Dihydroartemisinin - ≥98%, high purity , CAS No.71939-50-9

Item Number
D140839
Grouped product items
SKUSizeAvailabilityPrice Qty
D140839-1g
1g
In stock
$16.90
D140839-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$59.90
D140839-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$169.90

Induces cell cycle arrest and inhibits cell migration in cancer cells

Basic Description

Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsInduces cell cycle arrest and inhibits cell migration in cancer cells. Depletes cellular iron via transferrin receptor 1. Antimalarial and antitumor agent. Orally active. Active in vivo and in vitro .
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
GradeMoligand™
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Dihydro Artemisinin is an active antimalarial metabolite. Dihydro Artemisinin is also the main metabolite of Artemisinin, Arteether, Artemether, Artesunate.
An active antimalarial metabolite

Names and Identifiers

IUPAC Name (1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol
INCHI InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12+,13-,14-,15-/m1/s1
InChi Key BJDCWCLMFKKGEE-ISOSDAIHSA-N
Canonical SMILES CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)O)C
Isomeric SMILES C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)O)C
RTECS KD4165550
Alternate CAS 81496-82-4
PubChem CID 3000518
Molecular Weight 284.35
Reaxy-Rn 5813803

Certificates

Certificate of Analysis(COA)

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16 results found

Lot NumberCertificate TypeDateItem
L2406370Certificate of AnalysisDec 13, 2024 D140839
L2406397Certificate of AnalysisDec 13, 2024 D140839
L2406398Certificate of AnalysisDec 13, 2024 D140839
J2409283Certificate of AnalysisOct 11, 2024 D140839
J2409284Certificate of AnalysisOct 11, 2024 D140839
J2409285Certificate of AnalysisOct 11, 2024 D140839
J2409286Certificate of AnalysisOct 11, 2024 D140839
J2318332Certificate of AnalysisOct 25, 2023 D140839
J2318333Certificate of AnalysisOct 25, 2023 D140839
J2318334Certificate of AnalysisOct 25, 2023 D140839
I2206666Certificate of AnalysisSep 13, 2022 D140839
I2206667Certificate of AnalysisSep 13, 2022 D140839
I2206668Certificate of AnalysisSep 13, 2022 D140839
C2204427Certificate of AnalysisMar 11, 2022 D140839
C2204449Certificate of AnalysisMar 11, 2022 D140839
C2204452Certificate of AnalysisMar 11, 2022 D140839

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Chemical and Physical Properties

SolubilitySoluble in DMSO (57 mg/ml) at 25 °C, ethanol (14 mg/ml) at 25 °C, and water (<1 mg/ml) at 25 °C.
Sensitivityair & heat sensitive
Melt Point(°C)145-150℃

Safety and Hazards(GHS)

RTECS KD4165550
Reaxy-Rn 5813803
Merck Index 817

Related Documents

Citations of This Product

1. Jingjing Zhen, Faguang Ma, Rongxin Lin, Ming Yan, Yilin Wu.  (2024)  Porous MOFs-based self-assembled membrane with specific rebinding nanocages for selective recognition and separation at molecular level.  DESALINATION,  572  (117124).  [PMID:2501086] [10.1016/j.desal.2023.117124]
2. Weibai Bian, Ruixuan Zhang, Xiaohui Chen, Chuanxun Zhang, Minjia Meng.  (2023)  Three-Dimensional Porous PVDF Foam Imprinted Membranes with High Flux and Selectivity toward Artemisinin/Artemether.  MOLECULES,  28  (21): (7452).  [PMID:37959871] [10.3390/molecules28217452]
3. Kaicheng Zhang, Rongxin Lin, Ming Yan, Yilin Wu.  (2023)  Click-chemistry synergic MXene-functionalized flexible skeleton membranes for accurate recognition and separation.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  652  (3): (2005).  [PMID:37690308] [10.1016/j.jcis.2023.09.028]
4. Jiantang Liang, Lei Li, Hailong Tian, Zhihan Wang, Guowen Liu, Xirui Duan, Meiwen Guo, Jiaqi Liu, Wei Zhang, Edouard C. Nice, Canhua Huang, Weifeng He, Haiyuan Zhang, Qifu Li.  (2023)  Drug Repurposing-Based Brain-Targeting Self-Assembly Nanoplatform Using Enhanced Ferroptosis against Glioblastoma.  Small,    (2303073).  [PMID:37460404] [10.1002/smll.202303073]
5. Qi Duan, Junxia Wu.  (2023)  Dihydroartemisinin ameliorates cerebral I/R injury in rats via regulating VWF and autophagy-mediated SIRT1/FOXO1 pathway.  Open Medicine,  18  (1):   [PMID:37415610] [10.1515/med-2023-0698]
6. Jing Yan, Faguang Ma, Yilin Wu.  (2023)  Permselective and transparent wooden membrane with artemisinin-imprinted nanocages based on a MOFs@C3N4 self-assembly design.  Materials Today Nano,  23  (100369).  [PMID:] [10.1016/j.mtnano.2023.100369]
7. Jingsong Lu, Jing Yu, Wensheng Xie, Zhenhu Guo, Xiaohan Gao, Ying Li, Ziqing Zhang, Zeping Jin, Abdul Fahad, Shenglei Che, Lingyun Zhao, Yen Wei.  (2023)  Acidity-Triggered Charge-Convertible Conjugated Polymer for Dihydroartemisinin Delivery and Tumor-Specific Chemo-Photothermal Therapy.  ACS Applied Bio Materials,  (6): (2303–2313).  [PMID:37190932] [10.1021/acsabm.3c00169]
8. Shi Hanqiang, Xiong Lie, Yan Guang, Du Shuqin, Liu Jie, Shi Yanbo.  (2023)  Susceptibility of cervical cancer to dihydroartemisinin-induced ferritinophagy-dependent ferroptosis.  Frontiers in Molecular Biosciences,  10    [PMID:37065442] [10.3389/fmolb.2023.1156062]
9. Jing Yan, Kaicheng Zhang, Faguang Ma, Hang Cui, Yilin Wu.  (2023)  Scalable basswood-based PDA/GO-embedded self-assembly membrane within multilayered artemisinin-imprinted nanocage for high-selectivity cascading adsorption and transport.  CHEMICAL ENGINEERING JOURNAL,  462  (142277).  [PMID:] [10.1016/j.cej.2023.142277]
10. Wang Huai-Song, Xia Xingya, Wang Yingming, Lyu Weiping, Sang Mangmang, Gu Congcong, Liu Wenyuan, Zheng Feng.  (2021)  Anti-cancer adjuvant drug screening via epithelial-mesenchymal transition-related aptamer probe.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  413  (28): (6951-6962).  [PMID:34676432] [10.1007/s00216-021-03669-x]
11. Longkai Yang, Qiu Xiong, Yanbo Li, Peng Gao, Ben Xu, Hong Lin, Xin Li, Tsutomu Miyasaka.  (2021)  Artemisinin-passivated mixed-cation perovskite films for durable flexible perovskite solar cells with over 21% efficiency.  Journal of Materials Chemistry A,  (3): (1574-1582).  [PMID:] [10.1039/D0TA10717D]
12. Yilin Wu, Wendong Xing, Minjia Meng, Jian Lu, Faguang Ma, Jia Gao, Xinyu Lin, Chao Yu.  (2020)  Multiple-functional molecularly imprinted nanocomposite membranes for high-efficiency selective separation applications: An imitated core-shell TiO2@PDA-based MIMs design.  COMPOSITES PART B-ENGINEERING,  198  (108123).  [PMID:] [10.1016/j.compositesb.2020.108123]
13. Yao Yuyuan, Guo Qinglong, Cao Yue, Qiu Yangmin, Tan Renxiang, Yu Zhou, Zhou Yuxin, Lu Na.  (2018)  Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer.  JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,  37  (1): (1-14).  [PMID:30477536] [10.1186/s13046-018-0960-7]
14. Shoubing Wang, Ziran Xu.  (2016)  Effects of Dihydroartemisinin and Artemether on the Growth, Chlorophyll Fluorescence, and Extracellular Alkaline Phosphatase Activity of the Cyanobacterium Microcystis aeruginosa.  PLoS One,  11  (10): (e0164842).  [PMID:27755566] [10.1371/journal.pone.0164842]

References

1. Sanford M, McCormack PL.  (2015)  All chapters.  Guidelines for the Treatment of Malaria,  71  (13): (1755-70).  [PMID:26020088] [10.1021/op500134e]
2. Bang S et al..  (2021)  Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice..  Nat Commun,  12  (1704).  [PMID:33731716]
3. Jingjing Zhen, Faguang Ma, Rongxin Lin, Ming Yan, Yilin Wu.  (2024)  Porous MOFs-based self-assembled membrane with specific rebinding nanocages for selective recognition and separation at molecular level.  DESALINATION,  572  (117124).  [PMID:2501086] [10.1016/j.desal.2023.117124]
4. Weibai Bian, Ruixuan Zhang, Xiaohui Chen, Chuanxun Zhang, Minjia Meng.  (2023)  Three-Dimensional Porous PVDF Foam Imprinted Membranes with High Flux and Selectivity toward Artemisinin/Artemether.  MOLECULES,  28  (21): (7452).  [PMID:37959871] [10.3390/molecules28217452]
5. Kaicheng Zhang, Rongxin Lin, Ming Yan, Yilin Wu.  (2023)  Click-chemistry synergic MXene-functionalized flexible skeleton membranes for accurate recognition and separation.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  652  (3): (2005).  [PMID:37690308] [10.1016/j.jcis.2023.09.028]
6. Jiantang Liang, Lei Li, Hailong Tian, Zhihan Wang, Guowen Liu, Xirui Duan, Meiwen Guo, Jiaqi Liu, Wei Zhang, Edouard C. Nice, Canhua Huang, Weifeng He, Haiyuan Zhang, Qifu Li.  (2023)  Drug Repurposing-Based Brain-Targeting Self-Assembly Nanoplatform Using Enhanced Ferroptosis against Glioblastoma.  Small,    (2303073).  [PMID:37460404] [10.1002/smll.202303073]
7. Qi Duan, Junxia Wu.  (2023)  Dihydroartemisinin ameliorates cerebral I/R injury in rats via regulating VWF and autophagy-mediated SIRT1/FOXO1 pathway.  Open Medicine,  18  (1):   [PMID:37415610] [10.1515/med-2023-0698]
8. Jing Yan, Faguang Ma, Yilin Wu.  (2023)  Permselective and transparent wooden membrane with artemisinin-imprinted nanocages based on a MOFs@C3N4 self-assembly design.  Materials Today Nano,  23  (100369).  [PMID:] [10.1016/j.mtnano.2023.100369]
9. Jingsong Lu, Jing Yu, Wensheng Xie, Zhenhu Guo, Xiaohan Gao, Ying Li, Ziqing Zhang, Zeping Jin, Abdul Fahad, Shenglei Che, Lingyun Zhao, Yen Wei.  (2023)  Acidity-Triggered Charge-Convertible Conjugated Polymer for Dihydroartemisinin Delivery and Tumor-Specific Chemo-Photothermal Therapy.  ACS Applied Bio Materials,  (6): (2303–2313).  [PMID:37190932] [10.1021/acsabm.3c00169]
10. Shi Hanqiang, Xiong Lie, Yan Guang, Du Shuqin, Liu Jie, Shi Yanbo.  (2023)  Susceptibility of cervical cancer to dihydroartemisinin-induced ferritinophagy-dependent ferroptosis.  Frontiers in Molecular Biosciences,  10    [PMID:37065442] [10.3389/fmolb.2023.1156062]
11. Jing Yan, Kaicheng Zhang, Faguang Ma, Hang Cui, Yilin Wu.  (2023)  Scalable basswood-based PDA/GO-embedded self-assembly membrane within multilayered artemisinin-imprinted nanocage for high-selectivity cascading adsorption and transport.  CHEMICAL ENGINEERING JOURNAL,  462  (142277).  [PMID:] [10.1016/j.cej.2023.142277]
12. Wang Huai-Song, Xia Xingya, Wang Yingming, Lyu Weiping, Sang Mangmang, Gu Congcong, Liu Wenyuan, Zheng Feng.  (2021)  Anti-cancer adjuvant drug screening via epithelial-mesenchymal transition-related aptamer probe.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  413  (28): (6951-6962).  [PMID:34676432] [10.1007/s00216-021-03669-x]
13. Longkai Yang, Qiu Xiong, Yanbo Li, Peng Gao, Ben Xu, Hong Lin, Xin Li, Tsutomu Miyasaka.  (2021)  Artemisinin-passivated mixed-cation perovskite films for durable flexible perovskite solar cells with over 21% efficiency.  Journal of Materials Chemistry A,  (3): (1574-1582).  [PMID:] [10.1039/D0TA10717D]
14. Yilin Wu, Wendong Xing, Minjia Meng, Jian Lu, Faguang Ma, Jia Gao, Xinyu Lin, Chao Yu.  (2020)  Multiple-functional molecularly imprinted nanocomposite membranes for high-efficiency selective separation applications: An imitated core-shell TiO2@PDA-based MIMs design.  COMPOSITES PART B-ENGINEERING,  198  (108123).  [PMID:] [10.1016/j.compositesb.2020.108123]
15. Yao Yuyuan, Guo Qinglong, Cao Yue, Qiu Yangmin, Tan Renxiang, Yu Zhou, Zhou Yuxin, Lu Na.  (2018)  Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer.  JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,  37  (1): (1-14).  [PMID:30477536] [10.1186/s13046-018-0960-7]
16. Shoubing Wang, Ziran Xu.  (2016)  Effects of Dihydroartemisinin and Artemether on the Growth, Chlorophyll Fluorescence, and Extracellular Alkaline Phosphatase Activity of the Cyanobacterium Microcystis aeruginosa.  PLoS One,  11  (10): (e0164842).  [PMID:27755566] [10.1371/journal.pone.0164842]

Solution Calculators