Call +1 (833) 552-7181 or Contact us Earn $25 in coupons on your first order with Aladdin!
Toggle Nav
My Cart
Search
Advanced Search
Menu
Sign In
྾
main product photo

Dihydroethidium - 10mM in DMSO, high purity , CAS No.104821-25-2

19 Citations
  • 10mM in DMSO
Item Number
D420461
Grouped product items
SKUSizeAvailabilityPrice Qty
D420461-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$240.90
Add to Wish List Compare
Bulk Order  SDS  DATASHEET

Cell-permeable blue fluorescent dye. Redox indicator.

Basic Description

SynonymsDihydroethidium | 104821-25-2 | Hydroethidine | 5-ethyl-6-phenyl-5,6-dihydrophenanthridine-3,8-diamine | PD-MY 003 | 5-ethyl-5,6-dihydro-6-phenyl-3,8-phenanthridinediamine | 5-ethyl-6-phenyl-6H-phenanthridine-3,8-diamine | 3pm1 | Dihydroethidium, >=95% | Hydroethidine;PD-M
Specifications & Purity10mM in DMSO
Storage TempProtected from light,Store at -80°C
Shipped InIce chest + Ice pads
Product Description

Hydroethidine operates effectively as a probe for measurement of reactive oxygen species. The dye enters cells freely and is dehydrogenated to ethidium bromide. The probe has been used extensively with NK cell and as a vital dye for identification of proliferation and hypoxic cells in tumors. Studies have been performed using neutrophils and endothelial cells as well as HL60 cells and macrophages. A major advantage of this probe is its ability to distinguish between superoxide and H2O2. Fluorescence emission occurs at around 600 nm.
Redox indicator. Blue fluorescence until oxidized to ethidium

Names and Identifiers

IUPAC Name 5-ethyl-6-phenyl-6H-phenanthridine-3,8-diamine
INCHI InChI=1S/C21H21N3/c1-2-24-20-13-16(23)9-11-18(20)17-10-8-15(22)12-19(17)21(24)14-6-4-3-5-7-14/h3-13,21H,2,22-23H2,1H3
InChi Key XYJODUBPWNZLML-UHFFFAOYSA-N
Canonical SMILES CCN1C(C2=C(C=CC(=C2)N)C3=C1C=C(C=C3)N)C4=CC=CC=C4
Isomeric SMILES CCN1C(C2=C(C=CC(=C2)N)C3=C1C=C(C=C3)N)C4=CC=CC=C4
WGK Germany 3
PubChem CID 128682
Molecular Weight 315.41
Beilstein 5107482

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

SensitivityAir sensitive.Light sensitive.

Safety and Hazards(GHS)

WGK Germany 3

Related Documents

 SDS

 Specification Sheet

Citations of This Product

1. Tongsheng Huang, Xin Hu, Shiyu Huang, Dong Liu, Lihua Chen, Qinghua Wu, Weifeng Zhu, Xiaoyong Zhang, Meiying Liu, Yen Wei.  (2024)  One-step synthesis of cyclodextrin-based fluorescent hyperbranched polymer as type I photosensitizer for effective photodynamic therapy.  DYES AND PIGMENTS,  223  (111928).  [PMID:]
2. Lei Qian, Hu Xu, Ruqiang Yuan, Weijing Yun, Yufang Ma.  (2024)  Formononetin ameliorates isoproterenol induced cardiac fibrosis through improving mitochondrial dysfunction.  BIOMEDICINE & PHARMACOTHERAPY,  170  (116000).  [PMID:38070245]
3. Ping Ping, Shasha Guan, Chaoxue Ning, Ting Yang, Yali Zhao, Pei Zhang, Zhitao Gao, Shihui Fu.  (2023)  Fabrication of blended nanofibrous cardiac patch transplanted with TGF-β3 and human umbilical cord MSCs-derived exosomes for potential cardiac regeneration after acute myocardial infarction.  Nanomedicine-Nanotechnology Biology and Medicine,  54  (16): (102708).  [PMID:37788793]
4. Mengmeng Pan, Ming Wang, Linjiao Yang, Yongli Song, Ming Jiang, Xu Yu, Li Xu.  (2023)  Construction of Metal Organic Framework-Derived Fe-N-C Oxidase Nanozyme for Rapid and Sensitive Detection of Alkaline Phosphatase.  Nanomaterials,  13  (18): (2496).  [PMID:37764526]
5. Ke Xue, Yongfei Zhao, Saidong Sun, Yuanhang Li, Jiankang Liang, Zhengjian Qi.  (2023)  NIR-AIEgens nanospheres featuring high-fidelity dynamic lipid droplet targeting, expediting ferroptosis to annihilating tumor in hypoxia.  CHEMICAL ENGINEERING JOURNAL,  470  (144125).  [PMID:]
6. Zhen Li, Yuanji Feng, Sijia Zhang, Tong Li, Huixin Li, Dianwei Wang, Kai Hao, Chaoliang He, Huayu Tian, Xuesi Chen.  (2023)  A Multifunctional Nanoparticle Mitigating Cytokine Storm by Scavenging Multiple Inflammatory Mediators of Sepsis.  ACS Nano,  17  (9): (8551–8563).  [PMID:37129445]
7. Yi Zhao, Yang Liu, Yuying Wang, Shulan Li, Yi Liu, Zhong Lin Wang, Peng Jiang.  (2023)  The process of free radical generation in contact electrification at solid-liquid interface.  Nano Energy,  112  (108464).  [PMID:]
8. Yizhong Shen, Xiang Gao, Huanhuan Chen, Yunlong Wei, Hui Yang, Ying Gu.  (2023)  Ultrathin C3N4 nanosheets-based oxidase-like 2D fluorescence nanozyme for dual-mode detection of organophosphorus pesticides.  JOURNAL OF HAZARDOUS MATERIALS,  451  (131171).  [PMID:36913745]
9. Xiaoyi Xie, Xiaofang Chen, Yaohui Wang, Maosen Zhang, Yuxiu Fan, Xiupei Yang.  (2023)  High-loading Cu single-atom nanozymes supported by carbon nitride with peroxidase-like activity for the colorimetric detection of tannic acid.  TALANTA,  257  (124387).  [PMID:36841014]
10. Na An, Yan Gao, Ying Shi, Xingxing Du, Jianing Cheng, Shuanglong Tang, Pengfei Liu, Huike Yang, Chongshen Guo.  (2023)  Nickel phosphide for MRI-guided synergistic photo-immunotherapy.  JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,  151  (150).  [PMID:]
11. Ji Ma, Yang Deng, Tingting Yang, Maoru Li, Jing Shang.  (2023)  Esculetin Alleviates Nonalcoholic Fatty Liver Disease on High-Cholesterol-Diet-Induced Larval Zebrafish and FFA-Induced BRL-3A Hepatocyte.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  24  (2): (1593).  [PMID:36675107]
12. Qingqing Liu, Chenchen Xu, Su Chu, Shuai Li, Fengxiang Wang, Yanmei Si, Guojiang Mao, Choufei Wu, Hua Wang.  (2022)  Covalent organic framework-loaded silver nanoparticles as robust mimetic oxidase for highly sensitive and selective colorimetric detection of mercury in blood.  Journal of Materials Chemistry B,  10  (48): (10075-10082).  [PMID:36458484]
13. Pinghua Ling, Pei Yang, Xianping Gao, Xinyu Sun, Feng Gao.  (2022)  ROS generation strategy based on biomimetic nanosheets by self-assembly of nanozymes.  Journal of Materials Chemistry B,  10  (46): (9607-9612).  [PMID:36112113]
14. Yecan Pan, Rui Weng, Linghao Zhang, Jing Qiu, Xinlu Wang, Guangqin Liao, Zhaohui Qin, Lingpu Zhang, Haihua Xiao, Yongzhong Qian, Xin Su.  (2022)  Simulation guided intramolecular orthogonal reporters for dissecting cellular oxidative stress and response.  Nano Today,  46  (101573).  [PMID:]
15. Chenghu Dai, Hao Jia, Wubin Wu, Baipeng Yin, Hong Wang, Ling Wang, Yeteng Zhong, Zihua Wang, Chuang Zhang, Jiannian Yao.  (2022)  Optically Triggering and Monitoring Single-Cell-Level Metabolism Using Ormosil-Decorated Ultrathin Fibers.  LANGMUIR,  38  (32): (9844–9852).  [PMID:35926220]
16. Hengrui Zhang, Wenya Jiang, Yaou Peng, Jie Yang, Xiaoying Chu, Ziyue Long, Renlong Li, Qiuwei Liang, Hao Suo, Shuting Wang, Mei Yang, Ji Qi, Dan Ding, Ying-Wei Yang, Bailiang Wang.  (2022)  Killing three birds with one stone: Near-infrared light triggered nitric oxide release for enhanced photodynamic and anti-inflammatory therapy in refractory keratitis.  BIOMATERIALS,  286  (121577).  [PMID:35617782]
17. Wei Lu, Shuhan Chen, Haifeng Zhang, Jiajun Qiu, Xuanyong Liu.  (2022)  FeNC single atom nanozymes with dual enzyme-mimicking activities for colorimetric detection of hydrogen peroxide and glutathione.  Journal of Materiomics,  8  (1251).  [PMID:]
18. Xiaoyu Huang, Wei Zhang, Yaowei Peng, Lu Gao, Fu Wang, Lan Wang, Xunbin Wei.  (2022)  A Multifunctional Layered Nickel Silicate Nanogenerator of Synchronous Oxygen Self-supply and Superoxide Radical Generation for Hypoxic Tumor Therapy.  ACS Nano,  16  (1): (974–983).  [PMID:34962763]
19. Huang Rui, Zhao Zizuo, Jiang Xujie, Li Weiwei, Zhang Lidan, Wang Bin, Tie Hongtao.  (2021)  Liposomal chrysin attenuates hepatic ischaemia-reperfusion injury: possible mechanism via inhibiting NLRP3 inflammasome.  JOURNAL OF PHARMACY AND PHARMACOLOGY,  74  (2): (216-226).  [PMID:34791354]

References

1. Tongsheng Huang, Xin Hu, Shiyu Huang, Dong Liu, Lihua Chen, Qinghua Wu, Weifeng Zhu, Xiaoyong Zhang, Meiying Liu, Yen Wei.  (2024)  One-step synthesis of cyclodextrin-based fluorescent hyperbranched polymer as type I photosensitizer for effective photodynamic therapy.  DYES AND PIGMENTS,  223  (111928).  [PMID:]
2. Lei Qian, Hu Xu, Ruqiang Yuan, Weijing Yun, Yufang Ma.  (2024)  Formononetin ameliorates isoproterenol induced cardiac fibrosis through improving mitochondrial dysfunction.  BIOMEDICINE & PHARMACOTHERAPY,  170  (116000).  [PMID:38070245]
3. Ping Ping, Shasha Guan, Chaoxue Ning, Ting Yang, Yali Zhao, Pei Zhang, Zhitao Gao, Shihui Fu.  (2023)  Fabrication of blended nanofibrous cardiac patch transplanted with TGF-β3 and human umbilical cord MSCs-derived exosomes for potential cardiac regeneration after acute myocardial infarction.  Nanomedicine-Nanotechnology Biology and Medicine,  54  (16): (102708).  [PMID:37788793]
4. Mengmeng Pan, Ming Wang, Linjiao Yang, Yongli Song, Ming Jiang, Xu Yu, Li Xu.  (2023)  Construction of Metal Organic Framework-Derived Fe-N-C Oxidase Nanozyme for Rapid and Sensitive Detection of Alkaline Phosphatase.  Nanomaterials,  13  (18): (2496).  [PMID:37764526]
5. Ke Xue, Yongfei Zhao, Saidong Sun, Yuanhang Li, Jiankang Liang, Zhengjian Qi.  (2023)  NIR-AIEgens nanospheres featuring high-fidelity dynamic lipid droplet targeting, expediting ferroptosis to annihilating tumor in hypoxia.  CHEMICAL ENGINEERING JOURNAL,  470  (144125).  [PMID:]
6. Zhen Li, Yuanji Feng, Sijia Zhang, Tong Li, Huixin Li, Dianwei Wang, Kai Hao, Chaoliang He, Huayu Tian, Xuesi Chen.  (2023)  A Multifunctional Nanoparticle Mitigating Cytokine Storm by Scavenging Multiple Inflammatory Mediators of Sepsis.  ACS Nano,  17  (9): (8551–8563).  [PMID:37129445]
7. Yi Zhao, Yang Liu, Yuying Wang, Shulan Li, Yi Liu, Zhong Lin Wang, Peng Jiang.  (2023)  The process of free radical generation in contact electrification at solid-liquid interface.  Nano Energy,  112  (108464).  [PMID:]
8. Yizhong Shen, Xiang Gao, Huanhuan Chen, Yunlong Wei, Hui Yang, Ying Gu.  (2023)  Ultrathin C3N4 nanosheets-based oxidase-like 2D fluorescence nanozyme for dual-mode detection of organophosphorus pesticides.  JOURNAL OF HAZARDOUS MATERIALS,  451  (131171).  [PMID:36913745]
9. Xiaoyi Xie, Xiaofang Chen, Yaohui Wang, Maosen Zhang, Yuxiu Fan, Xiupei Yang.  (2023)  High-loading Cu single-atom nanozymes supported by carbon nitride with peroxidase-like activity for the colorimetric detection of tannic acid.  TALANTA,  257  (124387).  [PMID:36841014]
10. Na An, Yan Gao, Ying Shi, Xingxing Du, Jianing Cheng, Shuanglong Tang, Pengfei Liu, Huike Yang, Chongshen Guo.  (2023)  Nickel phosphide for MRI-guided synergistic photo-immunotherapy.  JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,  151  (150).  [PMID:]
11. Ji Ma, Yang Deng, Tingting Yang, Maoru Li, Jing Shang.  (2023)  Esculetin Alleviates Nonalcoholic Fatty Liver Disease on High-Cholesterol-Diet-Induced Larval Zebrafish and FFA-Induced BRL-3A Hepatocyte.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  24  (2): (1593).  [PMID:36675107]
12. Qingqing Liu, Chenchen Xu, Su Chu, Shuai Li, Fengxiang Wang, Yanmei Si, Guojiang Mao, Choufei Wu, Hua Wang.  (2022)  Covalent organic framework-loaded silver nanoparticles as robust mimetic oxidase for highly sensitive and selective colorimetric detection of mercury in blood.  Journal of Materials Chemistry B,  10  (48): (10075-10082).  [PMID:36458484]
13. Pinghua Ling, Pei Yang, Xianping Gao, Xinyu Sun, Feng Gao.  (2022)  ROS generation strategy based on biomimetic nanosheets by self-assembly of nanozymes.  Journal of Materials Chemistry B,  10  (46): (9607-9612).  [PMID:36112113]
14. Yecan Pan, Rui Weng, Linghao Zhang, Jing Qiu, Xinlu Wang, Guangqin Liao, Zhaohui Qin, Lingpu Zhang, Haihua Xiao, Yongzhong Qian, Xin Su.  (2022)  Simulation guided intramolecular orthogonal reporters for dissecting cellular oxidative stress and response.  Nano Today,  46  (101573).  [PMID:]
15. Chenghu Dai, Hao Jia, Wubin Wu, Baipeng Yin, Hong Wang, Ling Wang, Yeteng Zhong, Zihua Wang, Chuang Zhang, Jiannian Yao.  (2022)  Optically Triggering and Monitoring Single-Cell-Level Metabolism Using Ormosil-Decorated Ultrathin Fibers.  LANGMUIR,  38  (32): (9844–9852).  [PMID:35926220]
16. Hengrui Zhang, Wenya Jiang, Yaou Peng, Jie Yang, Xiaoying Chu, Ziyue Long, Renlong Li, Qiuwei Liang, Hao Suo, Shuting Wang, Mei Yang, Ji Qi, Dan Ding, Ying-Wei Yang, Bailiang Wang.  (2022)  Killing three birds with one stone: Near-infrared light triggered nitric oxide release for enhanced photodynamic and anti-inflammatory therapy in refractory keratitis.  BIOMATERIALS,  286  (121577).  [PMID:35617782]
17. Wei Lu, Shuhan Chen, Haifeng Zhang, Jiajun Qiu, Xuanyong Liu.  (2022)  FeNC single atom nanozymes with dual enzyme-mimicking activities for colorimetric detection of hydrogen peroxide and glutathione.  Journal of Materiomics,  8  (1251).  [PMID:]
18. Xiaoyu Huang, Wei Zhang, Yaowei Peng, Lu Gao, Fu Wang, Lan Wang, Xunbin Wei.  (2022)  A Multifunctional Layered Nickel Silicate Nanogenerator of Synchronous Oxygen Self-supply and Superoxide Radical Generation for Hypoxic Tumor Therapy.  ACS Nano,  16  (1): (974–983).  [PMID:34962763]
19. Huang Rui, Zhao Zizuo, Jiang Xujie, Li Weiwei, Zhang Lidan, Wang Bin, Tie Hongtao.  (2021)  Liposomal chrysin attenuates hepatic ischaemia-reperfusion injury: possible mechanism via inhibiting NLRP3 inflammasome.  JOURNAL OF PHARMACY AND PHARMACOLOGY,  74  (2): (216-226).  [PMID:34791354]

Solution Calculators

Privacy Policy Website Terms of Use Return policy Terms and Conditions of Sale Cookie Policy Sales Policy
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Copyright © 2023-present Aladdin Scientific Corp . All rights reserved.