| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| D647055-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $50.90 |
Ketones, Aldehydes, Acids
| Specifications & Purity | ≥98.0% |
|---|---|
| Storage Temp | Store at 2-8°C,Protected from light,Desiccated |
| Shipped In | Wet ice |
| Product Description | Demethylcantharidate disodium, an endogenous metabolite , induces apoptosis in hepatocellular carcinoma cells via ER stress. Demethylcantharidate disodium shows excellent anticancer activity against multiple types of cancer. In Vitro Demethylcantharidate (0-100 μM; 0, 12, 24, 48 or 72 hours) disodium inhibits HCC cell proliferation. Demethylcantharidate (0, 9, 18 or 36 µM; 24 hours) disodium dose dependently increases the levels of cleaved caspase-3, cleaved caspase-9, and Bax/Bcl-2. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HCC cell lines (SMMC-7721 and Bel-7402) Concentration: 0-100 μM Incubation Time: 0, 12, 24, 48 or 72 hours Result: Showed anti-proliferative activity in the two HCC cell lines. Cell Viability AssayCell Line: HCC cells Concentration: 0, 9, 18 or 36 µM Incubation Time: 24 hours Result: Induced apoptosis in HCC cells via the intrinsic pathway. In Vivo Demethylcantharidate disodium significantly decreases hepatocellular carcinoma tumorigenesis of SMMC-7721 cells in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid |
| Canonical SMILES | C1CC2C(C(C1O2)C(=O)O)C(=O)O.[Na+].[Na+] |
|---|---|
| Isomeric SMILES | C1CC2C(C(C1O2)C(=O)O)C(=O)O.[Na+].[Na+] |
| PubChem CID | 162368041 |
| Molecular Weight | 230.13 |
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| Solubility | H2O : 33.33 mg/mL (144.83 mM; ultrasonic and warming and heat to 60°C) DMSO : <1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble) |
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