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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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D129922-5mg | 5mg | In stock | $29.90 | |
D129922-25mg | 25mg | In stock | $79.90 | |
D129922-100mg | 100mg | In stock | $239.90 | |
D129922-250mg | 250mg | In stock | $479.90 | |
D129922-1g | 1g | In stock | $999.90 |
Vascular disrupting agent. VEGFR inhibitor.
Synonyms | Vadimezan|DMXAA|117570-53-3|5,6-Mexaa|2-(5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid|5,6-Dimethylxantheonone-4-acetic Acid|AS-1404|DMXAA (Vadimezan)|ASA-404|5,6-Dimethylxanthenone-4-acetic acid|ASA404|NSC-640488|Dimethyloxoxanthene acetic acid|Vadimeza |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | DMXAA is an apoptosis inducer, and an anti-vascular. DMXAA is an inhibitor of NQO1, Flk-1 and Flt-1.Vascular disrupting agent. VEGFR inhibitor. Potent type I interferon inducer. Increases vascular permeability and vascular endothelial apoptosis. Inhibits |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | 5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a flavone acetic acid derivative. It acts as a vascular disrupting agent (VDA), which damages tumor vasculature and stimulates an anti-tumor immune response. It stimulates hemorrhagic necrosis. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Pubchem Sid | 488187781 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488187781 |
IUPAC Name | 2-(5,6-dimethyl-9-oxoxanthen-4-yl)acetic acid |
INCHI | InChI=1S/C17H14O4/c1-9-6-7-13-15(20)12-5-3-4-11(8-14(18)19)17(12)21-16(13)10(9)2/h3-7H,8H2,1-2H3,(H,18,19) |
InChi Key | XGOYIMQSIKSOBS-UHFFFAOYSA-N |
Canonical SMILES | CC1=C(C2=C(C=C1)C(=O)C3=CC=CC(=C3O2)CC(=O)O)C |
Isomeric SMILES | CC1=C(C2=C(C=C1)C(=O)C3=CC=CC(=C3O2)CC(=O)O)C |
WGK Germany | 3 |
RTECS | ZD5536200 |
PubChem CID | 123964 |
Molecular Weight | 282.29 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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F2414256 | Certificate of Analysis | May 27, 2024 | D129922 |
F2414255 | Certificate of Analysis | May 27, 2024 | D129922 |
F2414251 | Certificate of Analysis | May 27, 2024 | D129922 |
F2414246 | Certificate of Analysis | May 27, 2024 | D129922 |
G2201285 | Certificate of Analysis | Apr 07, 2024 | D129922 |
I2124095 | Certificate of Analysis | Jul 17, 2023 | D129922 |
G2326412 | Certificate of Analysis | Jul 06, 2023 | D129922 |
G2326399 | Certificate of Analysis | Jul 06, 2023 | D129922 |
G2326397 | Certificate of Analysis | Jul 06, 2023 | D129922 |
G2326395 | Certificate of Analysis | Jul 06, 2023 | D129922 |
K1913123 | Certificate of Analysis | Jun 08, 2023 | D129922 |
E2325461 | Certificate of Analysis | May 08, 2023 | D129922 |
E2325459 | Certificate of Analysis | May 08, 2023 | D129922 |
E2325458 | Certificate of Analysis | May 08, 2023 | D129922 |
E2325457 | Certificate of Analysis | May 08, 2023 | D129922 |
E2325456 | Certificate of Analysis | May 08, 2023 | D129922 |
E2325454 | Certificate of Analysis | May 08, 2023 | D129922 |
E2325453 | Certificate of Analysis | May 08, 2023 | D129922 |
E2325452 | Certificate of Analysis | May 08, 2023 | D129922 |
E2325450 | Certificate of Analysis | May 08, 2023 | D129922 |
D2115334 | Certificate of Analysis | Jan 17, 2023 | D129922 |
G2201210 | Certificate of Analysis | Jun 05, 2022 | D129922 |
G2201277 | Certificate of Analysis | Jun 05, 2022 | D129922 |
G2201286 | Certificate of Analysis | Jun 05, 2022 | D129922 |
G2201366 | Certificate of Analysis | Jun 05, 2022 | D129922 |
Solubility | Soluble in DMSO (>10 mg/ml), DMF (~14 mg/ml), 1:1 solution of DMF: PBS (pH=7.2) (~0.5 mg/ml), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). |
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Sensitivity | heat sensitive |
Melt Point(°C) | 264 °C |
Pictogram(s) | GHS09, GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed H400:Very toxic to aquatic life |
Precautionary Statements | P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
WGK Germany | 3 |
RTECS | ZD5536200 |
Starting at $185.90