Compounds

Type:
Small molecule

AlogP:
3.98

Polar Surface Area:
89.25

HBA:
6

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.48

DETAILS

ALA3729345

Name:
2,6-dimethyl-4-[3-(6-quinolyl)imidazo[1,2-a]pyrazi
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Mol. Formula:
C23H18N4O

M.W.:
366.42

Type:
Small molecule

AlogP:
4.93

Polar Surface Area:
63.31

HBA:
5

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
2

Passes Ro3:
N

QED Weighted:
0.48

DETAILS

ALA3732055

Name:
2-methoxy-4-[3-(6-quinolyl)imidazo[1,2-a]pyrazin-6
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Mol. Formula:
C22H16N4O2

M.W.:
368.40

Type:
Small molecule

AlogP:
4.33

Polar Surface Area:
72.54

HBA:
6

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.51

DETAILS

ALA3729479

Name:
6-[6-(3,4,5-trimethoxyphenyl)imidazo[1,2-a]pyrazin
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Mol. Formula:
C24H20N4O3

M.W.:
412.45

Type:
Small molecule

AlogP:
4.64

Polar Surface Area:
70.77

HBA:
7

HBD:
---

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.42

DETAILS

ALA3728390

Name:
6-(benzothiophen-2-yl)-3-(1-methylpyrazol-4-yl)imi
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Mol. Formula:
C18H13N5S

M.W.:
331.40

Type:
Small molecule

AlogP:
4.01

Polar Surface Area:
48.01

HBA:
6

HBD:
---

#RO5 Violations:
---

#Rotatable Bonds:
2

Passes Ro3:
N

QED Weighted:
0.49

DETAILS

ALA3729425

Name:
3-(1-methylpyrazol-4-yl)-6-(4-pyridyl)imidazo[1,2-
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Mol. Formula:
C15H12N6

M.W.:
276.30

Type:
Small molecule

AlogP:
2.19

Polar Surface Area:
60.90

HBA:
6

HBD:
---

#RO5 Violations:
---

#Rotatable Bonds:
2

Passes Ro3:
N

QED Weighted:
0.56

DETAILS

ALA3730749

Name:
3-(3,5-dimethoxyphenyl)-6-(3-isopropoxyphenyl)imid
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Mol. Formula:
C23H23N3O3

M.W.:
389.46

Type:
Small molecule

AlogP:
4.87

Polar Surface Area:
57.88

HBA:
6

HBD:
---

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.47

DETAILS

ALA3732997

Name:
2-[3-(3,5-dimethoxyphenyl)imidazo[1,2-a]pyrazin-6-
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Mol. Formula:
C22H22N4O2

M.W.:
374.44

Type:
Small molecule

AlogP:
4.15

Polar Surface Area:
51.89

HBA:
6

HBD:
---

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.53

DETAILS

ALA3730393

Name:
N-cyclopropyl-4-[6-[4-(4-isopropylpiperazin-1-yl)p
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Mol. Formula:
C29H32N6O

M.W.:
480.62

Type:
Small molecule

AlogP:
4.49

Polar Surface Area:
65.77

HBA:
6

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
6

Passes Ro3:
N

QED Weighted:
0.44

DETAILS

ALA3728418

Name:
4-[6-(5-acetyl-2-thienyl)imidazo[1,2-a]pyrazin-3-y
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Mol. Formula:
C22H18N4O2S

M.W.:
402.48

Type:
Small molecule

AlogP:
4.22

Polar Surface Area:
76.36

HBA:
6

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.51

DETAILS

ALA3730806

Name:
N,N-dimethyl-4-[6-(1-methylindol-5-yl)imidazo[1,2-
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Mol. Formula:
C24H21N5O

M.W.:
395.47

Type:
Small molecule

AlogP:
4.26

Polar Surface Area:
55.43

HBA:
5

HBD:
---

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.46

DETAILS

ALA3728063

Name:
4-[6-(3-acetamidophenyl)imidazo[1,2-a]pyrazin-3-yl
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Mol. Formula:
C23H21N5O2

M.W.:
399.45

Type:
Small molecule

AlogP:
3.72

Polar Surface Area:
79.60

HBA:
5

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.57

DETAILS

ALA3730995

Name:
N,N-dimethyl-4-[6-(3-thienyl)imidazo[1,2-a]pyrazin
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Mol. Formula:
C19H16N4OS

M.W.:
348.43

Type:
Small molecule

AlogP:
3.83

Polar Surface Area:
50.50

HBA:
5

HBD:
---

#RO5 Violations:
---

#Rotatable Bonds:
3

Passes Ro3:
N

QED Weighted:
0.57

DETAILS

ALA3730520

Name:
N,N-dimethyl-4-[6-(2-phenoxyphenyl)imidazo[1,2-a]p
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Mol. Formula:
C27H22N4O2

M.W.:
434.50

Type:
Small molecule

AlogP:
5.56

Polar Surface Area:
59.73

HBA:
5

HBD:
---

#RO5 Violations:
1

#Rotatable Bonds:
5

Passes Ro3:
N

QED Weighted:
0.36

DETAILS

ALA3732464

Name:
N,N-dimethyl-4-[6-[6-(4-methylpiperazin-1-yl)-3-py
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Mol. Formula:
C25H27N7O

M.W.:
441.54

Type:
Small molecule

AlogP:
2.91

Polar Surface Area:
69.87

HBA:
7

HBD:
---

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.49

DETAILS

ALA3732544

Name:
6-(3-isopropoxyphenyl)-3-(2-thienyl)imidazo[1,2-a]
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Mol. Formula:
C19H17N3OS

M.W.:
335.43

Type:
Small molecule

AlogP:
4.91

Polar Surface Area:
39.42

HBA:
5

HBD:
---

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.53

DETAILS

ALA3729965

Name:
5-[3-(2-thienyl)imidazo[1,2-a]pyrazin-6-yl]pyridin
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Mol. Formula:
C15H11N5S

M.W.:
293.36

Type:
Small molecule

AlogP:
3.10

Polar Surface Area:
69.10

HBA:
6

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
2

Passes Ro3:
N

QED Weighted:
0.62

DETAILS

ALA3729206

Name:
6-(3,5-dimethoxyphenyl)-3-(2-thienyl)imidazo[1,2-a
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Mol. Formula:
C18H15N3O2S

M.W.:
337.40

Type:
Small molecule

AlogP:
4.14

Polar Surface Area:
48.65

HBA:
6

HBD:
---

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.56

DETAILS

ALA3727952

Name:
N-[3-[3-(2-thienyl)imidazo[1,2-a]pyrazin-6-yl]phen
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Mol. Formula:
C17H14N4O2S2

M.W.:
370.46

Type:
Small molecule

AlogP:
3.50

Polar Surface Area:
76.36

HBA:
6

HBD:
1

#RO5 Violations:
---

#Rotatable Bonds:
4

Passes Ro3:
N

QED Weighted:
0.60

DETAILS

ALA3732585

Name:
3,6-bis(2-thienyl)imidazo[1,2-a]pyrazine

Mol. Formula:
C14H9N3S2

M.W.:
283.38