Dihydrocytochalasin B - ≥98%(HPLC), high purity , CAS No.39156-67-7

  • ≥98%(HPLC)
Item Number
D139525
Grouped product items
SKUSizeAvailabilityPrice Qty
D139525-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$232.90
D139525-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,047.90

Cytokinesis inhibitor and induces changes in cell morphology and motility

View related series
Arp2/3 Complex Cytoskeleton

Basic Description

SynonymsMFCD12910542 | EINECS 254-324-4 | 21,22-Dihydrocytochalasan B | 7(S),20(R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E)-diene-1,23-dione | Cytochalasin H2B | dihydrocytochalasin B | 21,22-Dihydrophomin | 24-OXA(14)CYTOCHALASA-6(12),1
Specifications & Purity≥98%(HPLC)
Biochemical and Physiological MechanismsEffect on cell motility and morphology similar to that of cytochalasin B; does not inhibit glucose transport.Cytokinesis inhibitor and induces changes in cell morphology and motility. Disrupts actin structure and inhibits ability of serum growth factors t
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Dihydrocytochalasin B induces changes in cell morphology and motility with no effect on sugar transport. Dihydrocytochalasin B is used as specific marker in studies of high affinity cytochalasin binding sites unrelated to sugar transport. Dihydrocytochalasin B also disrupts the equilibrium between monomeric and polymeric actin.
Marker for high affinity cytochalasin B binding sites. Cytochalasins are used as tools in cytological research, and in in the field of actin polymerisation

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (1S,6R,10R,12E,14S,15S,17S,18S,19S)-19-benzyl-6,15-dihydroxy-10,17-dimethyl-16-methylidene-2-oxa-20-azatricyclo[12.7.0.01,18]henicos-12-ene-3,21-dione
INCHI InChI=1S/C29H39NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14,18-19,22-24,26-27,31,33H,3,7,9-10,13,15-17H2,1-2H3,(H,30,34)/b14-8+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
InChi Key WIULKAASLBZREV-RXPQEOCGSA-N
Canonical SMILES CC1CCCC(CCC(=O)OC23C(C=CC1)C(C(=C)C(C2C(NC3=O)CC4=CC=CC=C4)C)O)O
Isomeric SMILES C[C@@H]1CCC[C@H](CCC(=O)O[C@]23[C@@H](/C=C/C1)[C@@H](C(=C)[C@H]([C@H]2[C@@H](NC3=O)CC4=CC=CC=C4)C)O)O
WGK Germany 3
PubChem CID 6438347
Molecular Weight 481.62

Certificates

Certificate of Analysis(COA)

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Lot NumberCertificate TypeDateItem
K1908035Certificate of AnalysisAug 10, 2023 D139525

Chemical and Physical Properties

SolubilityAcetone, DMSO, 100% Ethanol, Methanol
SensitivityLight Sensitive
Melt Point(°C)204°C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS08
Signal Danger
Hazard Statements

H351:Suspected of causing cancer

H300:Fatal if swallowed

H310:Fatal in contact with skin

H330:Fatal if inhaled

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P284:[In case of inadequate ventilation] Wear respiratory protection.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P330:Rinse mouth.

P262:Do not get in eyes, on skin, or on clothing.

P320:Specific treatment is urgent (see ... on this label).

P361+P364:Take off immediately all contaminated clothing and wash it before reuse.

P203:Obtain, read and follow all safety instructions before use.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P318:if exposed or concerned, get medical advice.

P316:Get emergency medical help immediately.

WGK Germany 3

Related Documents

Solution Calculators