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Dimethylfraxetin - 99%, high purity , CAS No.6035-49-0

≥99%

CAS#: 6035-49-0
Formula: C₁₂H₁₂O₅
Molecular Weight: 236.22
PubChem CID: 3083928

Item Number

D646737

Grouped product items
SKU	Size	Availability	Price
D646737-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$74.90
D646737-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$156.90
D646737-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$276.90
D646737-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$552.90

Phenylpropanoids Coumarins

View related series

Carbonic Anhydrase Metabolic Enzyme/Protease Phenylpropanoids Coumarins

Basic Description

Synonyms	Dimethylfraxetin\|6,7,8-Trimethoxycoumarin\|6035-49-0\|Fraxidin Methyl Ether\|6,7,8-trimethoxychromen-2-one\|Fraxetin dimethyl ether\|6,7,8,-trimethoxycoumarin\|CHEMBL253551\|6,7,8-Trimethoxy-2H-chromen-2-one\|6,7,8-Trimethoxycoumarin;Fraxetin dimethyl ether\|Di-O-
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Dimethylfraxetin is a Carbonic anhydrase inhibitor, with a K i value of 0.0097 μM.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Dimethylfraxetin is a Carbonic anhydrase inhibitor, with a K i value of 0.0097 μM. In Vitro At CA I there is one stand out compound being Dimethylfraxetin (compound 17), a nanomolar CA I inhibitor. This trimethoxy coumarin is the most potent of any of the NP coumarins across the six CA isozymes of the present study. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Ki: 0.0097 μM (Carbonic anhydrase)

Associated Targets

HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 0 Activities

Discover Target: HSD17B10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA13 Tclin Carbonic anhydrase 13 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA1 Tclin Carbonic anhydrase 1 1 Activities

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CA2 Tclin Carbonic anhydrase 2 0 Activities

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CA12 Tclin Carbonic anhydrase 12 0 Activities

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CA9 Tclin Carbonic anhydrase 9 0 Activities

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CA7 Tclin Carbonic anhydrase 7 0 Activities

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ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

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KDM4E Tchem Lysine-specific demethylase 4E 0 Activities

Discover Target: KDM4E

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	6,7,8-trimethoxychromen-2-one
INCHI	InChI=1S/C12H12O5/c1-14-8-6-7-4-5-9(13)17-10(7)12(16-3)11(8)15-2/h4-6H,1-3H3
InChi Key	RAYQKHLZHPFYEJ-UHFFFAOYSA-N
Canonical SMILES	COC1=C(C(=C2C(=C1)C=CC(=O)O2)OC)OC
Isomeric SMILES	COC1=C(C(=C2C(=C1)C=CC(=O)O2)OC)OC
PubChem CID	3083928
Molecular Weight	236.22

Solubility

DMSO : 125 mg/mL (529.17 mM; Need ultrasonic and warming)

Flash Point(°F)

Not applicable

Flash Point(°C)

Not applicable

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell.

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