Compounds

ALA5272546

Name:
2-chloro-N-(3-((6-((4-methoxybenzyl)amino)pyrimidin-4-yl)oxy)phenyl)acetamiShow More⌵

Mol. Formula:
C20H19ClN4O3

M.W.:
398.85

Type:
---

AlogP:
4.07

Polar Surface Area:
85.37

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
8

Passes Ro3:
N

QED Weighted:
0.56

DETAILS

ALA5271906

Name:
2-chloro-N-(3-((6-(cyclopentylamino)pyrimidin-4-yl)oxy)phenyl)acetamide

Mol. Formula:
C17H19ClN4O2

M.W.:
346.82

Type:
---

AlogP:
3.80

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.78

DETAILS

ALA5271519

Name:
2-chloro-N-(3-((6-((4-methylbenzyl)amino)pyrimidin-4-yl)oxy)phenyl)acetamidShow More⌵

Mol. Formula:
C20H19ClN4O2

M.W.:
382.85

Type:
---

AlogP:
4.37

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.59

DETAILS

ALA5271442

Name:
2-chloro-N-(3-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)acetamide

Mol. Formula:
C13H13ClN4O2

M.W.:
292.73

Type:
---

AlogP:
2.49

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.83

DETAILS

ALA5271334

Name:
2-chloro-N-(3-((6-((2,4-difluorobenzyl)amino)pyrimidin-4-yl)oxy)phenyl)acetShow More⌵

Mol. Formula:
C19H15ClF2N4O2

M.W.:
404.80

Type:
---

AlogP:
4.34

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.57

DETAILS

ALA5271266

Name:
N-(3-((6-(benzyl(methyl)amino)pyrimidin-4-yl)oxy)phenyl)-2-chloroacetamide

Mol. Formula:
C20H19ClN4O2

M.W.:
382.85

Type:
---

AlogP:
4.08

Polar Surface Area:
67.35

HBA:
5

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.62

DETAILS

ALA5270550

Name:
N-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)acrylamide

Mol. Formula:
C14H14N4O2

M.W.:
270.29

Type:
---

AlogP:
2.44

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.82

DETAILS

ALA5268287

Name:
2-chloro-N-(3-((6-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)oxy)phenyShow More⌵

Mol. Formula:
C17H19ClN4O3

M.W.:
362.82

Type:
---

AlogP:
3.04

Polar Surface Area:
85.37

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.77

DETAILS

ALA5282673

Name:
N-(3-((6-((2-(1H-indol-3-yl)ethyl)amino)pyrimidin-4-yl)oxy)phenyl)-2-chloroShow More⌵

Mol. Formula:
C22H20ClN5O2

M.W.:
421.89

Type:
---

AlogP:
4.58

Polar Surface Area:
91.93

HBA:
5

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
8

Passes Ro3:
N

QED Weighted:
0.36

DETAILS

ALA5281707

Name:
2-chloro-N-(3-((6-((2-(trifluoromethyl)benzyl)amino)pyrimidin-4-yl)oxy)phenShow More⌵

Mol. Formula:
C20H16ClF3N4O2

M.W.:
436.82

Type:
---

AlogP:
5.08

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
1

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.51

DETAILS

ALA5279577

Name:
2-chloro-N-(3-((6-((3,5-difluorobenzyl)amino)pyrimidin-4-yl)oxy)phenyl)acetShow More⌵

Mol. Formula:
C19H15ClF2N4O2

M.W.:
404.80

Type:
---

AlogP:
4.34

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.57

DETAILS

ALA5278028

Name:
2-chloro-N-(3-((6-((4-methoxyphenethyl)amino)pyrimidin-4-yl)oxy)phenyl)acetShow More⌵

Mol. Formula:
C21H21ClN4O3

M.W.:
412.88

Type:
---

AlogP:
4.11

Polar Surface Area:
85.37

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
9

Passes Ro3:
N

QED Weighted:
0.51

DETAILS

ALA5277855

Name:
2-chloro-N-(3-((6-((3,4-dimethoxybenzyl)amino)pyrimidin-4-yl)oxy)phenyl)aceShow More⌵

Mol. Formula:
C21H21ClN4O4

M.W.:
428.88

Type:
---

AlogP:
4.08

Polar Surface Area:
94.60

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
9

Passes Ro3:
N

QED Weighted:
0.50

DETAILS

ALA5277053

Name:
2-fluoro-N-(3-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)acetamide

Mol. Formula:
C13H13FN4O2

M.W.:
276.27

Type:
---

AlogP:
2.22

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.88

DETAILS

ALA5274709

Name:
2-chloro-N-(3-((6-((4-fluoro-3-(trifluoromethyl)benzyl)amino)pyrimidin-4-ylShow More⌵

Mol. Formula:
C20H15ClF4N4O2

M.W.:
454.81

Type:
---

AlogP:
5.22

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
1

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.38

DETAILS

ALA5274241

Name:
2-chloro-N-(3-((6-phenethylpyrimidin-4-yl)oxy)phenyl)acetamide

Mol. Formula:
C20H18ClN3O2

M.W.:
367.84

Type:
---

AlogP:
4.23

Polar Surface Area:
64.11

HBA:
4

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.63

DETAILS

ALA5273951

Name:
2-chloro-N-(3-((6-((3,4-dimethoxyphenethyl)amino)pyrimidin-4-yl)oxy)phenyl)Show More⌵

Mol. Formula:
C22H23ClN4O4

M.W.:
442.90

Type:
---

AlogP:
4.12

Polar Surface Area:
94.60

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
10

Passes Ro3:
N

QED Weighted:
0.46

DETAILS

ALA5273762

Name:
N-(3-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)acrylamide

Mol. Formula:
C14H14N4O2

M.W.:
270.29

Type:
---

AlogP:
2.44

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.82

DETAILS

ALA5273066

Name:
2-chloro-N-(3-((6-((4-(trifluoromethyl)benzyl)amino)pyrimidin-4-yl)oxy)phenShow More⌵

Mol. Formula:
C20H16ClF3N4O2

M.W.:
436.82

Type:
---

AlogP:
5.08

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
1

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.51

DETAILS

ALA5286411

Name:
(E/Z)-N-(3-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)but-2-enamide

Mol. Formula:
C15H16N4O2

M.W.:
284.32

Type:
---

AlogP:
2.83

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.83

DETAILS