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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D127049-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $119.90 | |
D127049-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $378.90 | |
D127049-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $521.90 | |
D127049-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,174.90 |
Synonyms | Dipraglurant|872363-17-2|ADX48621|Dipraglurant [INN]|ADX-48621|6-Fluoro-2-[4-(pyridin-2-yl)-3-butynyl]imidazo[1,2-a]pyridine|CV8JZR21A1|CHEMBL2346738|6-Fluoro-2-(4-(pyridin-2-yl)but-3-yn-1-yl)imidazo(1,2-a)pyridine|6-fluoro-2-(4-pyridin-2-ylbut-3-ynyl)imi |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Dipraglurant (ADX 48621) is mGlu5 receptor negative allosteric modulator. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR, MODULATOR |
Mechanism of action | Metabotropic glutamate receptor 5 modulator |
Product Description | Dipraglurant is a negative allosteric regulator (NAM) of blood-brain barrier transmissible mGluR5 with effective, selective and oral activity, with an IC50 value of 21 nM. Dipraglurant can treat levodopa-induced dyskinesia in Parkinson's disease (PD-LID). |
ALogP | 3.5 |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 6-fluoro-2-(4-pyridin-2-ylbut-3-ynyl)imidazo[1,2-a]pyridine |
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INCHI | InChI=1S/C16H12FN3/c17-13-8-9-16-19-15(12-20(16)11-13)7-2-1-5-14-6-3-4-10-18-14/h3-4,6,8-12H,2,7H2 |
InChi Key | LZXMUJCJAWVHPZ-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=NC(=C1)C#CCCC2=CN3C=C(C=CC3=N2)F |
Isomeric SMILES | C1=CC=NC(=C1)C#CCCC2=CN3C=C(C=CC3=N2)F |
PubChem CID | 44557636 |
Molecular Weight | 265.29 |
CAS Registry No. | 872363-17-2 |
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PubChem CID | 44557636 |
ChEMBL Ligand | CHEMBL2346738 |
Wikipedia | Dipraglurant |
GPCRdb Ligand | dipraglurant |
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Solubility | DMSO |
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