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Difluprednate - ≥98%, high purity , Glucocorticoid receptor agonist, CAS No.23674-86-4, Glucocorticoid receptor agonist
Basic Description Synonyms difluprednate | 23674-86-4 | Durezol | DFBA | Myser | Difluprednato | Difluprednatum | Epitopic | UNII-S8A06QG2QE | Difluoroprednisolone butyrate acetate | [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,1 Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms Difluprednate(Durezol) is a corticosteroid, approved difluprednate for the treatment of post-operative ocular inflammation and pain. Storage Temp Store at 2-8°C Shipped In Wet ice Grade Moligand™ Action Type AGONIST Mechanism of action Glucocorticoid receptor agonist Note 500mg、100mg卖完停产，不再备货 Product Description Difluprednate (difluoroprednisolone butyrate acetate, or DFBA) is a synthetic difluorinated prednisolone derivative, it is originally developed for dermatologic applications
Names and Identifiers IUPAC Name [(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate INCHI InChI=1S/C27H34F2O7/c1-5-6-23(34)36-26(22(33)14-35-15(2)30)10-8-17-18-12-20(28)19-11-16(31)7-9-24(19,3)27(18,29)21(32)13-25(17,26)4/h7,9,11,17-18,20-21,32H,5-6,8,10,12-14H2,1-4H3/t17-,18-,20-,21-,24-,25-,26-,27-/m0/s1 InChi Key WYQPLTPSGFELIB-JTQPXKBDSA-N Canonical SMILES CCCC(=O)OC1(CCC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C(=O)COC(=O)C Isomeric SMILES CCCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O)C)C(=O)COC(=O)C WGK Germany 2 RTECS TU3831500 PubChem CID 443936 Molecular Weight 508.55
Chemical and Physical Properties Solubility DMSO 102 mg/mL Water <1 mg/mL Ethanol 25 mg/mL Sensitivity Heat Sensitive Specific Rotation[α] 31° (C=2,Dioxane) Melt Point(°C) 193 °C
Safety and Hazards(GHS) Pictogram(s) GHS08 , GHS07 Signal Danger Hazard Statements H373: Causes damage to organs through prolonged or repeated exposure
H360: May damage fertility or the unborn child
H302+H312+H332: Harmful if swallowed, in contact with skin or if inhaled
H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P271: Use only outdoors or in a well-ventilated area.
P270: Do not eat, drink or smoke when using this product.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P362+P364: Take off contaminated clothing and wash it before reuse.
P330: Rinse mouth.
P203: Obtain, read and follow all safety instructions before use.
P301+P317: IF SWALLOWED: Get medical help.
P318: if exposed or concerned, get medical advice.
P317: Get emergency medical help.
P319: Get medical help if you feel unwell.
WGK Germany 2 RTECS TU3831500 Merck Index 3152
References 1. Tajika T, Waki M, Tsuzuki M, Kida T, Sakaki H. (2011) Pharmacokinetic features of difluprednate ophthalmic emulsion in rabbits as determined by glucocorticoid receptor-binding bioassay.. J Ocul Pharmacol Ther, 27 (1): (29-34). [PMID:21182429 ]
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