Compounds

Type:
Unknown

AlogP:
3.05

Polar Surface Area:
152.37

HBA:
9

HBD:
3

#RO5 Violations:
1

#Rotatable Bonds:
18

Passes Ro3:
N

QED Weighted:
0.16

DETAILS

ALA4520562

Name:
2-Adamantan-1-yl-N-[3-(4-{3-[2-(2,6-dioxo-piperidin-3-yl)-1,3-dioxo-2,3-dihShow More⌵

Mol. Formula:
C35H48N4O7

M.W.:
636.79

Type:
Unknown

AlogP:
3.82

Polar Surface Area:
143.14

HBA:
8

HBD:
3

#RO5 Violations:
1

#Rotatable Bonds:
17

Passes Ro3:
N

QED Weighted:
0.17

DETAILS

ALA4516967

Name:
2-Adamantan-1-yl-N-{2-[2-(2-{2-[2-(2,6-dioxo-piperidin-3-yl)-1,3-dioxo-2,3-Show More⌵

Mol. Formula:
C33H44N4O8

M.W.:
624.74

Type:
Unknown

AlogP:
2.27

Polar Surface Area:
152.37

HBA:
9

HBD:
3

#RO5 Violations:
1

#Rotatable Bonds:
16

Passes Ro3:
N

QED Weighted:
0.19

DETAILS

ALA4476348

Name:
3-(6-amino-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)piperidine-2,6-dione

Mol. Formula:
C12H11N5O3

M.W.:
273.25

Type:
Unknown

AlogP:
-0.65

Polar Surface Area:
119.97

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
1

Passes Ro3:
N

QED Weighted:
0.53

DETAILS

ALA4466481

Name:
3-(8-amino-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)piperidine-2,6-dione

Mol. Formula:
C12H11N5O3

M.W.:
273.25

Type:
Unknown

AlogP:
-0.65

Polar Surface Area:
119.97

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
1

Passes Ro3:
N

QED Weighted:
0.53

DETAILS

CRBN-6-5-5-VHL

Name:
(2S,4R)-1-((2S)-2-(5-(5-(6-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolinShow More⌵

Mol. Formula:
C51H69N7O10S

M.W.:
972.22

3 unique targets

Type:
Unknown

AlogP:
5.67

Polar Surface Area:
225.67

HBA:
13

HBD:
5

#RO5 Violations:
3

#Rotatable Bonds:
26

Passes Ro3:
N

QED Weighted:
0.05

DETAILS

ALA4453912

Name:
3-(7-amino-4-oxobenzo[d][1,2,3]triazin-3(4H)-yl)piperidine-2,6-dione

Mol. Formula:
C12H11N5O3

M.W.:
273.25

Type:
Unknown

AlogP:
-0.65

Polar Surface Area:
119.97

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
1

Passes Ro3:
N

QED Weighted:
0.53

DETAILS

ALA4453498

Name:
2-Adamantan-1-yl-N-[2-(2-{2-[2-(2,6-dioxo-piperidin-3-yl)-1,3-dioxo-2,3-dihShow More⌵

Mol. Formula:
C31H40N4O7

M.W.:
580.68

5 activity values

Type:
Unknown

AlogP:
2.26

Polar Surface Area:
143.14

HBA:
8

HBD:
3

#RO5 Violations:
1

#Rotatable Bonds:
13

Passes Ro3:
N

QED Weighted:
0.24

DETAILS

ALA4440626

Name:
tert-butyl 4-[3-[4-[3-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-ylShow More⌵

Mol. Formula:
C31H44N4O9

M.W.:
616.71

1 activity values

Type:
Unknown

AlogP:
2.33

Polar Surface Area:
169.44

HBA:
10

HBD:
3

#RO5 Violations:
1

#Rotatable Bonds:
18

Passes Ro3:
N

QED Weighted:
0.13

DETAILS

ALA4440555

Name:
2-Adamantan-1-yl-N-[3-(2-{3-[2-(2,6-dioxo-piperidin-3-yl)-1,3-dioxo-2,3-dihShow More⌵

Mol. Formula:
C33H44N4O7

M.W.:
608.74

Type:
Unknown

AlogP:
3.04

Polar Surface Area:
143.14

HBA:
8

HBD:
3

#RO5 Violations:
1

#Rotatable Bonds:
15

Passes Ro3:
N

QED Weighted:
0.20

DETAILS

ALA4435938

Name:
(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[4-[3-[4-[3-[[2-(2,6-dioShow More⌵

Mol. Formula:
C54H84N10O14S

M.W.:
1129.39

Type:
Unknown

AlogP:
---

Polar Surface Area:
---

HBA:
---

HBD:
---

#RO5 Violations:
na

#Rotatable Bonds:
---

Passes Ro3:
---

QED Weighted:
---

DETAILS

Homo-PROTAC cereblon degrader 1

Name:
4,4'-(2,2'-(ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(azanediyl)bis(Show More⌵

Mol. Formula:
C32H32N6O10

M.W.:
660.64

23 activity values