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DCEBIO - ≥99%(HPLC), high purity , CAS No.60563-36-2, Activator of K Ca2.2;Activator of K Ca2.3;Activator of K Ca3.1
Activates Cl- conductance and hKCa3.1 channels
Basic Description Synonyms DCEBIO|60563-36-2|5,6-Dichloro-1-ethyl-1H-benzo[d]imidazol-2(3H)-one|5,6-dichloro-3-ethyl-1H-benzimidazol-2-one|dichloro-EBIO|DC-EBIO|5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one|5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazole-2-one|CHEBI:3466 Specifications & Purity Moligand™, ≥99%(HPLC) Biochemical and Physiological Mechanisms Stimulates Cl-secretion via the activation of hKCa3.1 (IK1) potassium channels and an apical Cl-conductance carried by the CFTR channel. More potent than its analog1-EBIO. Storage Temp Room temperature Shipped In Normal Grade Moligand™ Action Type ACTIVATOR Mechanism of action Activator of K Ca2.2;Activator of K Ca2.3;Activator of K Ca3.1
Names and Identifiers Pubchem Sid 488190998 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488190998 IUPAC Name 5,6-dichloro-3-ethyl-1H-benzimidazol-2-one INCHI InChI=1S/C9H8Cl2N2O/c1-2-13-8-4-6(11)5(10)3-7(8)12-9(13)14/h3-4H,2H2,1H3,(H,12,14) InChi Key LKHRMULASXZCLG-UHFFFAOYSA-N Canonical SMILES CCN1C2=CC(=C(C=C2NC1=O)Cl)Cl Isomeric SMILES CCN1C2=CC(=C(C=C2NC1=O)Cl)Cl WGK Germany 3 Alternate CAS 60563-36-2 PubChem CID 656765 MeSH Entry Terms 5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one;DCEBIO compound Molecular Weight 231.08
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 23.11, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 23.11, Max Conc. mM: 100 Melt Point(°C) 209.5 - 210.5 °C
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3 RIDADR NONHforallmodesoftransport
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