Compounds

Type:
Small molecule

AlogP:
2.09

Polar Surface Area:
96.26

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.57

DETAILS

ALA1956686

Name:
4-(8-(4-(4-methylpiperazin-1-yl)phenylamino)imidazo[1,2-a]pyrazin-5-yl)pyriShow More⌵

Mol. Formula:
C22H23N7O

M.W.:
401.47

Type:
Small molecule

AlogP:
2.58

Polar Surface Area:
81.56

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.55

DETAILS

ALA1956685

Name:
4-(8-(4-morpholinophenylamino)imidazo[1,2-a]pyrazin-5-yl)furan-2-carboxamidShow More⌵

Mol. Formula:
C21H20N6O3

M.W.:
404.43

Type:
Small molecule

AlogP:
2.67

Polar Surface Area:
110.92

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.53

DETAILS

ALA1956684

Name:
5-(8-(4-morpholinophenylamino)imidazo[1,2-a]pyrazin-5-yl)furan-3-carboxamidShow More⌵

Mol. Formula:
C21H20N6O3

M.W.:
404.43

Type:
Small molecule

AlogP:
2.67

Polar Surface Area:
110.92

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.53

DETAILS

ALA1956683

Name:
4-(8-(4-(4-methylpiperazin-1-yl)phenylamino)-[1,2,4]triazolo[1,5-a]pyrazin-Show More⌵

Mol. Formula:
C21H22N8O

M.W.:
402.46

1 activity values

Type:
Small molecule

AlogP:
1.98

Polar Surface Area:
94.45

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.54

DETAILS

ALA1956682

Name:
5-(8-(4-morpholinophenylamino)-[1,2,4]triazolo[1,5-a]pyrazin-5-yl)isoindoliShow More⌵

Mol. Formula:
C23H21N7O2

M.W.:
427.47

Type:
Small molecule

AlogP:
2.61

Polar Surface Area:
96.68

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.52

DETAILS

ALA1956575

Name:
5-(1H-indol-5-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine

Mol. Formula:
C24H22N6O

M.W.:
410.48

Type:
Small molecule

AlogP:
4.46

Polar Surface Area:
70.48

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.46

DETAILS

ALA1956574

Name:
5-(8-(4-morpholinophenylamino)imidazo[1,2-a]pyrazin-5-yl)isoindolin-1-one

Mol. Formula:
C24H22N6O2

M.W.:
426.48

Type:
Small molecule

AlogP:
3.22

Polar Surface Area:
83.79

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.52

DETAILS

ALA1956573

Name:
4-(8-(4-morpholinophenylamino)imidazo[1,2-a]pyrazin-5-yl)thiophene-2-carboxShow More⌵

Mol. Formula:
C21H20N6O2S

M.W.:
420.50

Type:
Small molecule

AlogP:
3.14

Polar Surface Area:
97.78

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.51

DETAILS

ALA1956572

Name:
5-(8-(4-morpholinophenylamino)imidazo[1,2-a]pyrazin-5-yl)thiazole-2-carboxaShow More⌵

Mol. Formula:
C20H19N7O2S

M.W.:
421.49

Type:
Small molecule

AlogP:
2.53

Polar Surface Area:
110.67

HBA:
9

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.51

DETAILS

ALA1956571

Name:
2-(8-(4-morpholinophenylamino)imidazo[1,2-a]pyrazin-5-yl)thiazole-5-carboxaShow More⌵

Mol. Formula:
C20H19N7O2S

M.W.:
421.49

Type:
Small molecule

AlogP:
2.53

Polar Surface Area:
110.67

HBA:
9

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.51

DETAILS

ALA1956570

Name:
5-(8-(4-morpholinophenylamino)imidazo[1,2-a]pyrazin-5-yl)thiophene-2-carboxShow More⌵

Mol. Formula:
C21H20N6O2S

M.W.:
420.50

Type:
Small molecule

AlogP:
3.14

Polar Surface Area:
97.78

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.51

DETAILS

ALA1956569

Name:
5-(2-(dimethylamino)pyridin-4-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazShow More⌵

Mol. Formula:
C23H25N7O

M.W.:
415.50

Type:
Small molecule

AlogP:
3.44

Polar Surface Area:
70.82

HBA:
8

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.54

DETAILS

ALA1956568

Name:
5-(2-ethoxypyridin-4-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-aminShow More⌵

Mol. Formula:
C23H24N6O2

M.W.:
416.49

Type:
Small molecule

AlogP:
3.77

Polar Surface Area:
76.81

HBA:
8

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.51

DETAILS

ALA1956567

Name:
4-(8-(4-morpholinophenylamino)imidazo[1,2-a]pyrazin-5-yl)pyridin-2(1H)-one

Mol. Formula:
C21H20N6O2

M.W.:
388.43

Type:
Small molecule

AlogP:
2.66

Polar Surface Area:
87.55

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.56

DETAILS

ALA1956566

Name:
2-fluoro-4-(8-(4-morpholinophenylamino)imidazo[1,2-a]pyrazin-5-yl)benzamide

Mol. Formula:
C23H21FN6O2

M.W.:
432.46

Type:
Small molecule

AlogP:
3.21

Polar Surface Area:
97.78

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.50

DETAILS

ALA1956565

Name:
4-(8-(4-morpholinophenylamino)imidazo[1,2-a]pyrazin-5-yl)benzenesulfonamide

Mol. Formula:
C22H22N6O3S

M.W.:
450.52

Type:
Small molecule

AlogP:
2.62

Polar Surface Area:
114.85

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.48

DETAILS

ALA1956564

Name:
4-(8-(4-morpholinophenylamino)imidazo[1,2-a]pyrazin-5-yl)benzamide

Mol. Formula:
C23H22N6O2

M.W.:
414.47

Type:
Small molecule

AlogP:
3.08

Polar Surface Area:
97.78

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.52

DETAILS

ALA1956563

Name:
N-(4-morpholinophenyl)-5-(1H-1,2,3-triazol-4-yl)imidazo[1,2-a]pyrazin-8-amiShow More⌵

Mol. Formula:
C18H18N8O

M.W.:
362.40

Type:
Small molecule

AlogP:
2.09

Polar Surface Area:
96.26

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.57

DETAILS

ALA1956562

Name:
N-methyl-N-(4-morpholinophenyl)-5-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-Show More⌵

Mol. Formula:
C20H21N7O

M.W.:
375.44