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DG 041 - ≥98%(HPLC), high purity , CAS No.861238-35-9, Antagonist of EP 3 receptor
Potent and selective EP3antagonist; antiplatelet and antithrombotic
Basic Description Synonyms DG-041|861238-35-9|DTSI|UNII-1844425CLP|1844425CLP|CHEMBL565591|2-Propenamide, 3-(1-((2,4-dichlorophenyl)methyl)-5-fluoro-3-methyl-1H-indol-7-yl)-N-((4,5-dichloro-2-thienyl)sulfonyl)-, (2E)-|(E)-3-[1-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methylindol-7-y Specifications & Purity Moligand™, ≥98%(HPLC) Biochemical and Physiological Mechanisms Potent and selective EP3antagonist (IC50= 4.6 nM). Inhibits PGE2facilitation of platelet aggregationin vitroandex vivo. Displays good plasma and metabolic stability. Does not affect bleeding time in rats. Antiplatelet and antithrombotic. Storage Temp Store at 2-8°C Shipped In Wet ice Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of EP 3 receptor
Names and Identifiers IUPAC Name (E)-3-[1-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methylindol-7-yl]-N-(4,5-dichlorothiophen-2-yl)sulfonylprop-2-enamide INCHI InChI=1S/C23H15Cl4FN2O3S2/c1-12-10-30(11-14-2-4-15(24)7-18(14)25)22-13(6-16(28)8-17(12)22)3-5-20(31)29-35(32,33)21-9-19(26)23(27)34-21/h2-10H,11H2,1H3,(H,29,31)/b5-3+ InChi Key BFBTVZNKWXWKNZ-HWKANZROSA-N Canonical SMILES CC1=CN(C2=C(C=C(C=C12)F)C=CC(=O)NS(=O)(=O)C3=CC(=C(S3)Cl)Cl)CC4=C(C=C(C=C4)Cl)Cl Isomeric SMILES CC1=CN(C2=C(C=C(C=C12)F)/C=C/C(=O)NS(=O)(=O)C3=CC(=C(S3)Cl)Cl)CC4=C(C=C(C=C4)Cl)Cl PubChem CID 11296282 Molecular Weight 592.32
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 59.23, Max Conc. mM: 100
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K2204282