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deutetrabenazine , CAS No.1392826-25-3, Inhibitor of Vesicular monoamine transporter 2

Moligand™

CAS#: 1392826-25-3
EC Number: 813-698-4
PubChem CID: 73437646

Item Number

D609844

Grouped product items
SKU	Size	Availability	Price	Qty
D609844-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,400.90
D609844-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Vesicular monoamine transporter 2 Inhibitor

Basic Description

Synonyms	Tetrabenazine-d6\|1392826-25-3\|Deutetrabenazine\|Tetrabenazine D6\|SD809\|(3R,11bR)-3-(2-methylpropyl)-9,10-bis(trideuteriomethoxy)-1,3,4,6,7,11b-hexahydrobenzo[a]quinolizin-2-one\|rel-(3R,11bR)-3-isobutyl-9,10-bis(methoxy-d3)-1,3,4,6,7,11b-hexahydro-2H-pyrido
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Vesicular monoamine transporter 2

Names and Identifiers

IUPAC Name	(3R,11bR)-3-(2-methylpropyl)-9,10-bis(trideuteriomethoxy)-1,3,4,6,7,11b-hexahydrobenzo[a]quinolizin-2-one
INCHI	InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/t14-,16-/m1/s1/i3D3,4D3
InChi Key	MKJIEFSOBYUXJB-VFJJUKLQSA-N
Canonical SMILES	CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC
Isomeric SMILES	[2H]C([2H])([2H])OC1=C(C=C2[C@H]3CC(=O)[C@@H](CN3CCC2=C1)CC(C)C)OC([2H])([2H])[2H]
Alternate CAS	1392826-25-3
PubChem CID	73437646
MeSH Entry Terms	Austedo;deutetrabenazine

PubChem CID

73437646

CAS Registry No.

1392826-25-3

References

1. Huntington Study Group. (2006) Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trial.. Neurology, 66 (3): (366-72). [PMID:16476934]
2. Geschwind MD, Paras N. (2016) Deutetrabenazine for Treatment of Chorea in Huntington Disease.. JAMA, 316 (1): (33-5). [PMID:27380339]
3. Huntington Study Group, Frank S, Testa CM, Stamler D, Kayson E, Davis C, Edmondson MC, Kinel S, Leavitt B, Oakes D et al.. (2016) Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease: A Randomized Clinical Trial.. JAMA, 316 (1): (40-50). [PMID:27380342]
4. Gant TG. (2014) Using deuterium in drug discovery: leaving the label in the drug.. J Med Chem, 57 (9): (3595-611). [PMID:24294889]
5. Fernandez HH, Factor SA, Hauser RA, Jimenez-Shahed J, Ondo WG, Jarskog LF, Meltzer HY, Woods SW, Bega D, LeDoux MS et al.. (2017) Randomized controlled trial of deutetrabenazine for tardive dyskinesia: The ARM-TD study.. Neurology, 88 (21): (2003-2010). [PMID:28446646]
6. Claassen DO, Carroll B, De Boer LM, Wu E, Ayyagari R, Gandhi S, Stamler D. (2017) Indirect tolerability comparison of Deutetrabenazine and Tetrabenazine for Huntington disease.. J Clin Mov Disord, 4 (3): (3). [PMID:28265459]
7. Anderson KE, Stamler D, Davis MD, Factor SA, Hauser RA, Isojärvi J, Jarskog LF, Jimenez-Shahed J, Kumar R, McEvoy JP et al.. (2017) Deutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia (AIM-TD): a double-blind, randomised, placebo-controlled, phase 3 trial.. Lancet Psychiatry, 4 (8): (595-604). [PMID:28668671]

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deutetrabenazine , CAS No.1392826-25-3, Inhibitor of Vesicular monoamine transporter 2

Basic Description

Associated Targets

SLC18A2 Tclin Synaptic vesicular amine transporter 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

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