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Dihydrotanshinone I - ≥98% (HPLC), high purity , CAS No.87205-99-0

  • ≥98%(HPLC)
Item Number
D139369
Grouped product items
SKUSizeAvailabilityPrice Qty
D139369-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$117.90
D139369-20mg
20mg
In stock
$212.90
D139369-50mg
50mg
In stock
$367.90

Potent cytotoxic agent

View related series
Terpenoids

Basic Description

SynonymsDihydrotanshinone I|87205-99-0|15,16-dihydrotanshinone I|DihydrotanshinoneI|(-)-Dihydrotanshinone I|Dihydrotanshinone-I|Tanshinone I, dihydro-|HSDB 8105|UNII-562G9360V6|562G9360V6|DTXSID20236187|(1R)-1,6-dimethyl-1,2-dihydronaphtho[1,2-g][1]benzofuran-10,
Specifications & Purity≥98%(HPLC)
Biochemical and Physiological MechanismsPotent cytotoxic agent (IC 50 = 4.6 μM). Suppresses endothelial cell proliferation, migration, invasion and tube formation. Induces apoptosis of prostate cancer cells via induction of ER stress and/or inhibition of proteasome activity.
Storage TempStore at 2-8°C
Shipped InWet ice
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets

ELAVL1 Tchem ELAV-like protein 1 3 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CES1 Tchem Liver carboxylesterase 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CES2 Tchem Cocaine esterase 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTPN11 Tchem Tyrosine-protein phosphatase non-receptor type 11 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PTPN6 Tchem Tyrosine-protein phosphatase non-receptor type 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

VDR Tclin Vitamin D3 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HIF1A Tchem Hypoxia-inducible factor 1-alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

POLK Tbio DNA polymerase kappa 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KDM1A Tchem Lysine-specific histone demethylase 1A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPK12 Tchem Mitogen-activated protein kinase 12 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ACHE Tclin Acetylcholinesterase 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AKR1B1 Tclin Aldose reductase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BCHE Tclin Cholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (1R)-1,6-dimethyl-1,2-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione
INCHI InChI=1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1
InChi Key HARGZZNYNSYSGJ-JTQLQIEISA-N
Canonical SMILES CC1COC2=C1C(=O)C(=O)C3=C2C=CC4=C(C=CC=C43)C
Isomeric SMILES C[C@H]1COC2=C1C(=O)C(=O)C3=C2C=CC4=C(C=CC=C43)C
WGK Germany 3
PubChem CID 11425923
Molecular Weight 278.3

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

5 results found

Lot NumberCertificate TypeDateItem
K2117099Certificate of AnalysisSep 14, 2023 D139369
K2117100Certificate of AnalysisSep 14, 2023 D139369
K2117249Certificate of AnalysisSep 14, 2023 D139369
K1904073Certificate of AnalysisJun 08, 2023 D139369
E2128430Certificate of AnalysisMar 10, 2023 D139369

Chemical and Physical Properties

SensitivityLight Sensitive
Melt Point(°C)216 °C

Safety and Hazards(GHS)

Pictogram(s) GHS09,   GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

H400:Very toxic to aquatic life

Precautionary Statements

P273:Avoid release to the environment.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P391:Collect spillage.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

WGK Germany 3

Related Documents

Solution Calculators