Compounds

ALA5272567

Name:
1-[4-[4-[(6-methyl-4-tetrahydropyran-4-yloxy-pyrido[3,2-d]pyrimidin-2-yl)amShow More⌵

Mol. Formula:
C23H29N7O3

M.W.:
451.53

Type:
---

AlogP:
3.01

Polar Surface Area:
107.29

HBA:
9

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.63

DETAILS

ALA5272466

Name:
2-[2-[(1-methylpyrazol-4-yl)amino]-4-[[(3S)-tetrahydrofuran-3-yl]amino]pyriShow More⌵

Mol. Formula:
C17H18N8O

M.W.:
350.39

Type:
---

AlogP:
1.77

Polar Surface Area:
113.57

HBA:
9

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.72

DETAILS

ALA5271317

Name:
N-(3-Carbamoyl-1-(oxan-4-yl)-1H-pyrazol-4-yl)-2-(2-ethylpyridin-4-yl)-1,3-oShow More⌵

Mol. Formula:
C20H22N6O4

M.W.:
410.43

Type:
---

AlogP:
2.20

Polar Surface Area:
138.16

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.64

DETAILS

ALA5271049

Name:
2-[2-[(1-methylpyrazol-4-yl)amino]-4-[[(3R)-tetrahydrofuran-3-yl]amino]pyriShow More⌵

Mol. Formula:
C17H18N8O

M.W.:
350.39

Type:
---

AlogP:
1.77

Polar Surface Area:
113.57

HBA:
9

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.72

DETAILS

ALA5270903

Name:
7-fluoro-N-[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]-4-(1-methyShow More⌵

Mol. Formula:
C26H28FN9O

M.W.:
501.57

Type:
---

AlogP:
4.07

Polar Surface Area:
106.77

HBA:
10

HBD:
1

#RO5 Violations:
1

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.42

DETAILS

ALA5270577

Name:
4-(1-methylcyclopropoxy)-6-(1-methylimidazol-4-yl)-N-[1-(1-methyl-4-piperidShow More⌵

Mol. Formula:
C24H29N9O

M.W.:
459.56

Type:
---

AlogP:
3.56

Polar Surface Area:
98.81

HBA:
10

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.47

DETAILS

ALA5270356

Name:
6-(2,4-dimethylpyrimidin-5-yl)-4-(1-methylcyclopropoxy)-N-[1-(1-methyl-4-piShow More⌵

Mol. Formula:
C26H31N9O

M.W.:
485.60

Type:
---

AlogP:
4.24

Polar Surface Area:
106.77

HBA:
10

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.43

DETAILS

ALA5270136

Name:
4-(1-methylcyclopropoxy)-N-[1-(1-methyl-4-piperidyl)pyrazol-4-yl]-6-(4-methShow More⌵

Mol. Formula:
C25H29N9O

M.W.:
471.57

Type:
---

AlogP:
3.93

Polar Surface Area:
106.77

HBA:
10

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.45

DETAILS

ALA5270030

Name:
7-fluoro-N2-[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]-N4-(1-metShow More⌵

Mol. Formula:
C26H29FN10

M.W.:
500.59

Type:
---

AlogP:
4.10

Polar Surface Area:
109.57

HBA:
10

HBD:
2

#RO5 Violations:
1

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.40

DETAILS

ALA5269297

Name:
4-(1-methylcyclopropoxy)-N-[1-(1-methyl-4-piperidyl)pyrazol-4-yl]-6-(1-methShow More⌵

Mol. Formula:
C23H28N10O

M.W.:
460.55

Type:
---

AlogP:
2.96

Polar Surface Area:
111.70

HBA:
11

HBD:
1

#RO5 Violations:
1

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.46

DETAILS

ALA5268077

Name:
N-(3-Carbamoyl-1-(oxan-4-yl)-1H-pyrazol-4-yl)-2-(3-fluoropyridin-4-yl)-1,3-Show More⌵

Mol. Formula:
C18H17FN6O4

M.W.:
400.37

Type:
---

AlogP:
1.77

Polar Surface Area:
138.16

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.67

DETAILS

ALA5267973

Name:
N-(3-Carbamoyl-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)-1,3-oxazole-4-carbShow More⌵

Mol. Formula:
C14H12N6O3

M.W.:
312.29

Type:
---

AlogP:
1.12

Polar Surface Area:
139.79

HBA:
6

HBD:
3

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.66

DETAILS

ALA5282374

Name:
N-(3-Carbamoyl-1-(oxan-4-yl)-1H-pyrazol-4-yl)-1-(2-methylpyridin-4-yl)-1H-pShow More⌵

Mol. Formula:
C19H21N7O3

M.W.:
395.42

Type:
---

AlogP:
1.47

Polar Surface Area:
129.95

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.67

DETAILS

ALA5281809

Name:
7-fluoro-N-[1-[(1R,4R,5R)-2-methyl-2-azabicyclo[2.2.1]heptan-5-yl]pyrazol-4Show More⌵

Mol. Formula:
C26H28FN9O

M.W.:
501.57

Type:
---

AlogP:
4.07

Polar Surface Area:
106.77

HBA:
10

HBD:
1

#RO5 Violations:
1

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.42

DETAILS

ALA5281595

Name:
4-(1-methylcyclopropoxy)-N-[1-(1-methyl-4-piperidyl)pyrazol-4-yl]-6-pyridazShow More⌵

Mol. Formula:
C24H27N9O

M.W.:
457.54

Type:
---

AlogP:
3.62

Polar Surface Area:
106.77

HBA:
10

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.46

DETAILS

ALA5281524

Name:
6-cyclopropyl-4-(1-methylcyclopropoxy)-N-[1-(1-methyl-4-piperidyl)pyrazol-4Show More⌵

Mol. Formula:
C23H29N7O

M.W.:
419.53

Type:
---

AlogP:
4.04

Polar Surface Area:
80.99

HBA:
8

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.65

DETAILS

ALA5280941

Name:
N-(1-Butyl-3-carbamoyl-1H-pyrazol-4-yl)-2-(2-methylpyridin-4-yl)-1,3-oxazolShow More⌵

Mol. Formula:
C18H21ClN6O3

M.W.:
404.86

Type:
---

AlogP:
2.39

Polar Surface Area:
128.93

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
7

Passes Ro3:
N

QED Weighted:
0.66

DETAILS

ALA5278799

Name:
N-(3-Carbamoyl-1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl)-2-(2-methylpyridShow More⌵

Mol. Formula:
C20H25Cl2N7O3

M.W.:
482.37

Type:
---

AlogP:
1.86

Polar Surface Area:
132.17

HBA:
8

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.66

DETAILS

ALA5278052

Name:
N-(3-Carbamoyl-1-ethyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-1,3-thiazole-4-carShow More⌵

Mol. Formula:
C15H15ClN6O2S

M.W.:
378.85

Type:
---

AlogP:
1.77

Polar Surface Area:
115.79

HBA:
7

HBD:
2

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.73

DETAILS

ALA5277765

Name:
2-((2-aminoethyl)amino)-N-(3-carbamoyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl)pShow More⌵

Mol. Formula:
C17H20F3N9O5

M.W.:
487.40

Type:
---

AlogP:
-1.36

Polar Surface Area:
178.48

HBA:
10

HBD:
5

#RO5 Violations:
---

#Rotatable Bonds:
8

Passes Ro3:
N

QED Weighted:
0.32

DETAILS