Skip to the beginning of the images gallery

Dihydrotanshinone I - 10mM in DMSO, high purity , CAS No.87205-99-0

10mM in DMSO

CAS#: 87205-99-0
Formula: C₁₈H₁₄O₃
Molecular Weight: 278.3
PubChem CID: 11425923

Item Number

D426589

Grouped product items
SKU	Size	Availability	Price	Qty
D426589-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$167.90

Potent cytotoxic agent

Basic Description

Synonyms	Dihydrotanshinone I\|87205-99-0\|15,16-dihydrotanshinone I\|DihydrotanshinoneI\|(-)-Dihydrotanshinone I\|Dihydrotanshinone-I\|Tanshinone I, dihydro-\|HSDB 8105\|UNII-562G9360V6\|562G9360V6\|DTXSID20236187\|(1R)-1,6-dimethyl-1,2-dihydronaphtho[1,2-g][1]benzofuran-10,
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Potent cytotoxic agent (IC 50 = 4.6 μM). Suppresses endothelial cell proliferation, migration, invasion and tube formation. Induces apoptosis of prostate cancer cells via induction of ER stress and/or inhibition of proteasome activity.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets

ELAVL1 Tchem ELAV-like protein 1 3 Activities

Discover Target: ELAVL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CES1 Tchem Liver carboxylesterase 1 1 Activities

Discover Target: CES1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CES2 Tchem Cocaine esterase 1 Activities

Discover Target: CES2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN11 Tchem Tyrosine-protein phosphatase non-receptor type 11 0 Activities

Discover Target: PTPN11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTPN6 Tchem Tyrosine-protein phosphatase non-receptor type 6 0 Activities

Discover Target: PTPN6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

VDR Tclin Vitamin D3 receptor 0 Activities

Discover Target: VDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HIF1A Tchem Hypoxia-inducible factor 1-alpha 0 Activities

Discover Target: HIF1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Discover Target: KMT2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

Discover Target: SLCO1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Discover Target: SLCO1B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLK Tbio DNA polymerase kappa 0 Activities

Discover Target: POLK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM1A Tchem Lysine-specific histone demethylase 1A 0 Activities

Discover Target: KDM1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK12 Tchem Mitogen-activated protein kinase 12 0 Activities

Discover Target: MAPK12

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACHE Tclin Acetylcholinesterase 2 Activities

Discover Target: ACHE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKR1B1 Tclin Aldose reductase 0 Activities

Discover Target: AKR1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BCHE Tclin Cholinesterase 0 Activities

Discover Target: BCHE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(1R)-1,6-dimethyl-1,2-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione
INCHI	InChI=1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1
InChi Key	HARGZZNYNSYSGJ-JTQLQIEISA-N
Canonical SMILES	CC1COC2=C1C(=O)C(=O)C3=C2C=CC4=C(C=CC=C43)C
Isomeric SMILES	C[C@H]1COC2=C1C(=O)C(=O)C3=C2C=CC4=C(C=CC=C43)C
WGK Germany	3
PubChem CID	11425923
Molecular Weight	278.3

Sensitivity

Light Sensitive

Melt Point(°C)

216 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H400:Very toxic to aquatic life
Precautionary Statements	P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.