DMA trihydrochloride is a fluorescent compound (λ ex =340 nm, λ em =478 nm).
In Vitro
The newly synthesized bisbenzimidazole derivatives DMA (6c) is evaluated for their cytotoxicity against human tumor cell lines, which are cervix carcinoma cell line (HeLa), breast carcinoma cell line (MCF7) and brain glioma cell line (U87) in comparison to Hoechst. In case of MCF7, the IC 50 is observed at 5.3 μM for DMA. The IC 50 determined in the case of HeLa is 3.4 μM for DMA. MCE has not independently confirmed the accuracy of these methods. They are for reference only.