Dihydromyricetin - 10mM in DMSO, high purity , CAS No.27200-12-0(DMSO)

Item Number

D408827

• Synonyms: Ampeloptin;(2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one
• Specifications & Purity: 10mM in DMSO
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads

Product Description

Information

Dihydromyricetin (Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata.
In vitro

Dihydromyricetin shows antioxidant activity as an effective scavenger of 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). It also inhibits the increase of lipid peroxidation (LPO) values in linolei acid system catalyzed by FeSO₄-edetic acid. DHM (1 μM) as a novel anti-alcohol intoxication medication antagonizes both acute EtOH-induced potentiation of GABA(A)Rs and EtOH exposure/withdrawal-induced GABA(A)R plasticity and increases in GABA(A)R alpha4 subunit expression in hippocampus and cultured neurons.

In vivo

Dihydromyricetin (1 mg/kg, i.p.) counteracts acute alcohol (EtOH) intoxication, and also withdrawals signs in rats including tolerance, increased anxiety, and seizure susceptibity. LD50: Mice 1.41g/kg (i.p.)
Cell Data

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Incubation Time：

Powder Purity:≥99%