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Home Neuroscience Neurology process Neural Signal Transduction DL-TBOA - ≥98%(HPLC), high purity , CAS No.205309-81-5, Inhibitor of Excitatory amino acid transporter 1;Inhibitor of Excitatory amino acid transporter 2;Inhibitor of Excitatory amino acid transporter 3;Inhibitor of Excitatory amino acid transporter 4;Inhibitor of Excitatory amino acid transporter 5
DL-TBOA - ≥98%(HPLC), high purity , CAS No.205309-81-5, Inhibitor of Excitatory amino acid transporter 1;Inhibitor of Excitatory amino acid transporter 2;Inhibitor of Excitatory amino acid transporter 3;Inhibitor of Excitatory amino acid transporter 4;Inhibitor of Excitatory amino acid transporter 5
Selective non-transportable inhibitor of EAATs
Basic Description Synonyms DL-TBOA|205309-81-5|(3s)-3-(Benzyloxy)-L-Aspartic Acid|DL-Threo-Beta-Benzyloxyaspartate|(2S,3S)-2-amino-3-phenylmethoxybutanedioic acid|DL-threo-beta-Benzyloxyaspartic acid|208706-75-6|CHEMBL79140|DL-TBOA ammonium|C11H13NO5|L-threo-benzyloxy aspartate|TB1 Specifications & Purity Moligand™, ≥98%(HPLC) Biochemical and Physiological Mechanisms A competitive, non-transportable blocker of excitatory amino acid transporters (IC50values are 70, 6, and 6μM for EAAT1, EAAT2 and EAAT3 respectively). Also inhibits EAAT4 and EAAT5 (Kivalues are 4.4 and 3.2μM respectively). Displays high selectivity for Storage Temp Store at -20°C,Desiccated Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of Excitatory amino acid transporter 1;Inhibitor of Excitatory amino acid transporter 2;Inhibitor of Excitatory amino acid transporter 3;Inhibitor of Excitatory amino acid transporter 4;Inhibitor of Excitatory amino acid transporter 5
Names and Identifiers IUPAC Name (2S,3S)-2-amino-3-phenylmethoxybutanedioic acid INCHI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1 InChi Key BYOBCYXURWDEDS-IUCAKERBSA-N Canonical SMILES C1=CC=C(C=C1)COC(C(C(=O)O)N)C(=O)O Isomeric SMILES C1=CC=C(C=C1)CO[C@@H]([C@@H](C(=O)O)N)C(=O)O PubChem CID 5311218 Molecular Weight 239.23
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 23.92, Max Conc. mM: 100; Solvent:water, Max Conc. mg/mL: 1.2, Max Conc. mM: 5 with gentle warming
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