Compounds

Type:
---

AlogP:
3.11

Polar Surface Area:
121.89

HBA:
7

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.59

DETAILS

ALA5202851

Name:
2-methoxy-2-methyl-N-[[6-methyl-5-[[2-(6-methyl-3-pyridyl)-4-pyridyl]oxy]-2Show More⌵

Mol. Formula:
C23H25N5O4

M.W.:
435.48

Type:
---

AlogP:
4.02

Polar Surface Area:
115.33

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.60

DETAILS

ALA5200885

Name:
2-(cyclopropylamino)-5-(6-methyl-5-(2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yShow More⌵

Mol. Formula:
C22H21N7O2

M.W.:
415.46

9 activity values

Type:
---

AlogP:
3.30

Polar Surface Area:
110.61

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.50

DETAILS

ALA5199944

Name:
2-(ethylamino)-5-(6-methyl-5-(2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)pShow More⌵

Mol. Formula:
C21H21N7O2

M.W.:
403.45

Type:
---

AlogP:
3.16

Polar Surface Area:
110.61

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.51

DETAILS

ALA5198500

Name:
4-(6-(2-(isopropylamino)-6-oxo-1,6-dihydropyrimidin-5-yl)pyridin-3-yloxy)-NShow More⌵

Mol. Formula:
C19H20N6O3

M.W.:
380.41

Type:
---

AlogP:
2.20

Polar Surface Area:
121.89

HBA:
7

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.60

DETAILS

ALA5197530

Name:
2-(4-fluorophenyl)-N-[[6-methyl-5-[[2-(1-methylpyrazol-4-yl)-4-pyridyl]oxy]Show More⌵

Mol. Formula:
C24H21FN6O3

M.W.:
460.47

Type:
---

AlogP:
4.01

Polar Surface Area:
111.03

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.45

DETAILS

ALA5197168

Name:
4-methyl-N-[[6-methyl-5-[[2-(1-methylpyrazol-4-yl)-4-pyridyl]oxy]-2-pyridylShow More⌵

Mol. Formula:
C23H26N6O4

M.W.:
450.50

9 activity values

Type:
---

AlogP:
3.44

Polar Surface Area:
120.26

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.61

DETAILS

ALA5197156

Name:
2-(ethylamino)-5-(5-(2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)pyridin-2-Show More⌵

Mol. Formula:
C20H19N7O2

M.W.:
389.42

Type:
---

AlogP:
2.85

Polar Surface Area:
110.61

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.52

DETAILS

ALA5195204

Name:
2,2-dimethyl-N-[[6-methyl-5-[[2-(1-methylpyrazol-4-yl)-4-pyridyl]oxy]-2-pyrShow More⌵

Mol. Formula:
C21H24N6O3

M.W.:
408.46

36 activity values

16 unique targets

Type:
---

AlogP:
3.67

Polar Surface Area:
111.03

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.68

DETAILS

ALA5194023

Name:
2-methyl-N-[[6-methyl-5-[[2-(1-methylpyrazol-4-yl)-4-pyridyl]oxy]-2-pyridylShow More⌵

Mol. Formula:
C20H22N6O3

M.W.:
394.44

Type:
---

AlogP:
3.28

Polar Surface Area:
111.03

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.69

DETAILS

ALA5193071

Name:
2-(isopropylamino)-5-(6-methyl-5-(2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloShow More⌵

Mol. Formula:
C22H23N7O2

M.W.:
417.47

28 activity values

Type:
---

AlogP:
3.55

Polar Surface Area:
110.61

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.49

DETAILS

ALA5192630

Name:
2-(cyclopentylamino)-5-(6-methyl-5-(2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yShow More⌵

Mol. Formula:
C24H25N7O2

M.W.:
443.51

Type:
---

AlogP:
4.08

Polar Surface Area:
110.61

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.46

DETAILS

ALA5192531

Name:
N-[[6-ethyl-5-[[2-(1-methylpyrazol-4-yl)-4-pyridyl]oxy]-2-pyridyl]carbamoylShow More⌵

Mol. Formula:
C22H26N6O3

M.W.:
422.49

Type:
---

AlogP:
3.93

Polar Surface Area:
111.03

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.64

DETAILS

ALA5191854

Name:
2-methoxy-N-[[6-methyl-5-[[2-(1-methylpyrazol-4-yl)-4-pyridyl]oxy]-2-pyridyShow More⌵

Mol. Formula:
C19H20N6O4

M.W.:
396.41

Type:
---

AlogP:
2.27

Polar Surface Area:
120.26

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.66

DETAILS

ALA5191635

Name:
N-[[6-methyl-5-[[2-(1-methylpyrazol-4-yl)-4-pyridyl]oxy]-2-pyridyl]carbamoyShow More⌵

Mol. Formula:
C21H22N6O4

M.W.:
422.45

Type:
---

AlogP:
2.66

Polar Surface Area:
120.26

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.65

DETAILS

ALA5190410

Name:
5-(6-methyl-5-(2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)pyridin-2-yl)-2-Show More⌵

Mol. Formula:
C24H25N7O3

M.W.:
459.51

Type:
---

AlogP:
3.32

Polar Surface Area:
119.84

HBA:
9

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.45

DETAILS

ALA5190097

Name:
N-[[3-fluoro-4-[[2-(1-methylpyrazol-4-yl)-4-pyridyl]oxy]phenyl]carbamoyl]-2Show More⌵

Mol. Formula:
C24H19F2N5O3

M.W.:
463.44

Type:
---

AlogP:
4.44

Polar Surface Area:
98.14

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.44

DETAILS

ALA5189828

Name:
5-(6-methyl-5-(2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)pyridin-2-yl)-2-Show More⌵

Mol. Formula:
C24H25N7O2

M.W.:
443.51

Type:
---

AlogP:
3.72

Polar Surface Area:
101.82

HBA:
8

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.50

DETAILS

ALA5189742

Name:
5-(5-(2-(1-ethyl-1H-pyrazol-4-yl)pyridin-4-yloxy)-6-methylpyridin-2-yl)-2-(Show More⌵

Mol. Formula:
C23H25N7O2

M.W.:
431.50