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DNA-PK Inhibitor III - ≥95%, high purity , CAS No.404009-40-1, Inhibitor of protein kinase; DNA-activated; catalytic subunit
a potent, selective, & an ATP-competitive inhibitor of DNA-PK & PI 3-Kinase catalytic subunit p110β
Basic Description Synonyms 404009-40-1|DNA-PK Inhibitor III|1-(2-HYDROXY-4-MORPHOLINOPHENYL)ETHANONE|IC86621|1-(2-Hydroxy-4-morpholin-4-yl-phenyl)ethanone|IC 86621|CHEMBL1317546|IC-86621; IC86621|1-(2-hydroxy-4-morpholinophenyl)ethan-1-one|Ethanone, 1-[2-hydroxy-4-(4-morpholinyl)ph Specifications & Purity Moligand™, ≥95% Storage Temp Store at 2-8°C,Protected from light Shipped In Wet ice Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of protein kinase; DNA-activated; catalytic subunit Product Description DNA-PK Inhibitor III is a cell-permeable aryl-morpholino compound that is potent, selective, and an ATP-competitive inhibitor of DNA-PK (IC|50|= 120 nM) and PI 3-Kinase catalytic subunit p110β (IC|50|= 135 nM). Inhibits DNA-PK-mediated cellular DNA DSB (double strand break) repair (EC|50|= 68 μM) and enhances DSB-induced antitumor activity|in vitro|, while exhibiting no cytotoxic effects (up to 50 μM) in the absence of DSBs. Also inhibits PI 3K p110α, p110γ, and p110δ only at much higher concentrations (IC50= 1.4 μM, 880 nM, and 1.0 μM, respectively) and exhibits no effect against a panel of several other kinases, including, Cdk2, Src, PKA, PKC, Chk1, CK1, ATM, and FKBP12, even at concentrations as high as 100 μM.
Product Properties pKa pKₐ: 10.47 (Predicted), pKₐ: 1.95 (Predicted)
Names and Identifiers IUPAC Name 1-(2-hydroxy-4-morpholin-4-ylphenyl)ethanone INCHI InChI=1S/C12H15NO3/c1-9(14)11-3-2-10(8-12(11)15)13-4-6-16-7-5-13/h2-3,8,15H,4-7H2,1H3 InChi Key YHKSBKQXCWHTQL-UHFFFAOYSA-N Canonical SMILES CC(=O)C1=C(C=C(C=C1)N2CCOCC2)O Isomeric SMILES CC(=O)C1=C(C=C(C=C1)N2CCOCC2)O WGK Germany 3 PubChem CID 9859309 Molecular Weight 221.26
Chemical and Physical Properties Solubility Soluble in DMSO (5 mg/ml). Sensitivity Light sensitive Refractive Index n20D1.57 (Predicted) Boil Point(°C) 425.49° C at 760 mmHg (Predicted) Melt Point(°C) 98-100.3° C
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3
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