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dequalinium , CAS No.6707-58-0, Channel blocker of CNGA1;Channel blocker of CNGA2;Channel blocker of K Ca2.1;Channel blocker of K Ca2.2;Channel blocker of K Ca2.3

  • Moligand™
Item Number
D609810
Grouped product items
SKUSizeAvailabilityPrice Qty
D609810-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,400.90
D609810-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,000.90
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View related series
CNGA1 Channel blocker CNGA2 Channel blocker KCa2.1 Channel blocker KCa2.2 Channel blocker KCa2.3 Channel blocker

Basic Description

Synonymsdequalinium|6707-58-0|Dequadin|dequaliniumchloride|Dequalinium cation|Dequavagyn|1-[10-(4-amino-2-methylquinolin-1-ium-1-yl)decyl]-2-methylquinolin-1-ium-4-amine|E7QC7V26B8|CHEBI:41872|Dekadin|Dequavet|Labosept|Oralgol|Rumilet|Sanoral|Sentril|Ivazil|Sorot
GradeMoligand™
Action TypeCHANNEL BLOCKER
Mechanism of actionChannel blocker of CNGA1;Channel blocker of CNGA2;Channel blocker of K Ca2.1;Channel blocker of K Ca2.2;Channel blocker of K Ca2.3

Product Properties

ALogP7.3

Associated Targets

CNGA1 Tchem cGMP-gated cation channel alpha-1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CNGA2 Tchem Cyclic nucleotide-gated olfactory channel 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNN1 Tchem Small conductance calcium-activated potassium channel protein 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNN3 Tchem Small conductance calcium-activated potassium channel protein 3 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNN2 Tchem Small conductance calcium-activated potassium channel protein 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 1-[10-(4-amino-2-methylquinolin-1-ium-1-yl)decyl]-2-methylquinolin-1-ium-4-amine
INCHI InChI=1S/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2
InChi Key PCSWXVJAIHCTMO-UHFFFAOYSA-P
Canonical SMILES Nc1cc(C)[n+](c2c1cccc2)CCCCCCCCCC[n+]1c(C)cc(c2c1cccc2)N
Isomeric SMILES CC1=[N+](C2=CC=CC=C2C(=C1)N)CCCCCCCCCC[N+]3=C(C=C(C4=CC=CC=C43)N)C
PubChem CID 2993
Molecular Weight 456.7

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Shah M, Haylett DG.  (2000)  The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines..  Br J Pharmacol,  129  (4): (627-30).  [PMID:10683185]
2. Strøbaek D, Jørgensen TD, Christophersen P, Ahring PK, Olesen SP.  (2000)  Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells..  Br J Pharmacol,  129  (5): (991-9).  [PMID:10696100]
3. Dreixler JC, Bian J, Cao Y, Roberts MT, Roizen JD, Houamed KM.  (2000)  Block of rat brain recombinant SK channels by tricyclic antidepressants and related compounds..  Eur J Pharmacol,  401  (1): (1-7).  [PMID:10915830]
4. Terstappen GC, Pula G, Carignani C, Chen MX, Roncarati R.  (2001)  Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines..  Neuropharmacology,  40  (6): (772-83).  [PMID:11369031]

Solution Calculators

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