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ALA5270747 Name:
2-amino-4-(4-(dimethylamino)phenyl)-6-(4-hydroxy-2-oxo-2H-chromen-3-yl)nicoShow More⌵
Mol. Formula:
C23H18N4O3
M.W.:
398.42
Type:
---
AlogP:
3.75
Polar Surface Area:
116.38
HBA:
7
HBD:
2
#RO5 Violations:
---
#Rotatable Bonds:
3
Passes Ro3:
N
QED Weighted:
0.50
DETAILS
CLOSE
ALA5273069 Name:
7-cyclopentyl-2-[4-[2-(dimethylamino)ethylcarbamoyl]-2-fluoro-anilino]-N,N-Show More⌵
Mol. Formula:
C25H32FN7O2
M.W.:
481.58
Type:
---
AlogP:
3.42
Polar Surface Area:
95.39
HBA:
7
HBD:
2
#RO5 Violations:
---
#Rotatable Bonds:
8
Passes Ro3:
N
QED Weighted:
0.51
DETAILS
CLOSE
ALA5284719 Name:
N-(3-((4-((2,6-difluorophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenyl)-3Show More⌵
Mol. Formula:
C21H21F3N6O
M.W.:
430.43
Type:
---
AlogP:
4.27
Polar Surface Area:
82.18
HBA:
6
HBD:
3
#RO5 Violations:
---
#Rotatable Bonds:
8
Passes Ro3:
N
QED Weighted:
0.50
DETAILS
CLOSE
ALA5208459 Name:
4-ethyl-6-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl)amino)-8-(mShow More⌵
Mol. Formula:
C26H27F2N5O4
M.W.:
511.53
Type:
---
AlogP:
3.75
Polar Surface Area:
89.05
HBA:
8
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
7
Passes Ro3:
N
QED Weighted:
0.51
DETAILS
CLOSE
ALA5207141 Name:
8-((4-acetylpiperazin-1-yl)methyl)-4-methyl-6-((5-fluoro-4-(4-fluoro-2-methShow More⌵
Mol. Formula:
C28H30F2N6O4
M.W.:
552.58
Type:
---
AlogP:
3.58
Polar Surface Area:
100.13
HBA:
8
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
7
Passes Ro3:
N
QED Weighted:
0.48
DETAILS
CLOSE
ALA5206405 Name:
4-ethyl-6-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl)amino)-8-((Show More⌵
Mol. Formula:
C29H34F2N6O3
M.W.:
552.63
Type:
---
AlogP:
4.45
Polar Surface Area:
83.06
HBA:
8
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
8
Passes Ro3:
N
QED Weighted:
0.44
DETAILS
CLOSE
ALA5206344 Name:
4-ethyl-6-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl)amino)-8-((Show More⌵
Mol. Formula:
C26H30F2N6O3
M.W.:
512.56
Type:
---
AlogP:
3.57
Polar Surface Area:
91.85
HBA:
8
HBD:
2
#RO5 Violations:
1
#Rotatable Bonds:
10
Passes Ro3:
N
QED Weighted:
0.43
DETAILS
CLOSE
ALA5204512 Name:
8-((diethylamino)methyl)-4-ethyl-6-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pShow More⌵
Mol. Formula:
C26H29F2N5O3
M.W.:
497.55
Type:
---
AlogP:
4.76
Polar Surface Area:
79.82
HBA:
7
HBD:
1
#RO5 Violations:
---
#Rotatable Bonds:
9
Passes Ro3:
N
QED Weighted:
0.46
DETAILS
CLOSE
ALA5203771 Name:
6-((5-chloro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)-4-ethyl-8-(morShow More⌵
Mol. Formula:
C27H28ClFN4O4
M.W.:
527.00
Type:
---
AlogP:
4.87
Polar Surface Area:
76.16
HBA:
7
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
7
Passes Ro3:
N
QED Weighted:
0.47
DETAILS
CLOSE
ALA5201583 Name:
4-ethyl-6-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl)amino)-8-((Show More⌵
Mol. Formula:
C27H30F2N6O5S
M.W.:
588.64
Type:
---
AlogP:
3.00
Polar Surface Area:
117.20
HBA:
9
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
8
Passes Ro3:
N
QED Weighted:
0.42
DETAILS
CLOSE
ALA5201460 Name:
4-ethyl-6-((4-(3-isopropyl-2-methyl-2H-indazol-5-yl)pyrimidin-2-yl)amino)-8Show More⌵
Mol. Formula:
C30H35N7O3
M.W.:
541.66
Type:
---
AlogP:
4.47
Polar Surface Area:
97.64
HBA:
9
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
7
Passes Ro3:
N
QED Weighted:
0.37
DETAILS
CLOSE
ALA5200954 Name:
4-ethyl-6((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)-8-(morpShow More⌵
Mol. Formula:
C27H28F2N4O4
M.W.:
510.54
Type:
---
AlogP:
4.36
Polar Surface Area:
76.16
HBA:
7
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
7
Passes Ro3:
N
QED Weighted:
0.51
DETAILS
CLOSE
ALA5200301 Name:
4-ethyl-6-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl)amino)-8-(tShow More⌵
Mol. Formula:
C26H27F2N5O3S
M.W.:
527.60
Type:
---
AlogP:
4.47
Polar Surface Area:
79.82
HBA:
8
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
7
Passes Ro3:
N
QED Weighted:
0.48
DETAILS
CLOSE
ALA5200273 Name:
4-ethyl-6-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl)amino)-8-(pShow More⌵
Mol. Formula:
C26H28F2N6O3
M.W.:
510.55
Type:
---
AlogP:
3.32
Polar Surface Area:
91.85
HBA:
8
HBD:
2
#RO5 Violations:
1
#Rotatable Bonds:
7
Passes Ro3:
N
QED Weighted:
0.50
DETAILS
CLOSE
ALA5199065 Name:
(1S,3S)-N1-(5-(pentan-3-yl)pyrazolo[1,5-a]pyrimidin-7-yl)cyclopentane-1,3-dShow More⌵
Mol. Formula:
C16H25N5
M.W.:
287.41
Type:
---
AlogP:
2.92
Polar Surface Area:
68.24
HBA:
5
HBD:
2
#RO5 Violations:
---
#Rotatable Bonds:
5
Passes Ro3:
N
QED Weighted:
0.89
DETAILS
CLOSE
ALA5197862 Name:
4-ethyl-6-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl)amino)-8-((Show More⌵
Mol. Formula:
C26H29F2N5O4
M.W.:
513.55
Type:
---
AlogP:
4.00
Polar Surface Area:
89.05
HBA:
8
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
10
Passes Ro3:
N
QED Weighted:
0.44
DETAILS
CLOSE
ALA5196603 Name:
4-ethyl-6-((4-(4-fluoro-2-methoxyphenyl)pyrimidin-2-yl)amino)-8-(morpholinoShow More⌵
Mol. Formula:
C26H28FN5O4
M.W.:
493.54
Type:
---
AlogP:
3.61
Polar Surface Area:
89.05
HBA:
8
HBD:
1
#RO5 Violations:
---
#Rotatable Bonds:
7
Passes Ro3:
N
QED Weighted:
0.53
DETAILS
CLOSE
ALA5196054 Name:
8-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-4-ethyl-6-((5-fluoro-4-(4-fluoShow More⌵
Mol. Formula:
C28H32F2N6O3
M.W.:
538.60
Type:
---
AlogP:
4.06
Polar Surface Area:
83.06
HBA:
8
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
8
Passes Ro3:
N
QED Weighted:
0.46
DETAILS
CLOSE
ALA5194679 Name:
4-ethyl-6-((4-(1-isopropyl-2-methyl-1H-benzo[d]imidazole-6-yl)pyrinddin-2-yShow More⌵
Mol. Formula:
C30H35N7O3
M.W.:
541.66
Type:
---
AlogP:
4.70
Polar Surface Area:
97.64
HBA:
9
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
7
Passes Ro3:
N
QED Weighted:
0.36
DETAILS
CLOSE
ALA5190233 Name:
8-((1,1-dioxidothiomorpholino)methyl)-4-ethyl-6-((5-fluoro-4-(4-fluoro-2-meShow More⌵
Mol. Formula:
C26H27F2N5O5S
M.W.:
559.60
Type:
---
AlogP:
3.15
Polar Surface Area:
113.96
HBA:
9
HBD:
1
#RO5 Violations:
1
#Rotatable Bonds:
7
Passes Ro3:
N
QED Weighted:
0.47
DETAILS
CLOSE
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