Compounds

ALA5272487

Name:
morpholino(3-((5-(3-(trifluoromethyl)benzyl)-1H-pyrazolo[3,4-b]pyridin-3-ylShow More⌵

Mol. Formula:
C25H22F3N5O2

M.W.:
481.48

Type:
---

AlogP:
4.78

Polar Surface Area:
83.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.43

DETAILS

ALA5271878

Name:
(3-((5-(4-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)amino)phenyl)(morphoShow More⌵

Mol. Formula:
C24H22FN5O2

M.W.:
431.47

Type:
---

AlogP:
3.90

Polar Surface Area:
83.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.50

DETAILS

ALA5271403

Name:
5-((3-fluorobenzyl)amino)-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimiShow More⌵

Mol. Formula:
C19H20FN5O2

M.W.:
369.40

Type:
---

AlogP:
2.39

Polar Surface Area:
80.55

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.72

DETAILS

ALA5271251

Name:
5-((1-(3-fluorophenyl)ethyl)amino)-N-(1-methylpiperidin-4-yl)pyrazolo[1,5-aShow More⌵

Mol. Formula:
C21H25FN6O

M.W.:
396.47

Type:
---

AlogP:
2.87

Polar Surface Area:
74.56

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.69

DETAILS

ALA5270643

Name:
(3-(5-(2,5-difluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)phenyl)(4-methylpShow More⌵

Mol. Formula:
C25H23F2N5O

M.W.:
447.49

Type:
---

AlogP:
3.88

Polar Surface Area:
65.12

HBA:
4

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.52

DETAILS

ALA5270347

Name:
(3-((5-(2,4-difluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)amino)phenyl)(moShow More⌵

Mol. Formula:
C24H21F2N5O2

M.W.:
449.46

Type:
---

AlogP:
4.04

Polar Surface Area:
83.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.48

DETAILS

ALA5270081

Name:
4-((5-(2,5-difluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)amino)-N-(piperidShow More⌵

Mol. Formula:
C25H24F2N6O

M.W.:
462.50

Type:
---

AlogP:
4.05

Polar Surface Area:
94.73

HBA:
5

HBD:
4

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.35

DETAILS

ALA5268087

Name:
6-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(2-fluoroethyl)imiShow More⌵

Mol. Formula:
C19H18F3N5O

M.W.:
389.38

Type:
---

AlogP:
2.86

Polar Surface Area:
62.53

HBA:
5

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.73

DETAILS

ALA5282675

Name:
5-((3-fluorobenzyl)(methyl)amino)-N-((1r,4r)-4-hydroxycyclohexyl)pyrazolo[1Show More⌵

Mol. Formula:
C21H24FN5O2

M.W.:
397.45

Type:
---

AlogP:
2.54

Polar Surface Area:
82.76

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.69

DETAILS

ALA5282310

Name:
(3-((5-benzyl-1H-pyrazolo[3,4-b]pyridin-3-yl)amino)phenyl)(morpholino)methaShow More⌵

Mol. Formula:
C24H23N5O2

M.W.:
413.48

Type:
---

AlogP:
3.76

Polar Surface Area:
83.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.52

DETAILS

ALA5282186

Name:
(4-(5-(2,5-difluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)phenyl)(4-hydroxyShow More⌵

Mol. Formula:
C25H22F2N4O2

M.W.:
448.47

Type:
---

AlogP:
4.09

Polar Surface Area:
82.11

HBA:
4

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.49

DETAILS

ALA5281917

Name:
(3-((5-(2,5-difluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)amino)phenyl)(4-Show More⌵

Mol. Formula:
C25H24F2N6O

M.W.:
462.50

Type:
---

AlogP:
3.96

Polar Surface Area:
77.15

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.47

DETAILS

ALA5281780

Name:
(3-(5-(2,5-difluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)phenyl)(piperazinShow More⌵

Mol. Formula:
C24H21F2N5O

M.W.:
433.46

Type:
---

AlogP:
3.54

Polar Surface Area:
73.91

HBA:
4

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.52

DETAILS

ALA5281079

Name:
(4-((5-(2,5-difluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)amino)phenyl)(moShow More⌵

Mol. Formula:
C24H21F2N5O2

M.W.:
449.46

Type:
---

AlogP:
4.04

Polar Surface Area:
83.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.48

DETAILS

ALA5280968

Name:
(4-((5-(2,5-difluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)amino)phenyl)(3-Show More⌵

Mol. Formula:
C25H23F2N5O2

M.W.:
463.49

Type:
---

AlogP:
4.17

Polar Surface Area:
94.14

HBA:
5

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.41

DETAILS

ALA5280856

Name:
(3-((5-(2,5-difluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)amino)phenyl)(3-Show More⌵

Mol. Formula:
C25H23F2N5O2

M.W.:
463.49

Type:
---

AlogP:
4.17

Polar Surface Area:
94.14

HBA:
5

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.41

DETAILS

ALA5279655

Name:
(3-((5-(3-bromobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)amino)phenyl)(morpholShow More⌵

Mol. Formula:
C24H22BrN5O2

M.W.:
492.38

Type:
---

AlogP:
4.53

Polar Surface Area:
83.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.43

DETAILS

ALA5279643

Name:
(3-((5-(3,5-difluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)amino)phenyl)(moShow More⌵

Mol. Formula:
C24H21F2N5O2

M.W.:
449.46

Type:
---

AlogP:
4.04

Polar Surface Area:
83.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.48

DETAILS

ALA5278233

Name:
(3-((5-(3-chlorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)amino)phenyl)(morphoShow More⌵

Mol. Formula:
C24H22ClN5O2

M.W.:
447.93

Type:
---

AlogP:
4.42

Polar Surface Area:
83.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.47

DETAILS

ALA5277192

Name:
(3-((5-(3,4-difluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)amino)phenyl)(moShow More⌵

Mol. Formula:
C24H21F2N5O2

M.W.:
449.46

Type:
---

AlogP:
4.04

Polar Surface Area:
83.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.48

DETAILS