Grouped product items

SKU

Size

Availability

Price

Qty

D134051-5ml

5ml

In stock

$9.90

D134051-25ml

25ml

Available within 4-8 weeks(?)

$18.90

D134051-50ml

50ml

In stock

$32.90

D134051-100ml

100ml

Available within 8-12 weeks(?)

$58.90

D134051-250ml

250ml

Available within 4-8 weeks(?)

$131.90

D134051-500ml

500ml

Available within 8-12 weeks(?)

$236.90

Basic Description

Synonyms	Diethyl ethoxymethylenemalonate\|87-13-8\|Diethyl 2-(ethoxymethylene)malonate\|Diethyl (ethoxymethylene)malonate\|Ethoxymethylenemalonic acid diethyl ester\|Propanedioic acid, (ethoxymethylene)-, diethyl ester\|Diethyl Ethoxymethylidenemalonate\|1,3-diethyl 2-(e
Specifications & Purity	≥98.0%(GC)
Shipped In	Normal
Product Description	Intermediate for the production of Flumequine.

Names and Identifiers

IUPAC Name	diethyl 2-(ethoxymethylidene)propanedioate
INCHI	InChI=1S/C10H16O5/c1-4-13-7-8(9(11)14-5-2)10(12)15-6-3/h7H,4-6H2,1-3H3
InChi Key	LTMHNWPUDSTBKD-UHFFFAOYSA-N
Canonical SMILES	CCOC=C(C(=O)OCC)C(=O)OCC
Isomeric SMILES	CCOC=C(C(=O)OCC)C(=O)OCC
WGK Germany	1
RTECS	OO1100000
PubChem CID	6871
Molecular Weight	216.23
Beilstein	3469
Reaxy-Rn	609193

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

6 results found

Lot Number	Certificate Type	Date	Item
A1916151	Certificate of Analysis	Jun 12, 2024	D134051
C2224194	Certificate of Analysis	Jan 08, 2024	D134051
F2320095	Certificate of Analysis	Apr 18, 2023	D134051
G2115029	Certificate of Analysis	Apr 18, 2023	D134051
L1415011	Certificate of Analysis	Sep 16, 2022	D134051
C2224195	Certificate of Analysis	Mar 08, 2022	D134051

Chemical and Physical Properties

Solubility	Soluble in Chloroform, Dichloromethane and Methanol., Soluble in Chloroform, Dichloromethane and Methanol.
Refractive Index	1.46
Flash Point(°F)	291.2 °F
Flash Point(°C)	155°C(lit.)
Boil Point(°C)	166 °C/19 mmHg
Melt Point(°C)	-33 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS05, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H314:Causes severe skin burns and eye damage H302:Harmful if swallowed H318:Causes serious eye damage H317:May cause an allergic skin reaction
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell.
WGK Germany	1
RTECS	OO1100000
Reaxy-Rn	609193

References

1. J Girón,M Alaiz,E Vioque. (1992-10-01) High-performance liquid chromatographic determination of N-epsilon-(2-propenal)lysine in biological samples after derivatization with diethylethoxymethylenemalonate.. Analytical biochemistry, 206 ((1)): (155-160). [PMID:1456428]
2. Sergio Gómez-Alonso,Isidro Hermosín-Gutiérrez,Esteban García-Romero. (2007-02-01) Simultaneous HPLC analysis of biogenic amines, amino acids, and ammonium ion as aminoenone derivatives in wine and beer samples.. Journal of agricultural and food chemistry, 55 ((3)): (608-613). [PMID:17263449]
3. Riin Rebane,Koit Herodes. (2010-06-29) A sensitive method for free amino acids analysis by liquid chromatography with ultraviolet and mass spectrometric detection using precolumn derivatization with diethyl ethoxymethylenemalonate: application to the honey analysis.. Analytica chimica acta, 672 ((1-2)): (79-84). [PMID:20579494]
4. Benoit Bach,Stephanie Le Quere,Patrick Vuchot,Magali Grinbaum,Laurent Barnavon. (2012-06-13) Validation of a method for the analysis of biogenic amines: histamine instability during wine sample storage.. Analytica chimica acta, 732 (114-119). [PMID:22688042]
5. Maarja-Liisa Oldekop,Koit Herodes,Riin Rebane. (2014-08-12) Study of the matrix effects and sample dilution influence on the LC-ESI-MS/MS analysis using four derivatization reagents.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967 (147-155). [PMID:25106031]
6. Patricia Alvarez-Sieiro,Begoña Redruello,Victor Ladero,Elena Cañedo,M Cruz Martin,María Fernández,Miguel A Alvarez. (2014-08-31) Solubilization of gliadins for use as a source of nitrogen in the selection of bacteria with gliadinase activity.. Food chemistry, 168 (439-444). [PMID:25172732]
7. Cristina Megías,Isabel Cortés-Giraldo,Julio Girón-Calle,Javier Vioque,Manuel Alaiz. (2014-10-05) Determination of L-canavanine and other free amino acids in Vicia disperma (Fabaceae) seeds by precolumn derivatization using diethyl ethoxymethylenemalonate and reversed-phase high-performance liquid chromatography.. Talanta, 131 (95-98). [PMID:25281078]
8. Marta Perez,Marina Calles-Enríquez,Ingolf Nes,Maria Cruz Martin,Maria Fernandez,Victor Ladero,Miguel A Alvarez. (2014-12-23) Tyramine biosynthesis is transcriptionally induced at low pH and improves the fitness of Enterococcus faecalis in acidic environments.. Applied microbiology and biotechnology, 99 ((8)): (3547-3558). [PMID:25529314]
9. J L Ordóñez,F Sainz,R M Callejón,A M Troncoso,M J Torija,M C García-Parrilla. (2015-02-24) Impact of gluconic fermentation of strawberry using acetic acid bacteria on amino acids and biogenic amines profile.. Food chemistry, 178 (221-228). [PMID:25704705]
10. Silvia Pérez-Magariño,Leticia Martínez-Lapuente,Marta Bueno-Herrera,Miriam Ortega-Heras,Zenaida Guadalupe,Belén Ayestarán. (2015-06-02) Use of Commercial Dry Yeast Products Rich in Mannoproteins for White and Rosé Sparkling Wine Elaboration.. Journal of agricultural and food chemistry, 63 ((23)): (5670-5681). [PMID:26027899]
11. Ke Tang,Liang Hu,Jingwei Ma,Huafeng Zhang,Yi Zhang,Yong Li,Ruihua Ma,Shunqun Luo,Dongbo Liu,Guoxian Long,Mei Han,Shunfang Liu,Anping Song,Meizhu Shen,Guoqing Hu,Bo Huang. (2015-06-03) Brief Report: Human Mesenchymal Stem-Like Cells Facilitate Floating Tumorigenic Cell Growth via Glutamine-Ammonium Cycle.. Stem cells (Dayton, Ohio), 33 ((9)): (2877-2884). [PMID:26031226]
12. M Alaiz,J L Navarro,J Girón,E Vioque. (1992-02-07) Amino acid analysis by high-performance liquid chromatography after derivatization with diethyl ethoxymethylenemalonate.. Journal of chromatography, 591 ((1-2)): (181-186). [PMID:1613051]
13. T Nishihata,M Miyake,A Kamada. (1984-09-01) Study of the mechanism behind adjuvant action of diethylethoxymethylene malonate enhancing the rectal absorption of cefmetazole and lysozyme.. Journal of pharmacobio-dynamics, 7 ((9)): (607-613). [PMID:6597309]
14. Riin Rebane,Koit Herodes,Ivo Leito. (2011-10-26) Analysis of selenomethylselenocysteine and selenomethionine by LC-ESI-MS/MS with diethyl ethoxymethylenemalonate derivatization.. The Analyst, 136 ((24)): (5241-5246). [PMID:22024646]
15. Hyun Joong Kim,Yong Hyun Kim,Ji-Hyun Shin,Shashi Kant Bhatia,Ganesan Sathiyanarayanan,Hyung-Min Seo,Kwon Young Choi,Yung-Hun Yang,Kyungmoon Park. (2015-02-13) Optimization of Direct Lysine Decarboxylase Biotransformation for Cadaverine Production with Whole-Cell Biocatalysts at High Lysine Concentration.. Journal of microbiology and biotechnology, 25 ((7)): (1108-1113). [PMID:25674800]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Diethyl Ethoxymethylidenemalonate - ≥98.0%(GC), high purity , CAS No.87-13-8