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D106364-1g

In stock

$30.90

D106364-5g

Available within 4-8 weeks(?)

$118.90

D106364-25g

25g

Available within 4-8 weeks(?)

$347.90

D106364-100g

100g

Available within 4-8 weeks(?)

$1,251.90

Basic Description

Synonyms	23911-26-4 \| DTPA-Anhydride \| 2-(Bis(2-(2,6-dioxomorpholino)ethyl)amino)acetic acid \| Diethylenetriaminepentaacetic dianhydride \| Cyclic dtpa anhydride \| Dtpa cyclic anhydride \| dtpa-dianhydride \| 2-[bis[2-(2,6-dioxomorpholin-4-yl)ethyl]amino]acetic acid \| DTPA dianhydri
Specifications & Purity	98%
Shipped In	Normal
Product Description	Employed in the synthesis of macrocyclic ligands and lanthanide complexes that are useful as MRI enhancers

Names and Identifiers

IUPAC Name	2-[bis[2-(2,6-dioxomorpholin-4-yl)ethyl]amino]acetic acid
INCHI	InChI=1S/C14H19N3O8/c18-10(19)5-15(1-3-16-6-11(20)24-12(21)7-16)2-4-17-8-13(22)25-14(23)9-17/h1-9H2,(H,18,19)
InChi Key	RAZLJUXJEOEYAM-UHFFFAOYSA-N
Canonical SMILES	C1C(=O)OC(=O)CN1CCN(CCN2CC(=O)OC(=O)C2)CC(=O)O
Isomeric SMILES	C1C(=O)OC(=O)CN1CCN(CCN2CC(=O)OC(=O)C2)CC(=O)O
WGK Germany	3
PubChem CID	100825
Molecular Weight	357.32
Beilstein	1230954
Reaxy-Rn	1230954

Certificates

Certificate of Analysis(COA)

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10 results found

Lot Number	Certificate Type	Date	Item
D23191091	Certificate of Analysis	Mar 17, 2023	D106364
D23191111	Certificate of Analysis	Mar 17, 2023	D106364
D2319245	Certificate of Analysis	Mar 17, 2023	D106364
D2319274	Certificate of Analysis	Mar 17, 2023	D106364
K2330160	Certificate of Analysis	Mar 17, 2023	D106364
J2211468	Certificate of Analysis	Oct 15, 2022	D106364
J2228410	Certificate of Analysis	Oct 09, 2022	D106364
J2228433	Certificate of Analysis	Oct 09, 2022	D106364
J2228434	Certificate of Analysis	Oct 09, 2022	D106364
J2228484	Certificate of Analysis	Oct 09, 2022	D106364

Chemical and Physical Properties

Solubility	Soluble in Methanol
Sensitivity	Moisture sensitive.
Melt Point(°C)	182-184°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
Reaxy-Rn	1230954

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References

1. C H Paik,J J Hong,M A Ebbert,S C Heald,R C Reba,W C Eckelman. (1985-05-01) Relative reactivity of DTPA, immunoreactive antibody-DTPA conjugates, and nonimmunoreactive antibody-DTPA conjugates toward indium-111.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 26 ((5)): (482-487). [PMID:3989604]
2. J Powe,K Y Pak,C H Paik,Z Steplewski,M A Ebbert,D Herlyn,C Ernst,A Alavi,W C Eckelman,R C Reba. (1984-01-01) Labeling monoclonal antibodies and F(ab')2 fragments with (111In) indium using cyclic DTPA anhydride and their in vivo behavior in mice bearing human tumor xenografts.. Cancer drug delivery, 1 ((2)): (125-135). [PMID:6544629]
3. A Najafi,R L Childs,D J Hnatowich. (1984-06-01) Coupling antibody with DTPA--an alternative to the cyclic anhydride.. The International journal of applied radiation and isotopes, 35 ((6)): (554-557). [PMID:6547405]
4. C H Paik,M A Ebbert,P R Murphy,C R Lassman,R C Reba,W C Eckelman,K Y Pak,J Powe,Z Steplewski,H Koprowski. (1983-12-01) Factors influencing DTPA conjugation with antibodies by cyclic DTPA anhydride.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 24 ((12)): (1158-1163). [PMID:6644376]
5. Chad R Haney,Paul W Buehler,Anil Gulati. (2005-08-17) Synthesis and characterization of a novel DTPA polymerized hemoglobin based oxygen carrier.. Biochimica et biophysica acta, 1725 ((3)): (358-369). [PMID:16102904]
6. Er-Yuan Chuang,Kun-Ju Lin,Po-Yen Lin,Hsin-Lung Chen,Shiaw-Pyng Wey,Fwu-Long Mi,Hsu-Chan Hsiao,Chiung-Tong Chen,Hsing-Wen Sung. (2015-07-02) Self-assembling bubble carriers for oral protein delivery.. Biomaterials, 64 (115-124). [PMID:26132436]
7. Ying-Hsia Shih,Tsai-Yueh Luo,Ping-Fang Chiang,Cheng-Jung Yao,Wuu-Jyh Lin,Cheng-Liang Peng,Ming-Jium Shieh. (2017-04-27) EGFR-targeted micelles containing near-infrared dye for enhanced photothermal therapy in colorectal cancer.. Journal of controlled release : official journal of the Controlled Release Society, 258 (196-207). [PMID:28445743]
8. Yuanyuan Li,Shunjie Liu,Xun Zhao,Ying Wang,Jianhua Liu,Xianhong Wang,Lehui Lu. (2017-12-01) CO. Theranostics, 7 ((19)): (4689-4698). [PMID:29187896]
9. Joshua Owen,Eloise Thomas,Jyothi Menon,Michael Gray,Irini Skaripa-Koukelli,Martin R Gill,Sheena Wallington,Rebecca L Miller,Katherine A Vallis,Robert Carlisle. (2020-01-01) Indium-111 labelling of liposomal HEGF for radionuclide delivery via ultrasound-induced cavitation.. Journal of controlled release : official journal of the Controlled Release Society, 319 (222-233). [PMID:31891732]
10. Paweł K Halik,Piotr F J Lipiński,Joanna Matalińska,Przemysław Koźmiński,Aleksandra Misicka,Ewa Gniazdowska. (2020-08-23) Radiochemical Synthesis and Evaluation of Novel Radioconjugates of Neurokinin 1 Receptor Antagonist Aprepitant Dedicated for NK1R-Positive Tumors.. Molecules (Basel, Switzerland), 25 ((16)): [PMID:32824729]
11. Poorya Najjari Nabi,Nasim Vahidfar,Mohammad Reza Tohidkia,Ali Asghar Hamidi,Yadollah Omidi,Ayuob Aghanejad. (2021-02-01) Mucin-1 conjugated polyamidoamine-based nanoparticles for image-guided delivery of gefitinib to breast cancer.. International journal of biological macromolecules, 174 (185-197). [PMID:33516855]
12. N Willmott,T Murray,R Carlton,Y Chen,H Logan,G McCurrach,R G Bessent,J A Goldberg,J Anderson,J H McKillop. (1991-01-01) Development of radiolabelled albumin microspheres: a comparison of gamma-emitting radioisotopes of iodine (131I) and indium (111In/113mIn).. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 18 ((7)): (687-694). [PMID:1787077]
13. B M Kinsey,R M Macklis,J M Ferrara,W W Layne,S J Burakoff,A I Kassis. (1988-01-01) Efficient conjugation of DTPA to an IgM monoclonal antibody in ascites fluid.. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 15 ((3)): (285-292). [PMID:2898458]
14. M Fischer,U J Hoffmann,W Köhnlein,D Skutta. (1986-12-01) Radioimmunoscintigraphy with anti-thyroglobulin monoclonal antibodies.. Nuklearmedizin. Nuclear medicine, 25 ((6)): (232-234). [PMID:3808965]
15. T S Wang,S C Srivastava,R A Fawwaz,P Giacomini,S Ferrone,P Richards,M Hardy,P O Alderson. (1984-08-01) A comparison of the cyclic anhydride and mixed anhydride methods for 111In-DTPA chelation to monoclonal antibodies.. Nuklearmedizin. Nuclear medicine, 23 ((4)): (193-195). [PMID:6483630]
16. M Fani,S Vranjes,S C Archimandritis,S Potamianos,S Xanthopoulos,P Bouziotis,A D Varvarigou. (2002-11-16) Labeling of monoclonal antibodies with 153Sm for potential use in radioimmunotherapy.. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 57 ((5)): (665-674). [PMID:12433040]
17. MyeongJu Moon,Reju George Thomas,Seon-U Heo,Myong-Suk Park,Woo Kyun Bae,Suk Hee Heo,Nam Yeol Yim,Yong Yeon Jeong. (2015-01-22) A Hyaluronic Acid-Conjugated Gadolinium Hepatocyte-Specific T1 Contrast Agent for Liver Magnetic Resonance Imaging.. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 17 ((4)): (497-503). [PMID:25604386]
18. Yongbo Yang,Li Lin,Lijia Jing,Xiuli Yue,Zhifei Dai. (2017-06-29) CuInS. ACS applied materials & interfaces, 9 ((28)): (23450-23457). [PMID:28656760]
19. Farid N Faruqu,Julie Tzu-Wen Wang,Lizhou Xu,Luke McNickle,Eden Ming-Yiu Chong,Adam Walters,Mark Gurney,Aled Clayton,Lesley A Smyth,Robert Hider,Jane Sosabowski,Khuloud T Al-Jamal. (2019-05-01) Membrane Radiolabelling of Exosomes for Comparative Biodistribution Analysis in Immunocompetent and Immunodeficient Mice - A Novel and Universal Approach.. Theranostics, 9 ((6)): (1666-1682). [PMID:31037130]

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Diethylenetriaminepentaacetic acid dianhydride - 98%, high purity , CAS No.23911-26-4

Basic Description

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

FAQs and Articles

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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