DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with an IC 50 of ∼0.1-0.4 μM. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9.
In Vitro
DFP00173 inhibits the glycerol permeability of human erythrocytes with an IC 50 of ~0.2 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
