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DCPIB - ≥98%(HPLC), high purity , CAS No.82749-70-0

Moligand™
≥98%(HPLC)

CAS#: 82749-70-0
Formula: C₂₂H₂₈Cl₂O₄
Molecular Weight: 427.37
PubChem CID: 10071166

Item Number

D286662

Grouped product items
SKU	Size	Availability	Price
D286662-5mg	5mg	In stock	$84.90
D286662-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$140.90
D286662-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$597.90
D286662-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$759.90
D286662-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,710.90

Blocker of VRAC/ICl, swell

View related series

VRAC Channel blocker

Basic Description

Synonyms	DCPIB\|82749-70-0\|4-((2-Butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy)butanoic acid\|4-[(2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy]butanoic acid\|4-[(2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-3H-inden-5-yl)o
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Volume-regulated anion channel (VRAC) blocker (IC50~ 2μM in rat pancreaticβ-cells). Also blocks ICl,swellin various cardiovascular tissues (IC50= 4.1μM in CPAE cells). Inhibits glucose-stimulated insulin secretion in intactβ-cells via VSAC inhibition and
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™

Associated Targets

VDR Tclin Vitamin D3 receptor 0 Activities

Discover Target: VDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Discover Target: KMT2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KAT2A Tchem Histone acetyltransferase KAT2A 0 Activities

Discover Target: KAT2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TSHR Tclin Thyrotropin receptor 0 Activities

Discover Target: TSHR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RECQL Tbio ATP-dependent DNA helicase Q1 0 Activities

Discover Target: RECQL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALOX15 Tchem Arachidonate 15-lipoxygenase 0 Activities

Discover Target: ALOX15

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LTB4R2 Tchem Leukotriene B4 receptor 2 0 Activities

Discover Target: LTB4R2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSPA5 Tchem Endoplasmic reticulum chaperone BiP 0 Activities

Discover Target: HSPA5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK2 Tclin Potassium channel subfamily K member 2 0 Activities

Discover Target: KCNK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[(2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-3H-inden-5-yl)oxy]butanoic acid
INCHI	InChI=1S/C22H28Cl2O4/c1-2-3-10-22(15-7-4-5-8-15)13-14-12-16(28-11-6-9-17(25)26)19(23)20(24)18(14)21(22)27/h12,15H,2-11,13H2,1H3,(H,25,26)
InChi Key	KHKGTPJPBOQECW-UHFFFAOYSA-N
Canonical SMILES	CCCCC1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCCCC(=O)O)C3CCCC3
Isomeric SMILES	CCCCC1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCCCC(=O)O)C3CCCC3
PubChem CID	10071166
Molecular Weight	427.37

PubChem CID

10071166

CAS Registry No.

82749-70-0

ChEMBL Ligand

CHEMBL152557

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
J2115101	Certificate of Analysis	Jul 16, 2024	D286662
J2115102	Certificate of Analysis	Jul 16, 2024	D286662
J2115103	Certificate of Analysis	Jul 16, 2024	D286662
J2115104	Certificate of Analysis	Jul 16, 2024	D286662
J2115105	Certificate of Analysis	Jul 16, 2024	D286662
H2309605	Certificate of Analysis	Aug 23, 2021	D286662

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS05
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H413:May cause long lasting harmful effects to aquatic life H318:Causes serious eye damage
Precautionary Statements	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help.

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