β1-Adrenoceptor receptor agonist.β 1 and β 2 adrenoceptor agonist. Displays some activity at α 1 adrenoceptors. Synthetic catecholamine. Shows positive inotropic effect.
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Dobutamine Hcl(Dobutrex) is a sympathomimetic drug used in the treatment of heart failure and cardiogenic shock. Its primary mechanism is direct stimulation of β1 receptors of the sympathetic nervous system.
1.Pollak AJ et al.. (2018) A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure.. Elife, 7 [PMID:30520731]
2.Tyurin-Kuzmin PA et al.. (2016) Activation of ß-adrenergic receptors is required for elevated a1A-adrenoreceptors expression and signaling in mesenchymal stromal cells.. Sci Rep, 6 (32835). [PMID:27596381]
3.Novoseletskaya E et al.. (2020) Mesenchymal Stromal Cell-Produced Components of Extracellular Matrix Potentiate Multipotent Stem Cell Response to Differentiation Stimuli.. Front Cell Dev Biol, 8 (555378). [PMID:33072743]
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I1820240