DNA-PK Inhibitor V - 98%, high purity , CAS No.404009-46-7, Inhibitor of protein kinase; DNA-activated; catalytic subunit

Item Number

D337627

• Synonyms: DNA-PK Inhibitor V|404009-46-7|AMA-37|AMA37|1-(2-Hydroxy-4-morpholin-4-yl-phenyl)-phenyl-methanone|AM-A37|AMA 37|CHEMBL478980|AMA-37; AMA37; DNA-PK Inhibitor V|(2-Hydroxy-4-morpholin-4-yl-phenyl)-phenyl-methanone|2-benzoyl-5-(morpholin-4-yl)phenol|(2-hydr
• Specifications & Purity: Moligand™, ≥98%
• Storage Temp: Protected from light,Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of protein kinase; DNA-activated; catalytic subunit

Product Description

DNA-PK Inhibitor V is a morpholino-benzophenone compound. Potent, selective and ATP-competitive inhibitor of DNA-PK (IC|50|= 270 nM). Inhibits PI 3-K catalytic subunit p110-isozymes at higher concentrations (IC|50|= 32 μM, 3.7 μM, 22 μM and ~ 100μM for α, β, δ and γ, respectively) and weakly inhibits a panel of several other kinases, including, ATM, ATR, CK2, GRK2, mTOR, PI 3KC2α, PI 3KC2β, PI 3KC2γ and PI 4Kβ, even at concentrations as high as 50μM.