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Demethyleneberberine - ≥98%, high purity , CAS No.25459-91-0
TNF-α Selective Inhibitors | Activators | Antagonists
Basic Description Synonyms Demethyleneberberine|25459-91-0|9,10-dimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2,3-diol|Dehydrostepholidine chloride|CHEMBL575979|NSC627882|CHEMBL379449|SCHEMBL2742479|DTXSID80180132|HY-N0592|BDBM50300549|s3299|AKOS037514619|AC-34618|NCI60 Specifications & Purity ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Information
Demethyleneberberine (DMB), a component of Cortex Phellodendri Chinensis (CPC), significantly alleviates the weight loss and diminishesmyeloperoxidase (MPO)activity, while significantly reduces the production of pro-inflammatory cytokines, such asinterleukin (IL)-6andtumor necrosis factor-α (TNF-α), and inhibits the activation ofNF-κBsignaling pathway. Demethyleneberberine (DMB) potentially ameliorates NAFLD (Non-alcoholic fatty liver disease) by activating
Targets
NF-κB ; MPO ; IL-6 ; TNF-α ; IL-1β 33791,
Names and Identifiers IUPAC Name 9,10-dimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2,3-diol INCHI InChI=1S/C19H17NO4/c1-23-18-4-3-11-7-15-13-9-17(22)16(21)8-12(13)5-6-20(15)10-14(11)19(18)24-2/h3-4,7-10,22H,5-6H2,1-2H3/p+1 InChi Key HVTCKKMWZDDWOY-UHFFFAOYSA-O Canonical SMILES COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)O)OC Isomeric SMILES COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)O)OC PubChem CID 363209 Molecular Weight 324.35
Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 3 mg/mL (9.24 mM); Sensitivity Light sensitive
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H2220065