DCLK1-IN-1 - ≥98%(HPLC), high purity , CAS No.2222635-15-4, Inhibitor of doublecortin like kinase 1;Inhibitor of doublecortin like kinase 2;Inhibitor of leucine rich repeat kinase 2;Inhibitor of mitogen-activated protein kinase 7
DCLK1-IN-1 - ≥98%(HPLC), high purity , CAS No.2222635-15-4, Inhibitor of doublecortin like kinase 1;Inhibitor of doublecortin like kinase 2;Inhibitor of leucine rich repeat kinase 2;Inhibitor of mitogen-activated protein kinase 7
Potent and selective doublecortin like kinase 1/2 (DCLK1/2) inhibitor (IC50values are DCLK1 =9.5 and 57.2 nM and DCLK2 = 31 and 103 nM in binding and kinase assay, respectively). Exhibits no significant activity against ERK5, ACK, BRD4 and LRRK2. Exhibits
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of doublecortin like kinase 1;Inhibitor of doublecortin like kinase 2;Inhibitor of leucine rich repeat kinase 2;Inhibitor of mitogen-activated protein kinase 7
Product Description
DCLK1-IN-1 is a selective, in vivo-compatible chemical probe of the doublecortin like kinase 1 (DCLK1) domain that binds to DCLK1 and DCLK2 with IC50 of 9.5 nM and 31 nM, respectively. DCLK1-IN-1 inhibits DCLK1 and DCLK2 kinases with IC50 of 57.2 nM and 103 nM in kinase assay, respectively.
1.Ferguson FM, Nabet B, Raghavan S, Liu Y, Leggett AL, Kuljanin M, Kalekar RL, Yang A, He S, Wang J et al.. (2020) Discovery of a selective inhibitor of doublecortin like kinase 1.. Nat Chem Biol, 16 (6):(635-643). [PMID:32251410]
2.Ferguson FM, Liu Y, Harshbarger W, Huang L, Wang J, Deng X, Capuzzi SJ, Muratov EN, Tropsha A, Muthuswamy S et al.. (2020) Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one Scaffold.. J Med Chem, 63 (14):(7817-7826). [PMID:32530623]
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D2227077