Compounds

ALA5267684

Name:
2-chloro-N-(3-((6-((2,3,6-trifluorobenzyl)amino)pyrimidin-4-yl)oxy)phenyl)aShow More⌵

Mol. Formula:
C19H14ClF3N4O2

M.W.:
422.79

Type:
---

AlogP:
4.48

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.43

DETAILS

ALA5267499

Name:
2-chloro-N-(3-((6-((4-chlorophenethyl)amino)pyrimidin-4-yl)oxy)phenyl)acetaShow More⌵

Mol. Formula:
C20H18Cl2N4O2

M.W.:
417.30

Type:
---

AlogP:
4.75

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
8

Passes Ro3:
N

QED Weighted:
0.52

DETAILS

ALA5266940

Name:
2-chloro-N-(3-((6-((2-methoxybenzyl)amino)pyrimidin-4-yl)oxy)phenyl)acetamiShow More⌵

Mol. Formula:
C20H19ClN4O3

M.W.:
398.85

Type:
---

AlogP:
4.07

Polar Surface Area:
85.37

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
8

Passes Ro3:
N

QED Weighted:
0.56

DETAILS

ALA5266650

Name:
N-(3-((6-((2-(benzo[d][1,3]dioxol-5-yl)ethyl)amino)pyrimidin-4-yl)oxy)phenyShow More⌵

Mol. Formula:
C21H19ClN4O4

M.W.:
426.86

Type:
---

AlogP:
3.83

Polar Surface Area:
94.60

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
8

Passes Ro3:
N

QED Weighted:
0.53

DETAILS

ALA5266401

Name:
2-chloro-N-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)acetamide

Mol. Formula:
C13H13ClN4O2

M.W.:
292.73

Type:
---

AlogP:
2.49

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.83

DETAILS

ALA5282673

Name:
N-(3-((6-((2-(1H-indol-3-yl)ethyl)amino)pyrimidin-4-yl)oxy)phenyl)-2-chloroShow More⌵

Mol. Formula:
C22H20ClN5O2

M.W.:
421.89

Type:
---

AlogP:
4.58

Polar Surface Area:
91.93

HBA:
5

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
8

Passes Ro3:
N

QED Weighted:
0.36

DETAILS

ALA5281707

Name:
2-chloro-N-(3-((6-((2-(trifluoromethyl)benzyl)amino)pyrimidin-4-yl)oxy)phenShow More⌵

Mol. Formula:
C20H16ClF3N4O2

M.W.:
436.82

Type:
---

AlogP:
5.08

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
1

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.51

DETAILS

ALA5279577

Name:
2-chloro-N-(3-((6-((3,5-difluorobenzyl)amino)pyrimidin-4-yl)oxy)phenyl)acetShow More⌵

Mol. Formula:
C19H15ClF2N4O2

M.W.:
404.80

Type:
---

AlogP:
4.34

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.57

DETAILS

ALA5278028

Name:
2-chloro-N-(3-((6-((4-methoxyphenethyl)amino)pyrimidin-4-yl)oxy)phenyl)acetShow More⌵

Mol. Formula:
C21H21ClN4O3

M.W.:
412.88

Type:
---

AlogP:
4.11

Polar Surface Area:
85.37

HBA:
6

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
9

Passes Ro3:
N

QED Weighted:
0.51

DETAILS

ALA5277855

Name:
2-chloro-N-(3-((6-((3,4-dimethoxybenzyl)amino)pyrimidin-4-yl)oxy)phenyl)aceShow More⌵

Mol. Formula:
C21H21ClN4O4

M.W.:
428.88

Type:
---

AlogP:
4.08

Polar Surface Area:
94.60

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
9

Passes Ro3:
N

QED Weighted:
0.50

DETAILS

ALA5277053

Name:
2-fluoro-N-(3-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)acetamide

Mol. Formula:
C13H13FN4O2

M.W.:
276.27

Type:
---

AlogP:
2.22

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.88

DETAILS

ALA5274709

Name:
2-chloro-N-(3-((6-((4-fluoro-3-(trifluoromethyl)benzyl)amino)pyrimidin-4-ylShow More⌵

Mol. Formula:
C20H15ClF4N4O2

M.W.:
454.81

Type:
---

AlogP:
5.22

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
1

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.38

DETAILS

ALA5274241

Name:
2-chloro-N-(3-((6-phenethylpyrimidin-4-yl)oxy)phenyl)acetamide

Mol. Formula:
C20H18ClN3O2

M.W.:
367.84

Type:
---

AlogP:
4.23

Polar Surface Area:
64.11

HBA:
4

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.63

DETAILS

ALA5273951

Name:
2-chloro-N-(3-((6-((3,4-dimethoxyphenethyl)amino)pyrimidin-4-yl)oxy)phenyl)Show More⌵

Mol. Formula:
C22H23ClN4O4

M.W.:
442.90

Type:
---

AlogP:
4.12

Polar Surface Area:
94.60

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
10

Passes Ro3:
N

QED Weighted:
0.46

DETAILS

ALA5273762

Name:
N-(3-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)acrylamide

Mol. Formula:
C14H14N4O2

M.W.:
270.29

Type:
---

AlogP:
2.44

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.82

DETAILS

ALA5273066

Name:
2-chloro-N-(3-((6-((4-(trifluoromethyl)benzyl)amino)pyrimidin-4-yl)oxy)phenShow More⌵

Mol. Formula:
C20H16ClF3N4O2

M.W.:
436.82

Type:
---

AlogP:
5.08

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
1

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.51

DETAILS

ALA5291268

Name:
3-chloro-2,2-dimethyl-N-(3-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)propaShow More⌵

Mol. Formula:
C16H19ClN4O2

M.W.:
334.81

Type:
---

AlogP:
3.51

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.79

DETAILS

ALA5287907

Name:
2-chloro-N-(3-((6-morpholinopyrimidin-4-yl)oxy)phenyl)acetamide

Mol. Formula:
C16H17ClN4O3

M.W.:
348.79

Type:
---

AlogP:
2.28

Polar Surface Area:
76.58

HBA:
6

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.84

DETAILS

ALA5286411

Name:
(E/Z)-N-(3-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)but-2-enamide

Mol. Formula:
C15H16N4O2

M.W.:
284.32

Type:
---

AlogP:
2.83

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.83

DETAILS

ALA5284723

Name:
N-(3-((6-(benzylamino)pyrimidin-4-yl)oxy)phenyl)-2-chloroacetamide

Mol. Formula:
C19H17ClN4O2

M.W.:
368.82

Type:
---

AlogP:
4.06

Polar Surface Area:
76.14

HBA:
5

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.61

DETAILS