable Bonds:
4Passes Ro3:
NQED Weighted:
0.75DETAILS
Type:
Small moleculeAlogP:
1.72Polar Surface Area:
125.14HBA:
8HBD:
2#RO5 Violations:
---#Rotatable Bonds:
5Passes Ro3:
NQED Weighted:
0.68DETAILS
Type:
Small moleculeAlogP:
2.32Polar Surface Area:
112.25HBA:
7HBD:
2#RO5 Violations:
---#Rotatable Bonds:
5Passes Ro3:
NQED Weighted:
0.70DETAILS
ALA1783283Name:
4-amino-8-(2,4-dimethoxyphenyl)-7-fluoro-N-propylcinnoline-3-carboxamideMol. Formula:
C20H21FN4O3M.W.:
384.41Type:
Small moleculeAlogP:
3.18Polar Surface Area:
99.36HBA:
6HBD:
2#RO5 Violations:
---#Rotatable Bonds:
6Passes Ro3:
NQED Weighted:
0.68DETAILS- AZD-7325
Name:
4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamideMol. Formula:
C19H19FN4O2M.W.:
354.39Type:
Small moleculeAlogP:
3.17Polar Surface Area:
90.13HBA:
5HBD:
2#RO5 Violations:
---#Rotatable Bonds:
5Passes Ro3:
NQED Weighted:
0.73DETAILS - ALA1783281
Name:
4-amino-8-(2-methoxy-5-methylphenyl)-N-propylcinnoline-3-carboxamideMol. Formula:
C20H22N4O2M.W.:
350.42Type:
Small moleculeAlogP:
3.34Polar Surface Area:
90.13HBA:
5HBD:
2#RO5 Violations:
---#Rotatable Bonds:
5Passes Ro3:
NQED Weighted:
0.74DETAILS - ALA1783280
Name:
4-amino-8-(4-methoxypyridin-3-yl)-N-propylcinnoline-3-carboxamideMol. Formula:
C18H19N5O2M.W.:
337.38Type:
Small moleculeAlogP:
2.42Polar Surface Area:
103.02HBA:
6HBD:
2#RO5 Violations:
---#Rotatable Bonds:
5Passes Ro3:
NQED Weighted:
0.74DETAILS - ALA1783279
Name:
4-amino-8-(2,4-dimethoxypyrimidin-5-yl)-N-propylcinnoline-3-carboxamideMol. Formula:
C18H20N6O3M.W.:
368.40Type:
Small moleculeAlogP:
1.83Polar Surface Area:
125.14HBA:
8HBD:
2#RO5 Violations:
---#Rotatable Bonds:
6Passes Ro3:
NQED Weighted:
0.67DETAILS -
Type:
Small moleculeAlogP:
3.62Polar Surface Area:
77.68HBA:
5HBD:
1#RO5 Violations:
---#Rotatable Bonds:
4Passes Ro3:
NQED Weighted:
0.75DETAILS -
Type:
Small moleculeAlogP:
3.76Polar Surface Area:
77.68HBA:
5HBD:
1#RO5 Violations:
---#Rotatable Bonds:
4Passes Ro3:
NQED Weighted:
0.73DETAILS -
Type:
Small moleculeAlogP:
4.15Polar Surface Area:
77.68HBA:
5HBD:
1#RO5 Violations:
---#Rotatable Bonds:
4Passes Ro3:
NQED Weighted:
0.70DETAILS - ALA1783275
Name:
4-amino-8-(2,5-dimethoxyphenyl)-7-fluoro-N-isopropylcinnoline-3-carboxamideMol. Formula:
C20H21FN4O3M.W.:
384.41Type:
Small moleculeAlogP:
3.17Polar Surface Area:
99.36HBA:
6HBD:
2#RO5 Violations:
---#Rotatable Bonds:
5Passes Ro3:
NQED Weighted:
0.70DETAILS - ALA1783274
Name:
4-amino-8-(2,5-dimethoxyphenyl)-N-ethyl-7-fluorocinnoline-3-carboxamideMol. Formula:
C19H19FN4O3M.W.:
370.38Type:
Small moleculeAlogP:
2.79Polar Surface Area:
99.36HBA:
6HBD:
2#RO5 Violations:
---#Rotatable Bonds:
5Passes Ro3:
NQED Weighted:
0.72DETAILS -
Type:
Small moleculeAlogP:
3.32Polar Surface Area:
99.36HBA:
6HBD:
2#RO5 Violations:
---#Rotatable Bonds:
5Passes Ro3:
NQED Weighted:
0.69DETAILS - ALA1783272
Name:
4-amino-8-(2,5-dimethoxyphenyl)-7-fluoro-N-propylcinnoline-3-carboxamideMol. Formula:
C20H21FN4O3M.W.:
384.41Type:
Small moleculeAlogP:
3.18Polar Surface Area:
99.36HBA:
6HBD:
2#RO5 Violations:
---#Rotatable Bonds:
6Passes Ro3:
NQED Weighted:
0.68DETAILS -
Type:
Small moleculeAlogP:
2.93Polar Surface Area:
99.36HBA:
6HBD:
2#RO5 Violations:
---#Rotatable Bonds:
5Passes Ro3:
NQED Weighted:
0.70DETAILS -
Type:
Small moleculeAlogP:
3.62Polar Surface Area:
77.68HBA:
5HBD:
1#RO5 Violations:
---#Rotatable Bonds:
4Passes Ro3:
NQED Weighted:
0.75DETAILS -
Type:
Small moleculeAlogP:
4.01Polar Surface Area:
77.68HBA:
5HBD:
1#RO5 Violations:
---#Rotatable Bonds:
4Passes Ro3:
NQED Weighted:
0.73DETAILS -
Type:
Small moleculeAlogP:
3.09Polar Surface Area:
77.68HBA:
5HBD:
1#RO5 Violations:
---#Rotatable Bonds:
3Passes Ro3:
NQED Weighted:
0.79DETAILS
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