| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| D133969-250mg | 250mg | In stock | $59.90 | |
| D133969-1g | 1g | In stock | $171.90 | |
| D133969-5g | 5g | In stock | $685.90 |
| Synonyms | PAG | 2WA8F50C3F | 4-PENTYNOIC ACID, 2-AMINO-, (+/-)- | FT-0698061 | Ftc, dl- | H-Propargyl-DL-Gly-OH;(RS)-2-Amino-4-pentynoic acid | 2-amino-4-pentynoic acid, monohydrochloride | AB89124 | 2-Propynylglycine | Propargyl glycine | FU67PLJ48R | AS-18031 | D |
|---|---|
| Specifications & Purity | ≥98% |
| Biochemical and Physiological Mechanisms | DL-Propargylglycine (PAG) is an irreversible inhibitor of the enzyme cystathionine γ-lyase (GCL), a key enzyme involved in glutathione synthesis and the metabolic transsulfuration pathway which regulates homocysteine concentration and mediates cysteine sy |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| Pubchem Sid | 488186922 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488186922 |
| IUPAC Name | 2-aminopent-4-ynoic acid |
| INCHI | InChI=1S/C5H7NO2/c1-2-3-4(6)5(7)8/h1,4H,3,6H2,(H,7,8) |
| InChi Key | DGYHPLMPMRKMPD-UHFFFAOYSA-N |
| Canonical SMILES | C#CCC(C(=O)O)N |
| Isomeric SMILES | C#CCC(C(=O)O)N |
| WGK Germany | 3 |
| PubChem CID | 95575 |
| Molecular Weight | 113.11 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 K2112399 | Certificate of Analysis | Aug 04, 2023 | D133969 |
| K2112424 | Certificate of Analysis | Aug 04, 2023 | D133969 |
| F2305192 | Certificate of Analysis | May 13, 2023 | D133969 |
| F2305195 | Certificate of Analysis | May 13, 2023 | D133969 |
| F2305196 | Certificate of Analysis | May 13, 2023 | D133969 |
| F2305199 | Certificate of Analysis | May 13, 2023 | D133969 |
| F2305200 | Certificate of Analysis | May 13, 2023 | D133969 |
| F2305203 | Certificate of Analysis | May 13, 2023 | D133969 |
| B2314423 | Certificate of Analysis | Feb 20, 2023 | D133969 |
| L2010024 | Certificate of Analysis | Sep 20, 2022 | D133969 |
| L1626011 | Certificate of Analysis | Jan 25, 2022 | D133969 |
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
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| 1. Fu Shaodong, Wang Zhenglei, Han Xiangan, Xu Yuanyuan, Miao Jinfeng. (2023) The therapeutic potential for targeting CSE/H2S signaling in macrophages against Escherichia coli infection. VETERINARY RESEARCH, 54 (1): (1-12). [PMID:37644526] [10.1186/s13567-023-01203-8] |
| 2. Jia Honglei, Chen Sisi, Liu Dan, Liesche Johannes, Shi Cong, Wang Juan, Ren Meijuan, Wang Xiaofeng, Yang Jun, Shi Wei, Li Jisheng. (2018) Ethylene-Induced Hydrogen Sulfide Negatively Regulates Ethylene Biosynthesis by Persulfidation of ACO in Tomato Under Osmotic Stress. Frontiers in Plant Science, 9 [PMID:30386366] [10.3389/fpls.2018.01517] |
| 1. Fu Shaodong, Wang Zhenglei, Han Xiangan, Xu Yuanyuan, Miao Jinfeng. (2023) The therapeutic potential for targeting CSE/H2S signaling in macrophages against Escherichia coli infection. VETERINARY RESEARCH, 54 (1): (1-12). [PMID:37644526] [10.1186/s13567-023-01203-8] |
| 2. Jia Honglei, Chen Sisi, Liu Dan, Liesche Johannes, Shi Cong, Wang Juan, Ren Meijuan, Wang Xiaofeng, Yang Jun, Shi Wei, Li Jisheng. (2018) Ethylene-Induced Hydrogen Sulfide Negatively Regulates Ethylene Biosynthesis by Persulfidation of ACO in Tomato Under Osmotic Stress. Frontiers in Plant Science, 9 [PMID:30386366] [10.3389/fpls.2018.01517] |
