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DIDS , CAS No.53005-05-3, Channel blocker of CaCC;Channel blocker of ClC-6;Channel blocker of ClC-7;Channel blocker of ClC-Ka;Channel blocker of ClC-Kb

Moligand™

CAS#: 53005-05-3
PubChem CID: 40600

Item Number

D609876

Grouped product items
SKU	Size	Availability	Price	Qty
D609876-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,400.90
D609876-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

CaCC Channel blocker ClC-6 Channel blocker ClC-7 Channel blocker ClC-Ka Channel blocker ClC-Kb Channel blocker Maxi Cl⁻ Channel blocker VRAC Channel blocker

Basic Description

Synonyms	152216-76-7\|Benzenesulfonic acid, 2,2'-(1,2-ethenediyl)bis[5-isothiocyanato-\|5-isothiocyanato-2-[2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzenesulfonic acid\|Benzenesulfonic acid, 2,2'-(1,2-ethenediyl)bis(5-isothiocyanato-\|Benzenesulfonic acid, 2,2'-[1,
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of CaCC;Channel blocker of ClC-6;Channel blocker of ClC-7;Channel blocker of ClC-Ka;Channel blocker of ClC-Kb

Associated Targets

ANO1 Tclin Anoctamin-1 0 Activities

Discover Target: ANO1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLCNKB Tchem Chloride channel protein ClC-Kb 0 Activities

Discover Target: CLCNKB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLCN6 Tchem Chloride transport protein 6 1 Activities

Discover Target: CLCN6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLCN7 Tchem H(+)/Cl(-) exchange transporter 7 1 Activities

Discover Target: CLCN7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLCNKA Tchem Chloride channel protein ClC-Ka 0 Activities

Discover Target: CLCNKA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5-isothiocyanato-2-[2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzene-1-sulfonic acid
INCHI	InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)
InChi Key	YSCNMFDFYJUPEF-UHFFFAOYSA-N
Canonical SMILES	S=C=Nc1ccc(c(c1)S(=O)(=O)O)C=Cc1ccc(cc1S(=O)(=O)O)N=C=S
Isomeric SMILES	C1=CC(=C(C=C1N=C=S)S(=O)(=O)O)C=CC2=C(C=C(C=C2)N=C=S)S(=O)(=O)O
PubChem CID	40600

PubChem CID

40600

Wikipedia

DIDS

CAS Registry No.

53005-05-3

References

1. Baldwin AG, Brough D, Freeman S. (2016) Inhibiting the Inflammasome: A Chemical Perspective.. J Med Chem, 59 (5): (1691-710). [PMID:26422006]
2. Becq F, Hamon Y, Bajetto A, Gola M, Verrier B, Chimini G. (1997) ABC1, an ATP binding cassette transporter required for phagocytosis of apoptotic cells, generates a regulated anion flux after expression in Xenopus laevis oocytes.. J Biol Chem, 272 (5): (2695-9). [PMID:9006906]
3. Hamon Y, Luciani MF, Becq F, Verrier B, Rubartelli A, Chimini G. (1997) Interleukin-1beta secretion is impaired by inhibitors of the Atp binding cassette transporter, ABC1.. Blood, 90 (8): (2911-5). [PMID:9376570]

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