DKFZ-748 - ≥98.0%, high purity , CAS No.2490709-68-5

Item Number

D649897

Grouped product items
SKU	Size	Availability	Price
D649897-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$250.90
D649897-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$400.90
D649897-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$780.90
D649897-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,240.90

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Basic Description

Specifications & Purity	≥98.0%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Product Description	DKFZ-748 is a selective HDAC10 inhibitor ( pIC 50 =7.66), and shows anti-tumor activity. In Vitro DKFZ-748 shows dose-dependent growth inhibition of HeLa cells in a polyamine-limiting in vitro tumor model. DKFZ-748 (1-100 μM; 72 h) induces HDAC acetylation of BE(2)-C cells. DKFZ 748 shows significant accumulation of N8 acetyl- and N1,8-diacetylspermidine in a dose-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: BE(2)-C cells Concentration: 1, 10, 100 μM Incubation Time: 72 h Result: Induced significant HDAC acetylation only at the highest tested concentration (100 μM). Form:Solid

Canonical SMILES

O=C(NCCN(CCCC(NO)=O)C)C1=C2C=CC=CC2=CC=C1

Molecular Weight

329.39

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Basic Description