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DDD107498 - 98%, high purity , CAS No.1469439-69-7, Plasmodium falciparum elongation factor 2

Moligand™
≥98%

CAS#: 1469439-69-7
Formula: C₂₇H₃₁FN₄O₂
Molecular Weight: 462.56
PubChem CID: 71748268

Item Number

D412165

Grouped product items
SKU	Size	Availability	Price
D412165-5mg	5mg	In stock	$236.90
D412165-10mg	10mg	In stock	$375.90
D412165-25mg	25mg	In stock	$791.90
D412165-50mg	50mg	In stock	$1,266.90
D412165-100mg	100mg	In stock	$2,280.90

Parasite Inhibitors

View related series

Plasmodium falciparum elongation factor 2

Basic Description

Synonyms	DDD107498\|1469439-69-7\|cabamiquine\|DDD498\|MMV121\|DDD-107498\|MMV-121\|6-fluoro-2-(4-(morpholinomethyl)phenyl)-N-(2-(pyrrolidin-1-yl)ethyl)quinoline-4-carboxamide\|M5717\|M-5717\|E3OC1CU1F4\|4-Quinolinecarboxamide, 6-fluoro-2-(4-(4-morpholinylmethyl)phenyl)-N-(2
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Mechanism of action	Plasmodium falciparum elongation factor 2
Product Description	Information DDD107498 DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.

Associated Targets

EEF2 Tchem Elongation factor 2 1 Activities

Discover Target: EEF2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	6-fluoro-2-[4-(morpholin-4-ylmethyl)phenyl]-N-(2-pyrrolidin-1-ylethyl)quinoline-4-carboxamide
INCHI	InChI=1S/C27H31FN4O2/c28-22-7-8-25-23(17-22)24(27(33)29-9-12-31-10-1-2-11-31)18-26(30-25)21-5-3-20(4-6-21)19-32-13-15-34-16-14-32/h3-8,17-18H,1-2,9-16,19H2,(H,29,33)
InChi Key	BENUHBSJOJMZEE-UHFFFAOYSA-N
Canonical SMILES	C1CCN(C1)CCNC(=O)C2=CC(=NC3=C2C=C(C=C3)F)C4=CC=C(C=C4)CN5CCOCC5
Isomeric SMILES	C1CCN(C1)CCNC(=O)C2=CC(=NC3=C2C=C(C=C3)F)C4=CC=C(C=C4)CN5CCOCC5
PubChem CID	71748268
Molecular Weight	462.56

PubChem CID

71748268

ChEMBL Ligand

CHEMBL4091762

CAS Registry No.

1469439-69-7

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
K2218375	Certificate of Analysis	Aug 29, 2022	D412165
K2218377	Certificate of Analysis	Aug 29, 2022	D412165
K2218410	Certificate of Analysis	Aug 29, 2022	D412165
K2218411	Certificate of Analysis	Aug 29, 2022	D412165
K2218412	Certificate of Analysis	Aug 29, 2022	D412165

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

References

1. Baragaña B, Hallyburton I, Lee MC, Norcross NR, Grimaldi R, Otto TD, Proto WR, Blagborough AM, Meister S, Wirjanata G et al.. (2015) A novel multiple-stage antimalarial agent that inhibits protein synthesis.. Nature, 522 (7556): (315-20). [PMID:26085270]
2. Rottmann M, Jonat B, Gumpp C, Dhingra SK, Giddins MJ, Yin X, Badolo L, Greco B, Fidock DA, Oeuvray C et al.. (2020) Preclinical Antimalarial Combination Study of M5717, a Plasmodium falciparum Elongation Factor 2 Inhibitor, and Pyronaridine, a Hemozoin Formation Inhibitor.. Antimicrob Agents Chemother, 64 (4): (589-97). [PMID:32041711]

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