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D110644-100ml

100ml

Available within 4-8 weeks(?)

$21.90

D110644-500ml

500ml

Available within 4-8 weeks(?)

$55.90

D110644-100g

100g

Available within 8-12 weeks(?)

$19.90

D110644-500g

500g

Available within 8-12 weeks(?)

$51.90

Basic Description

Synonyms	DIPHENYL ETHER\|Diphenyl oxide\|101-84-8\|Phenyl ether\|Phenoxybenzene\|Oxydibenzene\|Benzene, 1,1'-oxybis-\|Phenyl oxide\|Oxybisbenzene\|1,1'-oxydibenzene\|Biphenyl oxide\|Diphenylether\|Oxydiphenyl\|Geranium crystals\|Ether, diphenyl-\|Chemcryl JK-EB\|Benzene, phenoxy-
Specifications & Purity	≥99%(GC)
Storage Temp	Desiccated
Shipped In	Normal
Product Description	The diphenyl derivatives, having potency for inhibiting InhA (an essential enoyl acyl carrier protein reductase involved in mycolic acid biosynthesis), were studied. Diphenyl ether may be used to synthesize dibenzofuran via intramolecular cyclization in the presence of palladium acetate.

Associated Targets

TSHR Tclin Thyrotropin receptor 0 Activities

Discover Target: TSHR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LTA4H Tchem Leukotriene A-4 hydrolase 0 Activities

Discover Target: LTA4H

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR1H4 Tclin Bile acid receptor 0 Activities

Discover Target: NR1H4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

Discover Target: APEX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Discover Target: NFE2L2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	phenoxybenzene
INCHI	InChI=1S/C12H10O/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h1-10H
InChi Key	USIUVYZYUHIAEV-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)OC2=CC=CC=C2
Isomeric SMILES	C1=CC=C(C=C1)OC2=CC=CC=C2
WGK Germany	2
RTECS	KN8970000
PubChem CID	7583
UN Number	3077(international)
Packing Group	III
Molecular Weight	170.21
Beilstein	1364620

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

11 results found

Lot Number	Certificate Type	Date	Item
H2406242	Certificate of Analysis	Apr 15, 2024	D110644
H2406240	Certificate of Analysis	Apr 15, 2024	D110644
H2406241	Certificate of Analysis	Apr 15, 2024	D110644
C2331024	Certificate of Analysis	Oct 24, 2022	D110644
J2227040	Certificate of Analysis	Oct 24, 2022	D110644
J2227046	Certificate of Analysis	Oct 24, 2022	D110644
J2227078	Certificate of Analysis	Oct 24, 2022	D110644
A2220399	Certificate of Analysis	Jan 07, 2022	D110644
C2415144	Certificate of Analysis	Sep 07, 2021	D110644
G2403042	Certificate of Analysis	Sep 07, 2021	D110644
I2118173	Certificate of Analysis	Sep 07, 2021	D110644

Chemical and Physical Properties

Solubility	Soluble in alcohol, chloroform, ethyl acetate, benzene, diethyl ether and glacial acetic acid. Insoluble in water.
Freezing Point(°C)	27 °C
Refractive Index	1.579
Flash Point(°F)	115℃
Flash Point(°C)	115℃
Boil Point(°C)	258°C
Melt Point(°C)	27°C

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H319:Causes serious eye irritation H411:Toxic to aquatic life with long lasting effects
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P391:Collect spillage. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help.
WGK Germany	2
RTECS	KN8970000
Class	9
Merck Index	7288

References

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3. Hua Xu,Todd J Sullivan,Jun-ichiro Sekiguchi,Teruo Kirikae,Iwao Ojima,Christopher F Stratton,Weimin Mao,Fernando L Rock,M R K Alley,Francis Johnson,Stephen G Walker,Peter J Tonge. (2008-03-14) Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus.. Biochemistry, 47 ((14)): (4228-4236). [PMID:18335995]
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8. Manfred Pöhlein,Raquel Urpi Bertran,Marion Wolf,Rudi van Eldik. (2008-08-09) Versatile and fast gas chromatographic determination of frequently used brominated flame retardants in styrenic polymers.. Journal of chromatography. A, 1203 ((2)): (217-228). [PMID:18687441]
9. Xiaolu Jiang,Lu Zhou,Dengguo Wei,Hu Meng,Ying Liu,Luhua Lai. (2008-10-28) Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives.. Bioorganic & medicinal chemistry letters, 18 ((24)): (6549-6552). [PMID:18952425]
10. Fan Liu,Qing Li,Hong Yang,Xiao-Ling Cai,Xue-Kui Xia,Sheng-Ping Chen,Meng-Feng Li,Zhi-Gang She,Yong-Cheng Lin. (2009-02-04) Structure elucidation of three diphenyl ether derivatives from the mangrove endophytic fungus SBE-14 from the South China Sea.. Magnetic resonance in chemistry : MRC, 47 ((5)): (453-455). [PMID:19189281]
11. Ariana Beste,A C Buchanan. (2009-03-06) Computational study of bond dissociation enthalpies for lignin model compounds. Substituent effects in phenethyl phenyl ethers.. The Journal of organic chemistry, 74 ((7)): (2837-2841). [PMID:19260664]
12. Denys Meshcheryakov,Michael Bolte,Volker Böhmer. (2009-10-16) Macrocyclic oligoureas with xanthene and diphenyl ether units.. Organic & biomolecular chemistry, 7 ((21)): (4386-4390). [PMID:19830287]
13. Wataru Watanabe,Tomomi Shimizu,Rie Sawamura,Akane Hino,Katsuhiko Konno,Masahiko Kurokawa. (2010-04-27) Functional disorder of primary immunity responding to respiratory syncytial virus infection in offspring mice exposed to a flame retardant, decabrominated diphenyl ether, perinatally.. Journal of medical virology, 82 ((6)): (1075-1082). [PMID:20419825]
14. Kostantinos Benekos,Christos Kissoudis,Irini Nianiou-Obeidat,Nikolaos Labrou,Panagiotis Madesis,Mary Kalamaki,Antonis Makris,Athanasios Tsaftaris. (2010-07-20) Overexpression of a specific soybean GmGSTU4 isoenzyme improves diphenyl ether and chloroacetanilide herbicide tolerance of transgenic tobacco plants.. Journal of biotechnology, 150 ((1)): (195-201). [PMID:20638428]
15. Margaret J Smith,Götz Bucher. (2010-09-16) Quenching of triplet benzophenone by benzene and diphenyl ether: a DFT study.. The journal of physical chemistry. A, 114 ((39)): (10712-10716). [PMID:20839816]
16. Ge-Fei Hao,Ying Tan,Ning-Xi Yu,Guang-Fu Yang. (2011-01-25) Structure-activity relationships of diphenyl-ether as protoporphyrinogen oxidase inhibitors: insights from computational simulations.. Journal of computer-aided molecular design, 25 ((3)): (213-222). [PMID:21259066]
17. Takayuki Yonezawa,Ji-Won Lee,Hiroyuki Akazawa,Masahiko Inagaki,Byung-Yoon Cha,Kazuo Nagai,Kazumi Yagasaki,Toshihiro Akihisa,Je-Tae Woo. (2011-05-10) Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense.. Bioorganic & medicinal chemistry letters, 21 ((11)): (3248-3251). [PMID:21550801]
18. Julia Frant,Ainelly Veerendhar,Tamir Chernilovsky,Shlomo Nedvetzki,Olga Vaksman,Amnon Hoffman,Eli Breuer,Reuven Reich. (2011-06-10) Orally active, antimetastatic, nontoxic diphenyl ether-derived carbamoylphosphonate matrix metalloproteinase inhibitors.. ChemMedChem, 6 ((8)): (1471-1477). [PMID:21656908]
19. Sindra L Summoogum,John C Mackie,Eric M Kennedy,Michael A Delichatsios,Bogdan Z Dlugogorski. (2011-07-09) Formation of toxic species and precursors of PCDD/F in thermal decomposition of alpha-cypermethrin.. Chemosphere, 85 ((2)): (143-150). [PMID:21737117]
20. Haibo Yu,Huibin Yang,Dongliang Cui,Liang Lv,Bin Li. (2011-10-01) Synthesis and herbicidal activity of diphenyl ether derivatives containing unsaturated carboxylates.. Journal of agricultural and food chemistry, 59 ((21)): (11718-11726). [PMID:21958315]
21. Yinghong Yang,Zhenling Wang,Jianzhong Yang,Tao Yang,Weiyi Pi,Wei Ang,Yanni Lin,Yuanyuan Liu,Zicheng Li,Youfu Luo,Yuquan Wei. (2011-12-27) Design, synthesis and evaluation of novel molecules with a diphenyl ether nucleus as potential antitubercular agents.. Bioorganic & medicinal chemistry letters, 22 ((2)): (954-957). [PMID:22197389]
22. Xingyu Wang,Roberto Rinaldi. (2012-05-03) Solvent effects on the hydrogenolysis of diphenyl ether with Raney nickel and their implications for the conversion of lignin.. ChemSusChem, 5 ((8)): (1455-1466). [PMID:22549827]
23. Do Gyun Lee,Fuman Zhao,Yohannes H Rezenom,David H Russell,Kung-Hui Chu. (2012-06-08) Biodegradation of triclosan by a wastewater microorganism.. Water research, 46 ((13)): (4226-4234). [PMID:22673343]
24. Jiaqi Shi,Mingbao Feng,Xuesheng Zhang,Zhongbo Wei,Zunyao Wang. (2013-04-03) Acute oral toxicity and liver oxidant/antioxidant stress of halogenated benzene, phenol, and diphenyl ether in mice: a comparative and mechanism exploration.. Environmental science and pollution research international, 20 ((9)): (6138-6149). [PMID:23546852]
25. Albert Serrà,Elvira Gómez,José Francisco López-Barbera,Josep Nogués,Elisa Vallés. (2014-05-03) Green electrochemical template synthesis of CoPt nanoparticles with tunable size, composition, and magnetism from microemulsions using an ionic liquid (bmimPF6).. ACS nano, 8 ((5)): (4630-4639). [PMID:24786899]
26. Sedat Dogan,Thomas Bielewicz,Vera Lebedeva,Christian Klinke. (2015-02-13) Photovoltaic effect in individual asymmetrically contacted lead sulfide nanosheets.. Nanoscale, 7 ((11)): (4875-4883). [PMID:25673356]
27. Mei Wang,Huili Wang,Rongbo Zhang,Meiping Ma,Kun Mei,Fang Fang,Xuedong Wang. (2015-08-15) Photolysis of Low-Brominated Diphenyl Ethers and Their Reactive Oxygen Species-Related Reaction Mechanisms in an Aqueous System.. PloS one, 10 ((8)): (e0135400-e0135400). [PMID:26274605]
28. Oriol Penon,María J Marín,David B Amabilino,David A Russell,Lluïsa Pérez-García. (2015-10-12) Iron oxide nanoparticles functionalized with novel hydrophobic and hydrophilic porphyrins as potential agents for photodynamic therapy.. Journal of colloid and interface science, 462 (154-165). [PMID:26454374]
29. Boqu Yu,Ruirui Zhang,Pengyan Liu,Yajing Zhang,Yanna Zhang,Yang Bai. (2015-10-12) Determination of nine hydroxylated polybrominated diphenyl ethers in water by precolumn derivatization-gas chromatography-mass spectrometry.. Journal of chromatography. A, 1419 (19-25). [PMID:26454789]
30. Xiaolu Jiang,Lu Zhou,Yiran Wu,Dengguo Wei,Chunyi Sun,Jia Jia,Ying Liu,Luhua Lai. (2010-05-01) Modulating the substrate specificity of LTA4H aminopeptidase by using chemical compounds and small-molecule-guided mutagenesis.. Chembiochem : a European journal of chemical biology, 11 ((8)): (1120-1128). [PMID:20432426]
31. Alexey G Sergeev,John F Hartwig. (2011-04-23) Selective, nickel-catalyzed hydrogenolysis of aryl ethers.. Science (New York, N.Y.), 332 ((6028)): (439-443). [PMID:21512027]
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33. Bruno F B Silva,Miguel Zepeda-Rosales,Neeraja Venkateswaran,Bretton J Fletcher,Lester G Carter,Tsutomu Matsui,Thomas M Weiss,Jun Han,Youli Li,Ulf Olsson,Cyrus R Safinya. (2014-11-15) Nematic director reorientation at solid and liquid interfaces under flow: SAXS studies in a microfluidic device.. Langmuir : the ACS journal of surfaces and colloids, 31 ((14)): (4361-4371). [PMID:25396748]
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Diphenyl ether - >99.0%(GC), high purity , CAS No.101-84-8