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Dipraglurant - ≥98%, high purity , Metabotropic glutamate receptor 5 modulator, CAS No.872363-17-2, Metabotropic glutamate receptor 5 modulator

  • Moligand™
  • ≥98%
Item Number
D127049
Grouped product items
SKUSizeAvailabilityPrice Qty
D127049-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$119.90
D127049-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$378.90
D127049-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$521.90
D127049-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,174.90

Basic Description

SynonymsDipraglurant|872363-17-2|ADX48621|Dipraglurant [INN]|ADX-48621|6-Fluoro-2-[4-(pyridin-2-yl)-3-butynyl]imidazo[1,2-a]pyridine|CV8JZR21A1|CHEMBL2346738|6-Fluoro-2-(4-(pyridin-2-yl)but-3-yn-1-yl)imidazo(1,2-a)pyridine|6-fluoro-2-(4-pyridin-2-ylbut-3-ynyl)imi
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological Mechanisms

Dipraglurant (ADX 48621) is mGlu5 receptor negative allosteric modulator.

Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeALLOSTERIC MODULATOR, MODULATOR
Mechanism of actionMetabotropic glutamate receptor 5 modulator
Product Description

Dipraglurant is a negative allosteric regulator (NAM) of blood-brain barrier transmissible mGluR5 with effective, selective and oral activity, with an IC50 value of 21 nM. Dipraglurant can treat levodopa-induced dyskinesia in Parkinson's disease (PD-LID).

Product Properties

ALogP3.5

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRM5 Tchem Metabotropic glutamate receptor 5 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 6-fluoro-2-(4-pyridin-2-ylbut-3-ynyl)imidazo[1,2-a]pyridine
INCHI InChI=1S/C16H12FN3/c17-13-8-9-16-19-15(12-20(16)11-13)7-2-1-5-14-6-3-4-10-18-14/h3-4,6,8-12H,2,7H2
InChi Key LZXMUJCJAWVHPZ-UHFFFAOYSA-N
Canonical SMILES C1=CC=NC(=C1)C#CCCC2=CN3C=C(C=CC3=N2)F
Isomeric SMILES C1=CC=NC(=C1)C#CCCC2=CN3C=C(C=CC3=N2)F
PubChem CID 44557636
Molecular Weight 265.29

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilityDMSO

Related Documents

Solution Calculators