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Dexamethasone - 98%, high purity , CAS No.50-02-2

  • ≥98%
Item Number
D137736
Grouped product items
SKUSizeAvailabilityPrice Qty
D137736-1g
1g
In stock
$11.90
D137736-5g
5g
In stock
$40.90
D137736-25g
25g
In stock
$142.90
D137736-100g
100g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$399.90

Anti-inflammatory glucocorticoid

Basic Description

Synonymsdexamethasone|50-02-2|Decadron|Maxidex|Hexadecadrol|Dexamethazone|Dexasone|Hexadrol|Aeroseb-Dex|Fluormethylprednisolone|Desametasone|Superprednol|Visumetazone|Cortisumman|Decaderm|Decaspray|Dexacortal|Dexacortin|Gammacorten|Millicorten|Oradexon|Auxiron|Ca
Specifications & Purity≥98%
Biochemical and Physiological MechanismsDexamethasone is an antiinflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
An antiinflammatory glucocorticoid

Product Properties

ALogP1.9

Names and Identifiers

Pubchem Sid488179921
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179921
IUPAC Name (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
INCHI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChi Key UREBDLICKHMUKA-CXSFZGCWSA-N
Canonical SMILES CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
Isomeric SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
WGK Germany 2
RTECS TU3980000
Alternate CAS 23495-06-9,50-02-2
PubChem CID 5743
NSC Number 34521
MeSH Entry Terms Decaject;Decaject L.A.;Decaject-L.A.;Decameth;Decaspray;Dexamethasone;Dexasone;Dexpak;Hexadecadrol;Hexadrol;Maxidex;Methylfluorprednisolone;Millicorten;Oradexon
Molecular Weight 392.46
Beilstein 2066651

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

18 results found

Lot NumberCertificate TypeDateItem
F2401141Certificate of AnalysisMay 16, 2024 D137736
F2401140Certificate of AnalysisMay 16, 2024 D137736
F2401127Certificate of AnalysisMay 16, 2024 D137736
F2401135Certificate of AnalysisMay 16, 2024 D137736
E2416548Certificate of AnalysisMar 27, 2024 D137736
L2318363Certificate of AnalysisDec 06, 2023 D137736
L2318362Certificate of AnalysisDec 06, 2023 D137736
L2318361Certificate of AnalysisDec 06, 2023 D137736
L2318360Certificate of AnalysisDec 06, 2023 D137736
A2309635Certificate of AnalysisNov 25, 2022 D137736
A2309321Certificate of AnalysisNov 25, 2022 D137736
J2323065Certificate of AnalysisNov 25, 2022 D137736
A2309299Certificate of AnalysisNov 25, 2022 D137736
A2309298Certificate of AnalysisNov 25, 2022 D137736
A2309297Certificate of AnalysisNov 25, 2022 D137736
A2309296Certificate of AnalysisNov 25, 2022 D137736
K2210229Certificate of AnalysisNov 16, 2022 D137736
K2210230Certificate of AnalysisNov 16, 2022 D137736

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Chemical and Physical Properties

SolubilitySoluble in ethanol (25 mg/ml), and DMSO (25 mg/ml). Insoluble in water.
SensitivityLight & Air Sensitive.
Melt Point(°C)262-264°C

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS09,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H373:Causes damage to organs through prolonged or repeated exposure

H317:May cause an allergic skin reaction

H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled

H410:Very toxic to aquatic life with long lasting effects

H360:May damage fertility or the unborn child

H361:Suspected of damaging fertility or the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P284:[In case of inadequate ventilation] Wear respiratory protection.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P391:Collect spillage.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P318:if exposed or concerned, get medical advice.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.

WGK Germany 2
RTECS TU3980000

Related Documents

References

1. Walford HH et al..  (2014)  Increased ILC2s in the eosinophilic nasal polyp endotype are associated with corticosteroid responsiveness..  Clin Immunol,  155  (126-35).  [PMID:25236785]

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